:: Volume 21, Number 3 (Bimonthly 2017) ::
Feyz 2017, 21(3): 218-223 Back to browse issues page
Hyoscine-N-butylbromide effect on the acceleration of labor and postpartum hemorrhage in primigravida women
Zahra Pahlavani-Sheikhi , Maryam Razavi
Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, I. R. Iran. , pahlavani-86@yahoo.com
Abstract:   (115 Views)
Background: Hyoscine-N-butylbromide is a potent anticholinergic agent with its prominent spasmolytic action on uterus and cervix smooth-muscle in the first stage of labor. This study aimed to evaluate the effect of Hyoscine-N-butylbromide on the acceleration of labor and rupture of the cervix in primigravida women.
Materials and Methods: This double-blind randomized clinical trial was conducted at Ali Ibn-e- Abi Talib hospital of Zahedan on primigravida women (n=105). With the initiation of active phase of labor either Hyoscine-N-butylbromide (40 mg, i.v.) or Saline (2 ml) was administered. Duration of the first, second and third stages of labor and the rate of cervix rupture were compared in two groups.
Results: A significant difference was seen for the duration of the first stage of labor (181±59.1 versus 208.2±48.5 min) in two groups (P=0.012).There was no significant difference for the duration of the second and third stages of labor. Although rate of cervix rupture was lower in the Hyoscine group, no significant difference was observed between the two groups.
Conclusion: Hyoscine-N-butylbromide is effective in accelerating the first stage of labor and has no effect on the rate of cervix rupture and postpartum hemorrhage.
Keywords: Hyoscine-N-butylbromide, Labor acceleration, Stages of labor, Postpartum hemorrhage
Full-Text [PDF 172 kb]   (54 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/11/18 | Accepted: 2017/05/11 | Published: 2017/07/30
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