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Effect of six weeks voluntary exercise on hepatic Superoxide Dismutase and Apoptosis inducing factor before doxorubicin administration in aging model rats
Saied Kamal Sadat-Hoseini , Valiollah Dabidi Roshan *
Professor , vdabidiroshan@yahoo.com
Abstract:   (84 Views)

Background: In the last decade, cancer incidence increases exponentially with advancing age. While, older cancer patients haven't ability to participate in treatment programs, due to the special physical condition and side effects of anti-tumor drugs. Hence, the aim of this study was to investigate the effect of six weeks voluntary exercise on DOX-induced hepatotoxicity, in aging model rats.

Materials and Methods: Thirty-two Wistar male rats randomly assigned to exercise and control groups with 4 sub group. All subjects received a daily injection of D-galactose for nine weeks (100 mg/kg/day, i.p.) The training protocol included six weeks voluntary wheel running exercise. DOX was administrated intraperitoneally for 15 days (1 mg⋅mL−1⋅kg−1⋅day−1). SOD and AIF levels assay were performed after liver tissue homogenization by enzyme-linked immunosorbent assay (ELISA) method.

Results: Administration cumulative dose of DOX caused insignificant decrease in SOD and AIF levels (P=0.913, P=1.000; respectively). Six weeks voluntary wheel running exercise led to insignificant decrease in SOD and insignificant increase in AIF in comparison to similar control group(P=0.545, P=1.000; respectively).

Conclusion: The result has shown that, six weeks voluntary wheel running exercise had no significant effect on DOX-induced hepatotoxicity in aging model rats.

Keywords: Voluntary exercise, Doxorubicin, hepatic toxicity, Oxidative stress, apoptosis
     
Type of Study: Research | Subject: General
Received: 2016/10/31 | Accepted: 2018/06/17
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Sadat-Hoseini S K, Dabidi Roshan V. Effect of six weeks voluntary exercise on hepatic Superoxide Dismutase and Apoptosis inducing factor before doxorubicin administration in aging model rats. Feyz. 2018; 22 (3)
URL: http://feyz.kaums.ac.ir/article-1-3153-en.html


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