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:: Volume 22, Issue 2 (Bimonthly 2018) ::
Feyz 2018, 22(2): 169-176 Back to browse issues page
Study of the association between Dicer (rs3742330 A>G) and Drosha (rs10719 C>T) gene polymorphisms and the risk of recurrent pregnancy loss
Negin Mohseni , Saeid Ghorbian *
Assistant Professor Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, I. R. Iran. , ghorbian20@yahoo.com
Abstract:   (306 Views)
Background: Drosha and Dicer are important molecules that play critical regulatory roles in the biogenesis of micro-RNA. Genetic polymorphism in the Drosha and Dicer can cause defect on the embryo implantation and lead to the recurrent abortion. The aim of this study was to evaluate an association between Drosha and Dicer gene polymorphisms and the risk of recurrent pregnancy loss (RPL).
Materials and Methods: This case-control study was performed on 100 women with RPL (with unknown reasons) and 100 women with a successful pregnancy (one alive child) and no abortion history referred to Imam Khomeini Hospital in Ardebil city during 2015-2017. The frequencies of these polymorphisms were evaluated using the PCR-RFLP method.
Results: Results showed no statistically significant difference in the genotype frequency of the Dicer gene polymorphism between the case and control groups (P>0.05). On the other hand, a statistically significant difference was found in the genotype frequency of the Drosha gene polymorphism between the groups (P<0.05).
Conclusion: It seems that the Drosha gene polymorphism can be a predisposing genetic factor for RPL, whereas the Dicer gene polymorphism cannot be considered as a risk factor for predisposing RPL in the studied population.
Keywords: Recurrent abortion, Polymorphism, Drosha, Dicer
Full-Text [PDF 289 kb]   (35 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2017/10/8 | Accepted: 2018/05/1 | Published: 2018/05/1
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Mohseni N, Ghorbian S. Study of the association between Dicer (rs3742330 A>G) and Drosha (rs10719 C>T) gene polymorphisms and the risk of recurrent pregnancy loss. Feyz. 2018; 22 (2) :169-176
URL: http://feyz.kaums.ac.ir/article-1-3444-en.html


Volume 22, Issue 2 (Bimonthly 2018) Back to browse issues page
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