:: Volume 23, Issue 3 (Bimonthly 2019) ::
Feyz 2019, 23(3): 280-285 Back to browse issues page
Assessment of the diagnostic value of urine protein content in 8- and 16-hour samples with 24-hour urine protein sample in hospitalized women with pre-eclampsia in 2016
Parisa Pirooznia , Maryam Ahmadi * , Sajjad Daneshyar
Department of Obstetrics and Gynaecology, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, I. R. Iran. , ahmadi_1011@yahoo.com
Abstract:   (2323 Views)
Background: High blood pressure disorders are common in pregnancy. The combination of high blood pressure and proteinuria in pregnancy, or pre-eclampsia, dramatically increases the risk of death and perinatal complications. Nevertheless, 24-hour urine protein sample is still a gold standard. This study aimed to determine and compare the diagnostic value of 8- and 16-hour urine protein samples with that of 24-hour urine protein sample.
Material and Methods: This cross-sectional study was performed on 92 pregnant women with hypertension and gestational age greater than 20 weeks who were evaluated for proteinuria and rejection of pre-eclampsia and 92 pregnant women with gestational age greater than 20 weeks and normal blood pressure. All patients had been admitted to the women's ward of Imam Reza Hospital in Kermanshah. Three consecutive 8-hour samples were collected from each patient, and the protein was sampled at 8, 16 and 24 hours.
Results: Correlation coefficient between 16- and 24-hour urine protein samples was 0.832 (the highest correlation coefficient), which showed a strong correlation between 16- and 24-hour urine protein samples. The correlation coefficients of urine protein between the first and third 8-hours were 0.621 and 0.528, respectively, which showed a moderate correlation with 24-hour urine protein. Urine protein for the first 16 hours had a high efficacy rate of 96.3% and negative predictive value of 97.5% in diagnosis of non-patient cases. However, due to the sensitivity of 82.6%, there was no definitive value in detecting abnormal cases.
Conclusion: The negative result of the first 16-hour urine protein can have a significant effect on rejection of pre-eclampsia in hospitalized or outpatient patients.
Keywords: Proteinuria, Pre-eclampsia, Pregnant women, Complications of pregnancy
Full-Text [PDF 179 kb]   (2877 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2018/11/3 | Revised: 2019/07/31 | Accepted: 2019/04/24 | Published: 2019/07/31
1. Cunningham FG, Leveno KJ, Bloom S, Hauth J, Rouse D, Spong C. Pregnancy hypertension. Williams Obstetrics 2010; 23: 706.
2. Adelberg AM, Miller J, Doerzbacher M, Lambers DS. Correlation of quantitative protein measurements in 8-, 12-, and 24-hour urinesamples for the diagnosis of preeclampsia. Am J Obstetrics Gynecol 2001; 185(4): 804-7.
3. Gifford R. Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol 2000; 183: S1-S15.
4. Higby K, Suiter CR, Phelps JY, Siler-Khodr T, Langer O. Normal values of urinary albumin and total protein excretion during pregnancy. Am J Obstet Gynecol 1994; 171(4): 984-9.
5. Chan P, Brown M, Simpson JM, Davis G. Proteinuria in pre‐eclampsia: how much matters? Int J Obstet Gynaecol 2005; 112(3): 280-5.
6. Airoldi J, Weinstein L. Clinical significance of proteinuria in pregnancy. Obstet Gynecol Surv 2007; 62(2): 117-24.
7. Amirabi A, Golmohammadlu S, Yekta Z, Naji S, Danaii S. Correlation of 4- Hour Urinary Proteins With 24-Hours Proteinuria In Hospitalized Pregnant Patients With Hypertensive Disorder. J Urmia Univ Med Sci 2010; 21(1): 10-6. [in Persian]
8. James D. Hypertension in Pregnancy (In): Steer PJ, WeinerCP, Gonik B. High Risk Pregnancy Management Options 1999; 2: 639-65.
9. Singhal SR, Ghalaut V, Lata S, Madaan H, Kadian V, Sachdeva A. Correlation of 2 hour, 4 hour, 8 hour and 12 hour urine protein with 24 hour urinary protein in preeclampsia. J Offamily Reproductive Health 2014; 8(3): 131.
10. Wongkitisophon K, Phupong V, Yamasmit W, Pansin P, Tannirandorn Y, Charoenvidhya D. Correlation of 4-and 24-hour urine protein in women with initially diagnosed hypertensive disorders in pregnancy. J Medical Association Thailand= Chotmaihet Thangphaet 2003; 86(6): 529-34.
11. Schubert FP, Abernathy MP. Alternate evaluations of proteinuria in the gravid hypertensive patient. J Reproductive Med 2006; 51(9): 709-14.
12. KielerH, Zettergren T, Svensson H, Dickman PW, Larsson A. Assessing urinary albumin excretion in pre-eclamptic women: which sample to use? Int J Obstetrics Gynaecol 2003; 110(1): 12-7.

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