[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 3 (Bimonthly 2016) ::
Feyz 2016, 20(3): 282-296 Back to browse issues page
Reviewing the physiological effects of aerobic and resistance training on insulin resistance and some biomarkers in non-alcoholic fatty liver disease
Azam Moosavi-Sohroforouzani * , Mohsen Ganbarzadeh
PhD Student in Exercise Physiology, School of Physical education and Sport Sciences, Shahid Chamran University, Ahvaz, I. R. Iran. , azamsadat_moosavi@yahoo.com
Abstract:   (2791 Views)

Background: During recent decades exercise has emerged as a key adjuvant tool in the control of many diseases, including non-alcoholic fatty liver diseases (NAFLD). In addition, studies have demonstrated that different training protocols were effective in reducing the prevalence of the disorder and improving some liver metabolic functions. The purpose of this review was to summarize and analyze articles about the effects of aerobic and resistance training on insulin resistance and some biomarkers in NAFLD.

Materials and Methods: The PubMed, Medline, Irandoc, SID, Google Scholar and Magiran databases were searched for the physiological effects of two types of training) aerobic and resistance( on NAFLD. Totally, among the 300 articles reviewed, 107 ones were selected for later consideration.

Results: Although through different mechanisms, the non-alcoholic fatty liver patients can benefit from both types of aerobic and resistance training.

Conclusion: Regardless of the type of training, on engaging in regular physical activity the non-alcoholic fatty liver patients may effectively control and improve the emerging inflammatory processes, obesity and insulin resistance.

Keywords: Nonalcoholic fatty liver disease, Physical activity, Insulin resistance, Obesity
Full-Text [PDF 345 kb]   (3154 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/08/13 | Accepted: 2016/08/13 | Published: 2016/08/13
1. Jakovljevic DG, Hallsworth K, Zalewski P, Thoma C, Klawe JJ, Day CP, et al. Resistance exercise improves autonomic regulation at rest and haemodynamic response to exercise in non-alcoholic fatty liver disease. Clin Sci (Lond) 2013; 125(3): 143-9.
2. Farzanegi P, Pour Amin Z, Habibian M. Changes of Liver Trans-Aminases after a Period of Selected Aerobic Training in Postmenopausal Women. Med Laboratory J 2014; 8(1): 22-8. [in Persian]
3. Nabizadeh Haghighi A, Shabani R. Comparison of drug therapy with exersice program on body composition and cardio-pulmonary fitness in patients with nonalcoholic fatty liver disease. Iran J Rehabil Res Nurs 2015; 1(4): 70-82. [in Persian]
4. Bacchi E, Negri C, Targher G, Faccioli N, Lanza M, Zoppini G, et al. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial). Hepatology 2013; 58(4): 1287-95.
5. Gutierrez-Grobe Y, Gavilanes-Espinar JG, Mendez-Sanchez N. Physical activity and nonalcoholic fatty liver disease. Ann Hepatol 2009; 8(3): 273-4.
6. Masarone M, Federico A, Abenavoli L, Loguercio C, Persico M. Non alcoholic fatty liver: epidemiology and natural history. Rev Recent Clin Trials 2014; 9(3): 126-33.
7. Oliveira CP, de Lima Sanches P, de Abreu-Silva EO, Marcadenti A. Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease. J Diabetes Res 2016; 2016: 4597246.
8. Petta S, Muratore C, Craxì A. Non-alcoholic fatty liver disease pathogenesis: the present and the future. Dig Liver Dis 2009; 41(9): 615-25.
9. Yoshimura E, Kumahara H, Tobina T, Matsuda T, Ayabe M, Kiyonaga A, et al. Lifestyle intervention involving calorie restriction with or without aerobic exercise training improves liver fat in adults with visceral adiposity. J Obes 2014; 2014: 197216.
10. Keating SE, George J, Johnson NA. The benefits of exercise for patients with non-alcoholic fatty liver disease. Expert Rev Gastroenterol Hepatol 2015; 9(10): 1247-50.
11. Hoseini kakhk SA, Khaleghzadeh H, Nematy M, Hamedinia M. The effect of combined aerobic- resistance training on lipid profile and liver enzymes in patients with non-alcoholic fatty liver under nutrition diet. Sport Physiol 2015; 27(7): 65-84. [in Persian]
12. Johnson NA, George J. Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease. Hepatology 2010; 52(1): 370-81.
13. Reddy JK, Rao MS. Lipid Metabolism & Liver Inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 2006; 290(5): G852-8.
14. Sreenivasa Baba C, Alexander G, Kalyani B, Pandey R, Rastogi S, Pandey A, et al. Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis. J Gastroenterol Hepatol 2006; 21(1 Pt 1): 191-8.
