:: Volume 20, Issue 6 (Bimonthly 2017) ::
Feyz 2017, 20(6): 518-524 Back to browse issues page
Association between serum lactate and postoperative outcomes following coronary artery bypass graft surgery
Fatemeh Hasanshiri, Mohammad Sadegh Pourabbasi *, Seyyed Gholam Abbas Mousavi, Mojdeh Fatahi, Amir Abbas Kianfar, Hamid Reza Seyedi, Fakhrosadat Mirhoseini, Mehrdad Mahdian
Department of Heart, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I. R. Iran. , drmpourabbasi@yahoo.com
Abstract:   (3745 Views)

Background: Increased serum lactate during cardio-pulmonary bypass is associated with high mortality and cardiac complications up to 10-20 percent. The aim of this study was to evaluate the effect of serum lactate increase on postoperative outcomes after coronary artery bypass graft (CABG) Surgery.

Materials and Methods: This descriptive-analytical study was performed on cases (no=116) undergoing CABG at Beheshti hospital in Kashan between 2013-2014. Demographic data, variables related to surgery, serum lactate level and the time of tracheal extubation, length of stay in intensive care unit (ICU) and hospital post-surgery left ventricular ejection fraction were collected. These data was compared in two groups: Normal serum lactate (< 2 m molliter) and Hyperlactatemia (> 2 m molliter) group.

Results: The postoperative hyperlactatemia was observed in 62.1 % of patients. There were no significant differences between two groups in time of tracheal extubation, length of stay in ICU and hospital. There was a relationship between the mean postoperative serum lactate and blood sugar, bicarbonate, pH, length of cardiopulmonary bypass and the aortic cross clamping time. There was a significant relationship between the serum lactate increment and the left ventricular ejection fraction decrement.

Conclusion: Hyperlactatemia is probably associated with such important factors as high blood sugar, longer duration of aortic cross clamp and cardio-pulmonary bypass time. So controlling such factors can reduce the rate of hyperlactatemia and help postoperative recovery.

Keywords: Coronary artery bypasses graft, Serum lactate, Cardiopulmonary bypass, Postoperative outcomes
Full-Text [PDF 224 kb]   (1061 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/01/2 | Accepted: 2017/01/2 | Published: 2017/01/2
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