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:: Volume 22, Issue 1 (4-2018) ::
Feyz 2018, 22(1): 39-47 Back to browse issues page
The effect of Punica granatum L. along with aerobic training on resistin, serum adiponectin and insulin resistance in women with type 2 diabetes
Ahmad Abdi * , Orod Aohajer iravani
Assistant Professor Department of sport Physiologhy, Ayatollah Amoli Branch, Islamic Azad University, Amol, I. R. Iran.
Abstract:   (683 Views)
Background: Factors secreted from adipocytes, such as resistin and adiponectin can affect peripheral insulin resistance and type 2 diabetes. Physical activity and pomegranate, which has both anti-inflammatory and antioxidant properties can affect resistin and adiponectin. The aim of this study was to examine the effect of Punica granatum L. along with aerobic training on serum resistin, adiponectin and insulin resistance in women with type 2 diabetes.
Materials and Methods: In this study, 33 diabetic women with type 2 diabetes were selected from Babol city and were randomly divided into four groups (control, P. granatum L., training and P. granatum L.+ training). The training groups participated in an aerobic training for six weeks, three sessions a week (60% to 75% of the reserved heart rate and for 25 to 45 min). The control groups of P. granatum L. and P. granatum L. + training were fed 150 mL of P. granatum L. for six weeks (at about 18 p.m). Two days before and after the protocol, blood samples were taken.
Results: The results showed that there was no significant difference in the serum resistin levels among the three experimental groups. Also, the results showed a significant difference between adiponectin levels and insulin resistance in four groups.
Conclusions: It seems that aerobic training and P. granatum L. and combination of both can have anti-inflammatory and antioxidant effects on reduction of adiponectin and insulin resistance in women with type 2 diabetes.
Keywords: Aerobic exercise, Punica granatum L., Resistin, Adiponectin, Type 2 diabetes
Full-Text [PDF 286 kb]   (9 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/06/19 | Accepted: 2017/11/6 | Published: 2018/01/10
1. Irvine C, Taylor NF. Progressive resistance exercise improves glycaemic control in people with type 2 diabetes mellitus: a systematic review. Aust J Physiotherapy 2009; 55(4): 237-46.
2. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999; 104(6): 787.
3. Blaschke F, Takata Y, Caglayan E, Law RE, Hsueh WA. Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. Arterioscler Thromb Vasc Biol 2006; 26(1): 28-40.
4. Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 2005; 111(7): 932-9.
5. McTernan PG, Fisher FM, Valsamakis G, Chetty R, Harte A, McTernan CL, et al. Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. J Clin Endocrinol Metab 2003; 88(12): 6098-106.
6. Cho YM, Youn BS, Chung SS, Kim KW, Lee H, Yu KY, et al. Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans. Diabetologia 2004; 47(3): 559-65.
7. Tang NP, Wang LS, Yang L, Zhou B, Gu HJ, Sun QM, et al. A polymorphism in the resistin gene promoter and the risk of coronary artery disease in a Chinese population. Clin Endocrinol 2008; 68(1): 82-7.
8. Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, et al. Regulation of fasted blood glucose by resistin. Science 2004; 303(5661): 1195-8.
9. Więcek A, Adamczak M, Chudek J. Adiponectin—an adipokine with unique metabolic properties. Nephrol Dialysis Transplantation 2007; 22(4): 981-8.
10. Gilardini L, McTernan PG, Girola A, da Silva NF, Alberti L, Kumar S, et al. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis 2006; 189(2): 401-7.
11. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271(18): 10697-703.
12. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, et al. Hypo‌adipo‌nectinemia in obesity and type 2 diabetes: close asso‌ciation with insulin resistance and hyper‌insulinemia. J Clin Endocrinol Metab 2001; 86(5): 1930-5.
13. Izadi M, Zarifian A, Aghami A, Khorshidi D, Samarikhalaj H. Investigation of the relationship between adiponectin and beta-cell function in patients with type II diabetes. Sci J Kurdistan Univ Med Sci 2011; 60(16): 1-8. [in Persian]
14. Blomhoff R. [Antioxidants and oxidative stress]. Tidsskrift for den Norske lægeforening: tidsskrift for praktisk medicin, ny Række 2004; 124(12): 1643-5.
15. Medjakovic S, Jungbauer A. Pomegranate: a fruit that ameliorates metabolic syndrome. Food Funct 2013; 4(1): 19-39.
16. McFarlin BK, Strohacker KA, Kueht ML. Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice. Br J Nutr 2008; 102(1): 54-9.
17. Henriksen EJ. Invited review: effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 2002; 93(2): 788-96.
18. Perseghin G, Price TB, Petersen KF, Roden M, Cline GW, Gerow K, et al. Increased glucose transport–phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. New England J Med 1996; 335(18): 1357-62.
19. Jamurtas AZ, Theocharis V, Koukoulis G, Stakias N, Fatouros I, Kouretas D, et al. The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males. Eur J Appl Physiol 2006; 97(1): 122-6.
