[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 4 (Bimonthly 2016) ::
Feyz 2016, 20(4): 315-322 Back to browse issues page
Effect of aqueous extract of Lavandula angustifolia on LTP induction in a rat model of Alzheimer disease
Masoud Soheili , Mostafa Rezaei Tavirani , Mahmoud Salami *
Professor Physiology Research Center, Kashan University of Medical Sciences, Kashan, I. R. Iran. , salami-m@kaums.ac.ir
Abstract:   (1339 Views)

Bachground: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with deficits in synaptic plasticity. Long-term potentiation (LTP) is an experimental method for synaptic plasticity assessment. This study evaluated the effect of aqueous extract of lavender (Lavandula angustifolia) on induction of LTP in the CA1 region of hippocampus.

Materials and Methods: The animals were divided in 3 groups: Control animals receiving distilled water (CO), Alzheimer group receiving distilled water (AD); Alzheimer group receiving lavender extract (A+EXT). The electrophysiological recordings were carried out in 3 groups of rats. The baseline or tetanized extracellular postsynaptic field potentials (fEPSPs) were recorded in response to the stimulation of Schaffer collaterals.

Results: The data showed no effect of the extract on the baseline responses in all groups. While the recorded fEPSPs in the CO showed a substantial LTP, no potentiation was seen in the AD group. Administration of the aqueous extract of lavender effectively restored the LTP in A+EXT group.

Conclusion: In line with our previous reports, this study showed the positive effect of lavender extract on the induction of LTP in a rat model of Alzheimer disease.

