:: Volume 20, Issue 4 (Bimonthly 2016) ::
Feyz 2016, 20(4): 306-314 Back to browse issues page
The protective effect of fenugreek (Trigonella foenum-graecum) seed powder on acetaminophen-induced hepatotoxicity in male rats
Aghileh Mohammadzadeh, Ali Gol *, Abdoreza Javadi
Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, I. R. Iran. , agol@mail.uk.ac.ir
Abstract:   (2143 Views)

Background: Acetaminophen overdose is the most prevalent cause of drug-induced liver injury. Many traditional treatments are recommended as the complementary and alternative options for treating various diseases. In this study the effect of fenugreek seed powder on the acetaminophen-induced hepatotoxicity is investigated.

Materials and Methods: In this experimental study, male Wistar rats (no=24, weight 250-280 g) were divided into four groups: Control (C), Fenugreek seed powder (T); Acetaminophen (A); and Acetaminophen+Fenugreek seed powder (A+T). After 24 h of fasting, A and A+T groups received Acetaminophen 1000 mg/kg by gavage, and the other two groups received  Saline. After six hours, C and A groups received Saline, whereas T and A+T groups received Fenugreek seed powder 1000 mg/kg via gavage. Twelve hours after the second gavage, the rats were sacrificed and the liver tissue was fixed with formalin and assessed. Results were analyzed using ANOVA and Tukey post-test.

Results: Serum ALT and AST levels were significantly increased in group A compared to C (P<0.001 and 0.01, respectively). In addition, Acetaminophen resulted in liver tissue injury (necrosis, apoptosis, bleeding, and hyperemia). Treatment with fenugreek reversed the changes toward normal.

Conclusion: Fenugreek can have protective effects on hepatic injury induced by Acetaminophen.

Keywords: Fenugreek Powder, Acetaminophen, Hepatotoxicity, Rat
Full-Text [PDF 886 kb]   (713 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/10/10 | Accepted: 2016/10/10 | Published: 2016/10/10
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