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:: Volume 21, Issue 6 (Bimonthly 2017) ::
Feyz 2017, 21(6): 517-524 Back to browse issues page
The effect of hydro-alcoholic extract of Salvia officinalis L. on the electrolytes and serum proteins in adult diabetic male rat
Maryam Mirchenari *, Farnaz Tavakoli
Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, I. R. Iran. , maryammir900@gmail.com
Abstract:   (292 Views)
Background: Diabetes is the result of functional impairment of insulin secretion. The aim of this study was to examine the effect of the Salvia officinalis (SO) extract on serum levels of albumin, total protein and serum sodium and potassium electrolytes.
Materials and Methods: In this experimental study, 50 adult male Wistar rats were divided into 5 groups of 10. The control group received food and water, the diabetic group received 60 mg/kg streptozotocin, the SO-treated control group received 400 mg/kg of SO daily, and the SO-treated diabetic groups received 200 and 400 mg/kg of SO daily. Injections were performed intraperitoneally. After 21 days, the blood sample was taken from the heart to measure the factors.
Results: The serum concentration of potassium in the diabetic group showed a significant increase compared to the control group and showed a significant decrease in the treated diabetic group compared to the diabetic group. The serum concentration of sodium in the diabetic group was significantly lower than the control group. Also, the serum concentrations of albumin and total proteins in the diabetic group significantly decreased compared to the control group and these concentrations significantly increased in the treated diabetic groups compared to the diabetic group. Moreover, the serum levels of albumin and total proteins in the treated control group significantly increased compared to the control group (P≤0.05).
Conclusion: The antioxidant compounds of the SO extract can increase the serum concentrations of total protein, albumin, potassium and sodium and have been proven effective in reducing complications of diabetes.
Keywords: Diabetes, Salvia officinalis L., Albumin, Total protein, Serum electrolytes
Full-Text [PDF 273 kb]   (65 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/01/9 | Accepted: 2017/11/12 | Published: 2018/01/7
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Mirchenari M, Tavakoli F. The effect of hydro-alcoholic extract of Salvia officinalis L. on the electrolytes and serum proteins in adult diabetic male rat. Feyz. 2017; 21 (6) :517-524
URL: http://feyz.kaums.ac.ir/article-1-3239-en.html

Volume 21, Issue 6 (Bimonthly 2017) Back to browse issues page
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