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:: Volume 21, Issue 6 (Bimonthly 2017) ::
Feyz 2017, 21(6): 506-516 Back to browse issues page
Improvement of spatial memory of male parkinsonian rats after treatment with adipose stem cells and rosemary leaf extract
Mahdieh Ramezanihossienabadi, Maryam Haji-Ghasem-Kashani *, Kataneh Abrari
Faculty of Biology and Institute of Biological Sciences, Damghan University, Damghan, I. R. Iran. , kashani@du.ac.ir
Abstract:   (2376 Views)
Background: Due to the neuroprotective effect of rosemary extract, this study aimed at examining the effect of co-treatment of adipose stem cells transplantation and the extract on memory disability of parkinsonian rats.
Materials and Methods: In this experimental study, male parkinsonian rats were prepared by bilateral injection of 6-OHDA. The sham group was injected normal saline into the substantia nigra. The extract+medium group was gavaged with the extract 14 days before until 8 weeks after the injury, and the medium was intravenously injected. The extract+cell group was orally gavaged with the extract and the cells were injected. Morris water maze training was conducted one week before and after the lesion and also a retrieval test was performed 4 and 8 weeks after the lesion.
Results: There was no significant difference in distance moved and escape latency at training days, before the injury, between the groups. However, a week after the injury, learning ability in lesioned animals was significantly decreased as compared to the sham group (P<0.05). Results of retention tests in four and eight weeks were similar. Duration of escape latency and time spent in target quadrant of lesioned rats were significantly increased and decreased respectively as compared to the sham (P<0.05). The extract+medium and extract+cell groups showed significant decrease and increase in escape latency and time spent in target quadrant as compared to the lesioned group (P<0.05), respectively.
Conclusion: The cell therapy accompanied with orally administration of the rosemary extract can improve memory deficit in Parkinson’s disease. 
Keywords: Stem cell, Rosemary extract, Parkinson, Spatial memory, Morris water maze
Full-Text [PDF 515 kb]   (621 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2017/03/24 | Accepted: 2017/11/6 | Published: 2018/01/6
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Ramezanihossienabadi M, Haji-Ghasem-Kashani M, Abrari K. Improvement of spatial memory of male parkinsonian rats after treatment with adipose stem cells and rosemary leaf extract. Feyz. 2017; 21 (6) :506-516
URL: http://feyz.kaums.ac.ir/article-1-3307-en.html

Volume 21, Issue 6 (Bimonthly 2017) Back to browse issues page
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