15. Bremer AA, Jialal I. Adipose tissue dysfunction in nascent metabolic syndrome. J Obes 2013; 2013: 393192.
16. Chen ZW, Chen LY, Dai HL, Chen JH, Fang LZ. Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease. J Zhejiang Univ Sci B 2008; 9(8): 616-22.
17. Nikroo H, Nematy M, Sima HR, Attarzade Hosseini SR, Pezeshki Rad M, Esmaeilzadeh A, et al. Therapeutic Effects of Aerobic Exercise and Low-calorie Diet on Nonalcoholic Steatohepatitis. Govaresh 2013; 17(4): 245-53. [in Persian]
18. Ross R, Janssen I, Dawson J, Kungl AM, Kuk JL, Wong SL, et al. Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res 2004; 12(5): 789-98.
19. Sun MX, Huang XQ, Yan Y, Li BW, Zhong WJ, Chen JF, et al. One-hour after-school exercise ameliorates central adiposity and lipids in overweight Chinese adolescents: a randomized controlled trial. Chin Med J (Engl) 2011; 124(3): 323-9.
20. Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, et al. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol Endocrinol Metab 2011; 301(5): E1033-9.
21. Bateman LA, Slentz CA, Willis LH, Shields AT, Piner LW, Bales CW, et al. Comparison of aerobic versus resistance exercise training effects on metabolic syndrome (from the Studies of a Targeted Risk Reduction Intervention Through Defined Exercise - STRRIDE-AT/RT). Am J Cardiol 2011; 108(6): 838-44.
22. Paoli A. Resistance training: the multifaceted side of exercise. Am J Physiol Endocrinol Metab 2012; 302(3): E387.
23. Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, et al. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut 2011; 60(9): 1278-83.
24. Cheraghpour M, Ehrampoush E, Homayounfar R, Davoodi H, Zand H, Mimmiran P. The relationship between the immune system and the inflammatory mechanisms in obesity with insulin resistance. Iran J Nutrition Sci Food Technol 2013; 7(5): 723-35. [in Persian]
25. Schmitz-Peiffer C. Signalling aspects of insulin resistance in skeletal muscle: Mechanisms induced by lipid oversupply. Cell Signal 2000; 12(9-10): 583-94.
26. Azimidokht SMA, Mogharnasi M, Kargarshouroki MK, Zarezademehrizi AA. The effect of 8 weeks interval training on insulin resistance and lipid profiles in type 2 diabetic men treated with metformin. Sport Biosciences 2015; 7(3): 461-76. [in Persian]
27. Bonen A, Dohm GL, van Loon LJ. Lipid metabolism, exercise and insulin action. Essays Biochem 2006; 42: 47–59.
28. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M, et al. Aerobic exercise training improves insulin sessitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in over weight and obese girls. Metabolism 2005; 54(11): 1472-9.
29. Poirier P, Tremblay A, Broderick T, Catellier C, Tancrède G, Nadeau A. Impact of moderate aerobic exercise training on insulin sensitivity in type 2 diabetic men treated with oral hypoglycemic agents: is insulin sensitivity enhanced only in nonobese subjects?. Med Sci Monit 2002; 8(2): CR59–CR65.
30. Johnson NA, Sachinwalla T, Walton DW, Smith K, Armstrong A, Thompson MW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 2009; 50(4): 1105-12.
31. Ahmadizad S, Haghighi AH, Hamedinia MR. Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. Eur J Endocrinol 2007; 157(5): 625-31.
32. Fedewa MV, Gist NH, Evans EM, Dishman RK. Exercise and insulin resistance in youth: a meta-analysis. Pediatrics 2014; 133(1): e163-74.
33. Nichols TW. A review of fatty liver/NASH and liver cirrhosis: genetics, prevention, nutritional, behavioral modification, exercise, pharmaceutical, biophysics and biotech therapy. J Liver 2013; 3(144): 2167-0889.
34. de Piano A, de Mello MT, Sanches Pde L, da Silva PL, Campos RM, Carnier J, et al. Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents. Eur J Gastroenterol Hepatol 2012; 24(11): 1313-24.
35. Mozaffari-Khosravi H, Hosseinzadeh-Shamsi-Anar M, Salami M, Hadi Nodoushan H, Fallahzadeh H. The Effect a Single Mega Dose of Vitamin D on Pro-inflammatory Factors in Mothers with Gestational Diabetes Mellitus after Delivery. JSSU 2011; 19 (2): 242-56. [in Persian]
36. Tofighi A. Impact of Water Training on Serum Adiponectin Level and Insulin Resistance in Obese Postmenopausal Women. Iran J Endocrinol Metabolism 2010; 12 (3): 260-7. [in Persian]
37. Shetty GK, Economides PA, Horton ES, Mantzoros CS, Veves A. Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care 2004; 27(10): 2450-7.
