[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 21, Number 2 (Bimonthly 2017) ::
Feyz 2017, 21(2): 118-125 Back to browse issues page
Effect of crocin on inhibitory avoidance memory, balance and explorative behaviours following cisplatin administration in rat
Zohreh Ghotbeddin , Seyyed Reza Fatemi-Tabatabaei, Mohamad Reza Tabandeh, Mohsen Mirzabeigi, Nima Badripour, Rezvan Amiri
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran. , z.ghotbeddin@scu.ac.ir
Abstract:   (501 Views)

Background: A lot of studies indicate that cancer chemotherapy results in memory and motor impairment immediately following therapy. On the other side, crocin as the chemical constituent isolated from the Saffron is effective on memory and motor impairement. In this study, the effect of crocin on memory and motor impairment induced by cisplatin injection was studied in adult male rats. 

Materials and Methods: In this study, male Wistar rats (n=50) were divided into 5 groups: Control, Sham, Cisplatin (2 mg/kg/week for 21 days), Crocin (30 mg/kg for 21 days) and   Cisplatin+Crocin. Sham group was administrated with Saline. Then, inhibitory avoidance memory, balance and exploratory behaviors were assessed by shuttle box, rotarod and open field apparatus, respectively.

Results: Crocin improved memory impairment induced by cisplatin (P<0.01). Cisplatin also impaired balance in rotarod test. Rearing frequency and total distance traveled in open field test were significantly decreased (P<0.001 and P<0.05, respectively) compared to Control group.

Conclusion: We conclude that crocin injection following the use of anticancer drugs (e.g. cisplatin) might have a protective effect against the cisplatin-induced impairement in cognitive function, balance and explorative behavior.

