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:: Volume 22, Issue 4 (Bimonthly 2018) ::
Feyz 2018, 22(4): 387-393 Back to browse issues page
Comparison of serum apelin levels and maximal oxygen consumption in active and inactive obese men
Salar Abasi , Mahmoud Nikseresht *
Department of Exercise Physiology, Ilam Branch, Islamic Azad University, Ilam, I. R. Iran. , nikserasht@gmail.com
Abstract:   (178 Views)
Backgrounds: Apelin is an adipokine that may play a significant role in regulating energy metabolism. Obesity and physical activity are factors that affect the concentration of apelin, but it is not known which one is more prominent. Thus, the aim of this study was to compare the serum levels of apelin-13 and the maximal oxygen consumption (VO2max) in men who are inactive normal-weight, active and inactive obese.
Materials and Methods: Forty-five healthy men (age range, 34-46 years) were assigned to one of the following groups. 1) active-obese: body mass index (BMI)=28-33.9 kg/m2, 3-5 score in the physical activity rate questionnaire (PAR-Q) and n=16; 2) inactive-obese: BMI = 28-33.9 kg/m2, 1 in PAR-Q and n=18; 3) inactive normal-weight: BMI=18.5-24.9 kg/m2, 1 in PAR-Q and n=11. Blood samples were collected from the subjects in a fasting state; then, the serum level of apelin-13 was measured by the ELISA method. The VO2max was estimated by the non-exercise method and based on the PAR-Q.
Results: One-way ANOVA showed that there was no significant difference in the serum levels of apelin-13 between the groups (P=0.73). It was found that VO2max was significantly lower in the inactive-obese group compared to the other groups (P≤0.001); however, no significant difference was noted between the active-obese and inactive normal-weight groups (P=0.14).
Conclusion: Findings of this study show that the moderate physical activity and type 1 obesity could not be effective in apelin-13 concentration. In addition, it can be suggested that the obesity and physical activity indices have the same reciprocal effects in maximal oxygen consumption.
Keywords: Apelin-13 peptide, Body mass index, VO2max, Physical fitness
Full-Text [PDF 252 kb]   (37 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/01/24 | Accepted: 2018/07/14 | Published: 2018/10/6
References
1. Everett BM, Bansal S, Rifai N, Buring JE, Ridker PM. Interleukin-18 and the risk of future cardiovascular disease among initially healthy women. Atherosclerosis 2009; 202(1): 282-8.
2. Freitas Lima LC, Braga VA, do Socorro de França Silva M, Cruz JC, Sousa Santos SH, de Oliveira Monteiro MM, et al. Adipokines, diabetes and atherosclerosis: an inflammatory association. Front Physiol 2015; 6: 304.
3. Kadoglou NP, Vrabas IS, Kapelouzou A, Angelopoulou N. The association of physical activity with novel adipokines in patients with type 2 diabetes. Eur J Intern Med 2012; 23(2): 137-42.
4. Reinehr T, Woelfle J, Roth CL. Lack of association between apelin, insulin resistance, cardiovascular risk factors, and obesity in children: a longitudinal analysis. Metabolism 2011; 60(9): 1349-54.
5. Gualillo O, González-Juanatey JR, Lago F. The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectives. Trends Cardiovasc Med 2007; 17(8): 275-83.
6. Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 2000; 74(1): 34-41.
7. Castan-Laurell I, Vítkova M, Daviaud D, Dray C, Kováčiková M, Kovacova Z , et al. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur J Endocrinol 2008; 158(6): 905-10.
8. Kadoglou NP, Tsanikidis H, Kapelouzou A, Vrabas I, Vitta I, Karayannacos PE, et al. Effects of rosiglitazone and metformin treatment on apelin, visfatin, and ghrelin levels in patients with type 2 diabetes mellitus. Metabolism 2010; 59(3): 373-9.
9. Szczepanska-Sadowska E, Cudnoch-Jedrz‌ej‌e‌wska A, Ufnal M, Zera T. Brain and cardio‌vascular diseases: common neurogenic background of cardiovascular, metabolic and inflammatory diseases. J Physiol Pharmacol 2010; 61(5): 509-21.
10. Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a sec‌retory organ. Nat Rev Endocrinol 2012; 8(8): 457-65.
11. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta 2010; 411(11-12): 785-93.
12. Nikseresht M, Rajabi H, Nikseresht A. The effects of nonlinear resistance and aerobic interval training on serum levels of apelin and insulin resistance in middle-aged obese men. Tehran Univ Med J 2015; 73(5): 375-83.
13. Heyward VH, Gibson A. Advanced fitness assessment and exercise prescription. 7th ed. Human kinetics; 2014.
14. Jackson AS, Blair SN, Mahar MT, Wier LT, Ross RM, Stuteville JE. Prediction of functional aerobic capacity without exercise testing. Med Sci Sports Exerc 1990; 22(6): 863-70.
15. Matthews CE, Heil DP, Freedson PS, Pastides H. Classification of cardiorespiratory fitness without exercise testing. Med Sci Sports Exerc 1999; 31(3): 486-93.
16. Nikseresht M, Hafezi Ahmadi MR, Hedayati M. Detraining-induced alterations in adipokines and cardiometabolic risk factors after nonlinear periodized resistance and aerobic interval training in obese men. Appl Physiol Nutr Metab 2016; 41(10): 1018-25.
17. Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 2005; 146(4): 1764-71.
18. Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, Quilliot D, et al. TNFα up-regulates apelin expression in human and mouse adipose tissue. FASEB J 2006; 20(9): 1528-30.
19. Heinonen MV, Laaksonen DE, Karhu T, Karhunen L, Laitinen T, Kainulainen S, et al. Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndrome. Nutr Metab Cardiovasc Dis 2009; 19(9): 626-33.
20. Heinonen MV, Purhonen AK, Miettinen P, Pääkkönen M, Pirinen E, Alhava E, et al. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul Pept 2005; 130(1): 7-13.
21. Soriguer F, Garrido-Sanchez L, Garcia-Serrano S, Garcia-Almeida JM, Garcia-Arnes J, Tinahones FJ, et al. Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus. Obes Surg 2009; 19(11): 1574-80.
22. Radovanović S, Kocić S, Gajović G, Radević S, Milosavljević M, Nićiforović J. The impact of body weight on aerobic capacity. Med Glas (Zenica) 2014; 11(1): 204-9.
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Abasi S, Nikseresht M. Comparison of serum apelin levels and maximal oxygen consumption in active and inactive obese men. Feyz. 2018; 22 (4) :387-393
URL: http://feyz.kaums.ac.ir/article-1-3516-en.html


Volume 22, Issue 4 (Bimonthly 2018) Back to browse issues page
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