38. Lago F, Dieguez C, Gómez- Reino J, Gualillo O. The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine Growth Factor Rev 2007; 18(3-4): 313-25.
39. Dubnov G, Brzezinski A, Berry EM. Weight control and the management of obesity after menopause: the role of physical activity. Maturitas 2003; 44(2): 89-101.
40. Goldstein BJ, Scalia RG, Ma XL. Protective vascular and myocardial effects of adiponectin. Nat Clin Pract Cardiovasc Med 2009; 6(1): 27-35.
41. Mohamed Taha M, Hamed El sayed S. Effect of Resistive Training on Serum Adiponectin and Liver Fat in Prediabetic Patients with Fatty Liver. Bull Fac Ph Th 2013; 18(1): 83-91.
42. Emamdost S, Faramarzi M, Bagheri L, Otadi K, Amiri M, Yazdani T. The effect of combined exercise training on plasma Leptin levels and hormonal factors in overweight men. Yafteh 2014; 16 (1): 79-90. [in Persian]
43. Otero M, Lago R, Lago F, Casanueva FF, Dieguez C, Gómez-Reino JJ, et al. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 2005; 579(2): 295-301.
44. Khorshidi D, Assarzadeh M, Beni MA, Azizbeigi K, Abedi B, Ezadi M. The Effect of a Period of Selective Aerobic Exercise on Serum Level of Leptin and Some Hormones in Obese Men. Annals Biological Res 2012; 3(3): 1415-23.
45. Lutoslawska G, Skierska E, Byszerwska-Szpocinska E. Plasma Leptin concentrations in Lean physically active males and females in regulation to body composition and metabolic variables. J Sports Med Phys Fitness 2004; 44: 200-6.
46. Abedi B,Abbasi-Bakhtiari R. The effect of a 12-week combined training program on serum leptin, C- reactive protein and the insulin resistance index in overweight men. Feyz 2015; 19(4): 293-301. [in Persian]
47. Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002; 26(11): 1407-33.
48. Wang Z, Zhou YT, Kakuma T, Lee Y, Kalra SP, Kalra PS, et al. Unger RH. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Biochem Biophys Res Commun 2000; 277(1): 20-6.
49. Ozcelik O, Celik H, Ayar A, Serhatlioglu S, Kelestimur H. Investigation of the influence of training status on the relationship between the acute exercise and serum leptin levels in obesefemales. Neuro Endocrinol Lett 2004; 25(5): 381-5.
50. Pasman WJ, Westerterp-Plantenga MS, Saris WH. The effect of exercise training on leptin levels in obese males. Am J Physiol 1998; 274(2 Pt 1): E280-6.
51. Ackel-D'Elia C, Carnier J, Bueno CR Jr, Campos RM, Sanches PL, Clemente AP, et al. Effects of different physical exercises on leptin concentration in obese adolescents. Int J Sports Med 2014; 35(2): 164-71.
52. Ara I, Perez-Gomez J, Vicente-Rodriguez G, Chavarren J, Dorado C, Calbet JA. Serum free testosterone, leptin and soluble leptin receptor changes in a 6-week strength-training programme. Br J Nutr 2006; 96(6): 1053-9.
53. Soori R, Khosravi N, Montazery Taleghani H. Hormonal adaptations to endurance training versus resistance training in postmenopause obese women: a randomized clinical trial. J Shahrekord Univ Med Sci 2013; 15 (6): 87-99. [in Persian]
54. Haghighi AH, Shojaee M, Hamedinia MR. Effects of aerobic training on serum leptin levels and iron status in obese women. Sport Biosciences 2014; 6(4): 415-34. [in Persian]
55. Kishali NF. Serum leptin level in healthy sedentary young men after a short-term exercise. Afr J Pharma Pharmacol 2011; 5(4): 522-6.
56. Sari R, Balci MK, Balci N, Karayalcin U. Acute effect of exercise on plasma leptin level and insulin resistance in obese women with stable caloric intake. Endocr Res 2007; 32(1-2): 9-17.
57. Boudou P, Sobngwi E, Mauvais-Jarvis F, Vexiau P, Gautier JF. Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. Eur J Endocrin 2003; 149(5): 421–4.
