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Effect of zinc chloride on the passive avoidance memory of female rats ovariectomized in the pre-pubertal stage
Pooran Ghahramani * , Hooman Eshagh Harooni , Seyed Raza Fatemi Tabatabaei , Ahmad Ali Moazedi
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran. , p.ghahramani1393@gmail.com
Abstract:   (158 Views)
Background: Many studies have shown that Zinc has an important effect on learning, memory and cognition. On the other hand, ovariectomy in adult female rats reduces memory and learning, also. According to contradictory reports effects of Zinc chloride on memory and learning, in this study the effect of zinc chloride was investigated on passive avoidance memory of ovariectomized female rats in the pre-pubertal stage.
Material and Methods: In this experiment, fifty female rats were ovariectomized at postnatal day 21-22 and were divided into six groups, control, sham (saline), ovariectomized (saline) and the ovariectomized groups receiving Zinc chloride 5, 10 and 20 mg/kg at puberty. Then on postnatal day 77, passive avoidance memory was examined by the shuttle box. Different doses of zinc chloride were administered 30 min before training and the test took place 24 hours later.
Results: Ovariectomy decreased the stopping time in the dark room compared with the sham group, non-significantly. Groups receiving zinc chloride 5 mg/kg showed a significantly increase in stopping time in the dark room compared to the ovariectomized group receiving saline (P<0.01).
Conclusion: The findings of this study showed that pre-pubertal ovariectomy has no effect on passive avoidance memory and injection of zinc chloride can be reduced memory and learning.
Keywords: Pre-pubertal ovariectomy, Zinc chloride, Shuttle box, Passive avoidance
     
Type of Study: Research | Subject: medicine, paraclinic
Received: 2018/05/15 | Accepted: 2019/05/18
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