Keywords: Alzheimer’s disease, Hippocampus, Long-term potentiation, Lavandula angustifolia, Rat
Full-Text [PDF 263 kb]   (394 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/10/10 | Accepted: 2016/10/10 | Published: 2016/10/10
References
1. Zhou J, Liu B. Alzheimer's disease and prion protein. Intractable Rare Dis Res 2013; 2(2): 35-44.
2. Danysz W, Parsons CG. Alzheimer's disease, beta-amyloid, glutamate, NMDA receptors and memantine--searching for the connections. Br J Pharmacol 2012; 167(2): 324-52.
3. Singh S, Kushwah AS, Singh R, Farswan M, Kaur R. Current therapeutic strategy in Alzheimer's disease. Eur Rev Med Pharmacol Sci 2012; 16(12): 1651-64.
4. Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T. Synthetic ceramide analogues increase amyloid-beta 42 production by modulating gamma-secretase activity. Biochem Biophys Res Commun 2015; 457(2): 194-9.
5. He YX, Wu MN, Zhang H, Qi JS. Amyloid beta-protein suppressed nicotinic acetylcholine receptor-mediated currents in acutely isolated rat hippocampal CA1 pyramidal neurons. Synapse 2013; 67(1): 11-20.
6. Maatuk N, Samson AO. Modeling the binding mechanism of Alzheimer's Aβ1-42 to nicotinic acetylcholine receptors based on similarity with snake α-neurotoxins. Neurotoxicology 2013; 34: 236-42.
7. Hoppe JB, Frozza RL, Horn AP, Comiran RA, Bernardi A, Campos MM, et al. Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation. J Pineal Res 2010; 48(3): 230-8.
8. Piermartiri TC, Figueiredo CP, Rial D, Duarte FS, Bezerra SC, Mancini G, et al. Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-beta (1-40) administration in mice: evidence for dissociation between cognitive deficits and neuronal damage. Exp Neurol 2010; 226(2): 274-84.
9. Gulbrandsen TL, Sparks FT, Sutherland RJ. Interfering with post-learning hippocampal activity does not affect long-term consolidation of a context fear memory outside the hippocampus. Behav Brain Res 2013; 240: 103-9.
10. Pan YW, Storm DR, Xia Z. The Maintenance of Established Remote Contextual Fear Memory Requires ERK5 MAP Kinase and Ongoing Adult Neurogenesis in the Hippocampus. PLoS One 2012; 7(11): e50455.
11. Jo J, Whitcomb DJ, Olsen KM, Kerrigan TL, Lo SC, Bru-Mercier G, et al. Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta. Nat Neurosci 2011; 14(5): 545-7.
12. Origlia N, Capsoni S, Cattaneo A, Fang F, Arancio O, Yan SD, et al. Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE. J Alzheimers Dis. 2009; 17(1): 59-68.
13. Huang MY, Liao MH, Wang YK, Huang YS, Wen HC. Effect of lavender essential oil on LPS-stimulated inflammation. Am J Chin Med 2012; 40(4): 845-59.
14. Kim Y, Kim M, Kim H, Kim K. Effect of lavender oil on motor function and dopamine receptor expression in the olfactory bulb of mice. J Ethnopharmacol 2009; 125(1): 31-5.
15. Kashani MS, Tavirani MR, Talaei SA, Salami M. Aqueous extract of lavender (Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer's disease. Neurosci Bull 2011; 27(2): 99-106.
16. Soheili M, Tavirani MR, Salami M. Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia. Neurosci Med 2012; 3(4):6.
17. Soheili M, Salami M, Haghir A, Zali H, Rezaei Tavirani M. Aqueous Extract of Lavandula Angustifolia Alter Protein Expression in Alzheimer Rats. J Rep Pharm Sci 2014; 3(1): 9.
18. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates - The New Coronal Set: Elsevier Science; 2004.
19. Philippi N, Noblet V, Botzung A, Despres O, Renard F, Sfikas G, et al. MRI-Based Volumetry Correlates of Autobiographical Memory in Alzheimer's Disease. PLoS One 2012; 7(10): e46200.
20. Vargas LM, Leal N, Estrada LD, Gonzalez A, Serrano F, Araya K, et al. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-beta oligomers. PLoS One 2014; 9(3): e92309.
21. Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, et al. Alzheimer's disease brain-derived amyloid-beta-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J Neurosci 2011; 31(20): 725.
22. Ni R, Marutle A, Nordberg A. Modulation of alpha7 Nicotinic Acetylcholine Receptor and Fibrillar Amyloid-beta Interactions in Alzheimer's Disease Brain. J Alzheimers Dis 2013; 33(3): 841-51.
23. Tomas M, Garcia N, Santafe MM, Lanuza M, Tomas J. Protein kinase C involvement in the acetylcholine release reduction induced by amyloid-beta(25-35) aggregates on neuromuscular synapses. J Alzheimers Dis 2009; 18(4): 877-84.
24. Hritcu L, Cioanca O, Hancianu M. Effects of lavender oil inhalation on improving scopolamine-induced spatial memory impairment in laboratory rats. Phytomedicine 2012; 19(6): 529-34.
25. Matos M, Augusto E, Machado NJ, dos Santos-Rodrigues A, Cunha RA, Agostinho P. Astrocytic adenosine A2A receptors control the amyloid-beta peptide-induced decrease of glutamate uptake. J Alzheimers Dis 2012; 31(3): 555-67.
26. Alberdi E, Sanchez-Gomez MV, Cavaliere F, Perez-Samartin A, Zugaza JL, Trullas R, et al. Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors. Cell Calcium 2010; 47(3): 264-72.
27. Lin PW, Chan WC, Ng BF, Lam LC. Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial. Int J Geriatr Psychiatry 2007; 22(5): 405-10.
28. Perez Nievas BG, Hammerschmidt T, Kummer MP, Terwel D, Leza JC, Heneka MT. Restraint stress increases neuroinflammation independently of amyloid beta levels in amyloid precursor protein/PS1 transgenic mice. J Neurochem 2011; 116(1): 43-52.
29. He FQ, Qiu BY, Zhang XH, Li TK, Xie Q, Cui DJ, et al. Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-kappaB activation in a rat model of Alzheimer's disease induced by amyloid-beta(1-42). Brain Res 2011; 1384: 89-96.
30. Fakhfouri G, Ahmadiani A, Rahimian R, Grolla AA, Moradi F, Haeri A. WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-gamma pathway. Neuropharmacology 2012; 63(4): 653-66.
31. Chen HQ, Jin ZY, Wang XJ, Xu XM, Deng L, Zhao JW. Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. Neurosci Lett 2008; 448(2): 175-9.
32. Hajhashemi V, Ghannadi A, Sharif B. Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J Ethnopharmacol 2003; 89(1): 67-71.
33. Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2003; 75(3): 651-9.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Soheili M, Rezaei Tavirani M, Salami M. Effect of aqueous extract of Lavandula angustifolia on LTP induction in a rat model of Alzheimer disease . Feyz. 2016; 20 (4) :315-322
URL: http://feyz.kaums.ac.ir/article-1-3127-en.html


Volume 20, Issue 4 (Bimonthly 2016) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3752