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:: Volume 20, Issue 4 (Bimonthly 2016) ::
Feyz 2016, 20(4): 315-322 Back to browse issues page
Effect of aqueous extract of Lavandula angustifolia on LTP induction in a rat model of Alzheimer disease
Masoud Soheili , Mostafa Rezaei Tavirani , Mahmoud Salami *
Professor Physiology Research Center, Kashan University of Medical Sciences, Kashan, I. R. Iran. , salami-m@kaums.ac.ir
Abstract:   (1339 Views)

Bachground: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with deficits in synaptic plasticity. Long-term potentiation (LTP) is an experimental method for synaptic plasticity assessment. This study evaluated the effect of aqueous extract of lavender (Lavandula angustifolia) on induction of LTP in the CA1 region of hippocampus.

Materials and Methods: The animals were divided in 3 groups: Control animals receiving distilled water (CO), Alzheimer group receiving distilled water (AD); Alzheimer group receiving lavender extract (A+EXT). The electrophysiological recordings were carried out in 3 groups of rats. The baseline or tetanized extracellular postsynaptic field potentials (fEPSPs) were recorded in response to the stimulation of Schaffer collaterals.

Results: The data showed no effect of the extract on the baseline responses in all groups. While the recorded fEPSPs in the CO showed a substantial LTP, no potentiation was seen in the AD group. Administration of the aqueous extract of lavender effectively restored the LTP in A+EXT group.

Conclusion: In line with our previous reports, this study showed the positive effect of lavender extract on the induction of LTP in a rat model of Alzheimer disease.

Keywords: Alzheimer’s disease, Hippocampus, Long-term potentiation, Lavandula angustifolia, Rat
Full-Text [PDF 263 kb]   (394 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/10/10 | Accepted: 2016/10/10 | Published: 2016/10/10
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Soheili M, Rezaei Tavirani M, Salami M. Effect of aqueous extract of Lavandula angustifolia on LTP induction in a rat model of Alzheimer disease . Feyz. 2016; 20 (4) :315-322
URL: http://feyz.kaums.ac.ir/article-1-3127-en.html

Volume 20, Issue 4 (Bimonthly 2016) Back to browse issues page
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