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:: Volume 20, Issue 5 (Bimonthly 2016) ::
Feyz 2016, 20(5): 454-460 Back to browse issues page
The presence of Helicobacter pylori in gallbladder mucosa of patients with chronic cholecystitis
Farzad Kheirmand *, Fahimeh Valadi, Kamran Dolatshahi
School of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, I. R. Iran. , farzadkheirmand@yahoo.com
Abstract:   (2365 Views)

Background: Helicobacter pylori (H. pylori) has infected over half of the world’s population. Among the long-term outcomes of H.pylori infection is gastric malignancies, particularly gastric cancer and gastric mucosa-associated tissue (MALT) lymphoma. In recent years, the attention has been drawn to the possible association of H. pylori infections not only with gastric and duodenal disorders but also with several gastrointestinal diseases (e.g. liver and biliary diseases). H. pylori have recently found to be associated with some diseases of the biliary tree. Earlier reports on the detection of H. pylori in the gallbladder mucosa of patients with biliary disease have shown contradictory results which requires further studies. The aim of this cross-sectional study was to determine the presence of H. pylori in gallbladder mucosa of patients with a diagnosis of chronic cholecystitis using histological study of surgical gallbladder specimens.

Materials and Methods: In the present study, gallbladder samples (total no=70) from patients with chronic cholecystitis were collected at Shariati hospital (Isfahan, Iran) from February to April 2015. Giemsa staining was used to detect H. pylori in gallbladder mucosa.

Results: Using Giemsa staining in 18 (25.7%) out of 70 patients gallbladder mucosa were positive for H. pylori. There was an association between the presence of H. pylori in the gallbladder mucosa and chronic cholecystitis. (P<0.001)

Conclusion: H. pylori can be detected in gallbladder mucosa of patients with chronic cholecystitis. Further studies are needed to support these findings.

Keywords: Helicobacter pylori, Gallbladder tissue, Chronic cholecystitis
Full-Text [PDF 351 kb]   (894 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/11/13 | Accepted: 2016/11/13 | Published: 2016/11/13
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Kheirmand F, Valadi F, Dolatshahi K. The presence of Helicobacter pylori in gallbladder mucosa of patients with chronic cholecystitis. Feyz. 2016; 20 (5) :454-460
URL: http://feyz.kaums.ac.ir/article-1-3180-en.html

Volume 20, Issue 5 (Bimonthly 2016) Back to browse issues page
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