Keywords: Crocin, Cisplatin, Passive avoidance memory, Motor activity, Rat
Full-Text [PDF 274 kb]   (190 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/05/24 | Accepted: 2017/05/24 | Published: 2017/05/24
References
1. [1] Pitsikas N. The effect of Crocus sativus L. and its constituents on memory: basic studies and clinical applications. Evid Based Complement Alternat Med 2015; 2015: 926284.
2. [2] Pitsikas N, Zisopoulou S, Tarantilis PA, Kanakis CD, Polissiou MG, Sakellaridis N. Effects of the active constituents of Crocus sativus L., crocins on recognition and spatial rats' memory. Behav Brain Res 2007; 183(2): 141-6.
3. Ghadrdoost B, Vafaei AA, Rashidy-Pour A, Hajisoltani R, Bandegi AR, Motamedi F, et al. Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. Eur J Pharmacol 2011; 667(1-3): 222-9.
4. Schmidt M, Betti G, Hensel A. Saffron in phytotherapy: pharmacology and clinical uses. Wien Med Wochenschr 2007; 157(13-14): 315-9.
5. Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Mohajeri SA. Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res 2012; 26(3): 381-6.
6. Hajiaghaee R, Akhondzadeh S. Herbal medicine in the treatment of Alzheimer’s disease. J Med Plants 2012; 1(41): 1-7.
7. Khalili M, Hamzeh F. Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats. Iran Biomed J 2010; 14(1-2): 59.
8. Georgiadou G, Grivas V, Tarantilis PA, Pitsikas N. Crocins, the active constituents of Crocus Sativus L., counteracted ketamine–induced behavioural deficits in rats. Psychopharmacology 2014; 231(4): 717-26.
9. Rao SV, Yenisetti SC, Rajini PS. Evidence of neuroprotective effects of saffron and crocin in a Drosophila model of parkinsonism. Neurotoxicology 2016; 52: 230-42.
10. Papandreou MA, Tsachaki M, Efthimiopoulos S, Cordopatis P, Lamari FN, Margarity M. Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection. Behav Brain Res 2011; 219(2): 197-204.
11. Ghadami MR, Pourmotabbed A. The effect of Crocin on scopolamine induced spatial learning and memory deficits in rats. Physiol Pharmacol 2009; 12(4): 287-95.
12. Anderson-Hanley C, Sherman ML, Riggs R, Agocha VB, Compas BE. Neuropsychological effects of treatments for adults with cancer: a meta-analysis and review of the literature. J Int Neuropsychol Soc 2003; 9(07): 967-82.
13. Mustafa S, Walker A, Bennett G, Wigmore PM. 5‐Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. Eur J Neurosci 2008; 28(2): 323-30.
14. Konat GW, Kraszpulski M, James I, Zhang HT, Abraham J. Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats. Metab Brain Dis 2008; 23(3): 325-33.
15. Roda E, Avella D, Pisu MB, Bernocchi G. Monoamine receptors and immature cerebellum cytoarchitecture after cisplatin injury. J Chem Neuroanat 2007; 33(1): 42-52.
16. Ali BH, Al Moundhri MS. Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food Chem Toxicol 2006; 44(8): 1173-83.
17. Gibbs RB, Gabor R, Cox T, Johnson DA. Effects of raloxifene and estradiol on hippocampal acetylcholine release and spatial learning in the rat. Psychoneuroendocrinology 2004; 29(6): 741-8.
18. Pisu M, Roda E, Avella D, Bernocchi G. Developmental plasticity of rat cerebellar cortex after cisplatin injury: inhibitory synapses and differentiating Purkinje neurons. Neurosci 2004; 129(3): 655-64.
19. Pisu MB, Roda E, Guioli S, Avella D, Bottone MG, Bernocchi G. Proliferation and migration of granule cells in the developing rat cerebellum: cisplatin effects. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology. Anat Rec 2005; 287(2): 1226-35.
20. Reiriz AB, Reolon GK, Preissler T, Rosado JO, Henriques JA, Roesler R, et al. Cancer chemotherapy and cognitive function in rodent models: memory impairment induced by cyclophosphamide in mice. Clin Cancer Res 2006; 12(16): 5000-1.
21. Kebieche M, Lakroun Z, Lahouel M, Bouayed J, Meraihi Z, Soulimani R. Evaluation of epirubicin-induced acute oxidative stress toxicity in rat liver cells and mitochondria, and the prevention of toxicity through quercetin administration. Exp Toxicol Pathol 2009; 61(2): 161-7.
22. Bandegi AR, Rashidy-Pour A, Vafaei AA, Ghadrdoost B. Protective effects of Crocus Sativus L. extract and crocin against chronic-stress induced oxidative damage of brain, liver and kidneys in rats. Pharm Bull 2014; 4 (Suppl 2): 493-9.
23. Oz M, Atalik KE, Yerlikaya FH, Demir EA. Curcumin alleviates cisplatin-induced learning and memory impairments. Neurobiol Learn Mem 2015; 123: 43-9.
24. Shabani M, Hosseinmardi N, Haghani M, Shaibani V, Janahmadi M. Maternal exposure to the CB1 cannabinoid agonist WIN 55212–2 produces robust changes in motor function and intrinsic electrophysiological properties of cerebellar Purkinje neurons in rat offspring. Neurosci 2011; 172: 139-52.
25. Shabani M, Larizadeh MH, Parsania S, Asadi Shekaari M, Shahrokhi N. Profound destructive effects of adolescent exposure to vincristine accompanied with some sex differences in motor and memory performance. Canadian J Physiol Pharmacol 2012; 90(4): 379-86.
26. Ghotbeddin Z, Moazedi AA, Parham GA. Effect of combined administration of Zinc chloride and Aluminum chloride on memory and motor activity of young rats. Physiol Pharmacol 2007; 11(2): 146-52.
27. Callizot N, Andriambeloson E, Glass J, Revel M, Ferro P, Cirillo R, et al. Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity. Cancer Chemother Pharmacol 2008; 62(6): 995-1007.
28. Carew TJ. Behavioral neurobiology: the cellular organization of natural behavior. Yale J Biol Med 2000; 75(1): 63.
29. Goldman JG, Stebbins GT, Bernard B, Stoub TR, Goetz CG, deToledo‐Morrell L. Entorhinal cortex atrophy differentiates Parkinson's disease patients with and without dementia. Mov Disord 2012; 27(6): 727-34.
30. Sanders LH, Greenamyre JT. Oxidative damage to macromolecules in human Parkinson disease and the rotenone model. Free Radic Biol Med 2013; 62: 111-20.
31. Ettehadi H, Mojabi SN, Ranjbaran M, Shams J, Sahraei H, Hedayati M, et al. Aqueous Extract of Saffron (Crocus sativus) Increases Brain Dopamine and Glutamate Concentrations in Rats. J Behav Brain Sci 2013; 3(3): 315-19.
32. Purushothuman S, Nandasena C, Peoples CL, El Massri N, Johnstone DM, Mitrofanis J, et al. Saffron pre-treatment offers neuroprotection to Nigral and retinal dopaminergic cells of MPTP-Treated mice. J Parkinson's Dis 2013; 3(1): 77-83.
33. Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M. CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol 2006; 5(7): 1.
34. Thomson D, McFarland K, Kelly B, Wyld D, Walpole E, Troy L, et al. Cisplatin-based therapy: a neurological and neuropsychological review. Psychooncology 2000; 9(1): 29-39.
35. Rzeski W, Pruskil S, Macke A, Felderhoff‐Mueser U, Reiher AK, Hoerster F, et al. Anticancer agents are potent neurotoxins in vitro and in vivo. Ann Neurol 2004; 56(3): 351-60.
36. Seigers R, Schagen SB, Coppens CM, van der Most PJ, van Dam FS, Koolhaas JM, et al. Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats. Behav Brain Res 2009; 201(2): 279-84.
37. Satoh M, Kashihara N, Fujimoto S, Horike H, Tokura T, Namikoshi T, et al. A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo. J Pharm ExpTher 2003; 305(3): 1183-90.
38. Tamaddonfard E, Farshid AA, Asri-Rezaee S, Javadi S, Khosravi V, Rahman B, et al. Crocin improved learning and memory impairments in streptozotocin-induced diabetic rats. Iran J basic Med Sci 2013; 16(1): 91-100.
39. Abe K, Sugiura M, Shoyama Y, Saito H. Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons. Brain Res 1998; 787(1): 132-8.
40. Naghizadeh B, Mansouri MT, Ghorbanzadeh B, Farbood Y, Sarkaki A. Protective effects of oral crocin against intracerebroventricular streptozotocin-induced spatial memory deficit and oxidative stress in rats. Phytomedicine 2013; 20(6): 537-542.
41. Asadi F, Jamshidi AH, Khodagholi F, Yans A, Azimi L, Faizi M, et al. Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers. Pharmacol Biochem Behav 2015; 139 (Pt A): 47-58.
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghotbeddin Z, Fatemi-Tabatabaei S R, Tabandeh M R, Mirzabeigi M, Badripour N, Amiri R. Effect of crocin on inhibitory avoidance memory, balance and explorative behaviours following cisplatin administration in rat. Feyz. 2017; 21 (2) :118-125
URL: http://feyz.kaums.ac.ir/article-1-3345-en.html
Volume 21, Number 2 (Bimonthly 2017) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.048 seconds with 844 queries by yektaweb 3506