20. Shavandi N, Saremi A, Ghorbani A, Parastesh M. Relationship between adiponectin and insulin resistance in type II diabetic men after aerobic training. Arak Med Univ J 2011; 14(2): 43-50.
21. Abdi A, Abbasi dalloee A, Salehpour M, fatemi SR, iman talab fomani S. The effect of aerobic training with pomegranate juice plasma apolipoproteins in women with type 2 diabetes. J Exercise Physiol Physical Activity 2016; 18: 1425-34. [in Persian]
22. Panichayupakaranant P, Itsuriya A, Sirikatitham A. Preparation method and stability of ellagic acid-rich pomegranate fruit peel extract. Pharm Biol 2010; 48(2): 201-5.
23. Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian‐Kopaei M. Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti‐Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects. Phytotherapy Res 2014; 28(2): 193-9.
24. Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C, Jarema C, et al. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res 2003; 11(9): 1048-54.
25. Giannopoulou I, Fernhall B, Carhart R, Wein‌stock RS, Baynard T, Figueroa A, et al. Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes. Metabolism 2005; 54(7): 866-75.
26. Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 2007; 56(7): 1005-9.
27. Moon B, Kwan JJ-M, Duddy N, Sweeney G, Begum N. Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation. Am J Physiol Endocrinol Metab 2003; 285(1): E106-15.
28. Heilbronn L, Rood J, Janderova L, Albu J, Kelley D, Ravussin E, et al. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocrinol Metab 2004; 89(4): 1844-8.
29. Makino-Wakagi Y, Yoshimura Y, Uzawa Y, Zaima N, Moriyama T, Kawamura Y. Ellagic acid in pomegranate suppresses resistin secretion by a novel regulatory mechanism involving the degradation of intracellular resistin protein in adipocytes. Biochem Biophys Res Commun 2012; 417(2): 880-5.
30. Yang Y, Shin JY, Oh JM, Jung CH, Hwang Y, Kim S, et al. Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper. Proceedings National Academy Sci 2010; 107(51): 22145-50.
31. Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM. Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE 2 production in human chondrocytes in vitro. J Inflammation 2008; 5(1): 9.
32. Durstine JL, Grandjean PW, Cox CA, Thompson PD. Lipids, lipoproteins, and exercise. J Cardiopulmonary Rehabil Prev 2002; 22(6): 385-98.
33. Oberbach A, Tönjes A, Klöting N, Fasshauer M, Kratzsch J, Busse MW, et al. Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol 2006; 154(4): 577-85.
34. Zeng Q, Isobe K, Fu L, Ohkoshi N, Ohmori H, Takekoshi K, et al. Effects of exercise on adiponectin and adiponectin receptor levels in rats. Life Sci 2007; 80(5): 454-9.
35. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004; 350(23): 2362-74.
36. Wagner H, Fischer H, Degerblad M, Alvarsson M, Gustafsson T. Improvement of insulin sensitivity in response to exercise training in type 2 diabetes mellitus is associated with vascular endothelial growth factor A expression. Diab Vasc Dis Res 2016: 13(5): 361-6.
37. Bonner JS, Lantier L, Hasenour CM, James FD, Bracy DP, Wasserman DH. Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance. Diabetes 2013; 62(2): 572-80.
38. Bektas N, Ozturk Y. Effect of phenolic acids on functions of rat aorta, vas deferens and on metabolic changes in streptozotocin-induced diabetes. Indian J Pharmacol 2012; 44(2): 184.
39. Rozenberg O, Howell A, Aviram M. Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it. Atherosclerosis 2006; 188(1): 68-76.
40. Banihani S, Swedan S, Alguraan Z. Pomegranate and type 2 diabetes. Nutr Res 2013; 33(5): 341-8.
41. Marques-Vidal P, Schmid R, Bochud M, Bastardot F, Von Känel R, Paccaud F, et al. Adipocytokines, hepatic and inflammatory biomarkers and incidence of type 2 diabetes. the CoLaus study. PLoS One 2012; 7(12): e51768.
42. Mojtaba E, Mahdi K, Mehdi KJ, Amir S. Serum interleukin-1 beta plays an important role in insulin secretion in type II diabetic. J Biosci 2011; 1(3): 93-9.
43. Davoodi B, Zilaei Bouri S, Ahangarpor A, Zilaei Bouri M. Effects of Two Different Physical Exercises on Plasma Levels of Adiponectin and Resistin in Obese and Overweight Young Girls. Arak Med Univ J 2014; 17(4): 27-37.[in persian]
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Abdi A, Aohajer iravani O. The effect of Punica granatum L. along with aerobic training on resistin, serum adiponectin and insulin resistance in women with type 2 diabetes. Feyz. 2018; 22 (1) :39-47
URL: http://feyz.kaums.ac.ir/article-1-3369-en.html

Volume 22, Issue 1 (4-2018) Back to browse issues page
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