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:: Volume 21, Number 2 (Bimonthly 2017) ::
Feyz 2017, 21(2): 118-125 Back to browse issues page
Effect of crocin on inhibitory avoidance memory, balance and explorative behaviours following cisplatin administration in rat
Zohreh Ghotbeddin , Seyyed Reza Fatemi-Tabatabaei, Mohamad Reza Tabandeh, Mohsen Mirzabeigi, Nima Badripour, Rezvan Amiri
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran. , z.ghotbeddin@scu.ac.ir
Abstract:   (294 Views)

Background: A lot of studies indicate that cancer chemotherapy results in memory and motor impairment immediately following therapy. On the other side, crocin as the chemical constituent isolated from the Saffron is effective on memory and motor impairement. In this study, the effect of crocin on memory and motor impairment induced by cisplatin injection was studied in adult male rats. 

Materials and Methods: In this study, male Wistar rats (n=50) were divided into 5 groups: Control, Sham, Cisplatin (2 mg/kg/week for 21 days), Crocin (30 mg/kg for 21 days) and   Cisplatin+Crocin. Sham group was administrated with Saline. Then, inhibitory avoidance memory, balance and exploratory behaviors were assessed by shuttle box, rotarod and open field apparatus, respectively.

Results: Crocin improved memory impairment induced by cisplatin (P<0.01). Cisplatin also impaired balance in rotarod test. Rearing frequency and total distance traveled in open field test were significantly decreased (P<0.001 and P<0.05, respectively) compared to Control group.

Conclusion: We conclude that crocin injection following the use of anticancer drugs (e.g. cisplatin) might have a protective effect against the cisplatin-induced impairement in cognitive function, balance and explorative behavior.

Keywords: Crocin, Cisplatin, Passive avoidance memory, Motor activity, Rat
Full-Text [PDF 274 kb]   (111 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/05/24 | Accepted: 2017/05/24 | Published: 2017/05/24
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Ghotbeddin Z, Fatemi-Tabatabaei S R, Tabandeh M R, Mirzabeigi M, Badripour N, Amiri R. Effect of crocin on inhibitory avoidance memory, balance and explorative behaviours following cisplatin administration in rat. Feyz. 2017; 21 (2) :118-125
URL: http://feyz.kaums.ac.ir/article-1-3345-en.html
Volume 21, Number 2 (Bimonthly 2017) Back to browse issues page
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