58. Azizi Masole M, Razmjou S, Rajabi H, Hedayati M, Ahmadi P. Effect of Vitamin-mineral Supplementation on Oxidative Stress and Plasma Cytokine Response After Strenuous Training in Female Elite Swimmers. Iran J Endocrinol Metabolism 2010; 12(4): 409-17. [in Persian]
59. Nayebifar S, Afzalpour ME, Saghebjoo M, Hedayati M, Shirzaee P. The effect of aerobic and resistance trainings on serum C-Reactive Protein, lipid profile and body composition in overweight women. Mod Care J 2012; 8(4): 186-96. [in Persian]
60. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95(5): 2409-15.
61. Taghdir M, Djazayeri SA, Djalali M, Ashourpour M, Sepandi M, Rajab A. Relationship Between Serum Leptin Concentration and Inflammatory Factors and Oxidative stress in Postmenopausal Type II Diabetic Women. Endocrinol Metab 2009; 11(4): 371-76. [in Persian]
62. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta 2010; 411(11): 785-93.
63. Goldhammer E, Tanchilevitch A, Maor I, Beniamini Y, Rosenschein U, Sagiv M. Exercise training modulates cytokines activity in coronary heart disease patients. Int J Cardiol 2005; 100(1): 93-9.
64. Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 2010; 20(8):608-17.
65. Kohut ML, McCann DA, Russell DW, Konopka DN, Cunnick JE, Franke WD, et al. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun 2006; 20(3): 201-9.
66. Libardi CA, De Souza GV, Cavaglieri CR, Madruga VA, Chacon-Mikahil MP. Effect of resistance, endurance, and concurrent training on TNF-α, IL-6, and CRP. Med Sci Sports Exerc 2012; 44(1): 50-6.
67. Ghasemalipour H, Eizadi M, Hajirasouli M. The Effect of Regular Aerobic Training on Tumor Necrosis Factor-Alpha (TNF-α) in Males with Type II Diabetes. Avicenna J Med Biochem 2015; 3(1): e26908.
68. Riesco E, Tessier S, Lacaille M, Pérusse F, Côté M, Després JP, et al. Impact of a moderate-intensity walking program on cardiomet‌abolic risk markers in overweight to obese women: is there any influence of menopause?. Menopause 2013; 20(2): 185–93.
69. Taheri Kalani A, Nikseresht M. The Effect of 10 Weeks Resistance and Aerobic Training on Inflammatory Cytokines in Sedentary Overweight Men. J Ilam Univ Med Sci 2015; 23(5): 17-26. [in Persian]
70. Masoodsinaki H, Nazarali P, Hanachi P. Evaluation and impact of omega-3 supplementation with a period of selective aerobic exercise on liver enzymes (AST-ALT) of active student girls. J Hormozgan Univ Med Sci 2014; 18(3): 247-256. [in Persian]
71. Bashiri J, Hadi H, Bashiri M, Nikbakht H, Gaeini A. Effect of Concurrent Creatine Monohydrate Ingestion and Resistance Training on Hepatic Enzymes Activity Levels in Non-Athlete Males. Iran J Endocrinol Metab 2010; 12(1): 42-7. [in Persian]
72. Mir A, Aminai M, Marefati H. The impression of aerobic exercises to enzymes measure and liver fat in the man suffering to non-alcoholic fatty liver. Int Res J Appl Basic Sci 2012; 3(9): 1897-901.
73. Bae JC, Suh S, Park SE, Rhee EJ, Park CY, Oh KW, et al. Regular exercise is associated with a reduction in the risk of NAFLD and decreased liver enzymes in individuals with NAFLD independent of obesity in Korean adults. PLoS One 2012; 7(10): e46819SSS.
74. Davoodi M, Moosavi H, Nikbakht M. The effect of eight weeks selected aerobic exercise on liver parenchyma and liver enzymes (AST, ALT) of fat liver patients. J Shahrekord Univ Med Sci 2012; 14(1): 84-90. [in Persian]
75. Shamsoddini A, Sobhani V, Ghamar Chehreh ME, Alavian SM, Zaree A. Effect of Aerobic and Resistance Exercise Training on Liver Enzymes and Hepatic Fat in Iranian Men with Nonalcoholic Fatty Liver Disease. Hepat Mon 2015; 15(10): e31434.
76. Devries MC, Samjoo IA, Hamadeh MJ, Tarnopolsky MA. Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women. Obesity (Silver Spring) 2008; 16(10): 2281-8.
77. Barani F, Afzalpour ME, Ilbeigi S, Kazemi T, Mohammadi Fard M. The effect of resistance and combined exercise on serum levels of the liver enzymes and fitness indicators in nonalcoholic women with fatty liver disease. J Birjand Univ Med Sci 2014; 21(2): 188-202. [in Persian]
78. Dumortier M, Brandou F, Perez-Martin A, Fedou C, Mercier J, Brun JF. Low intensity endurance exercise targeted for lipid oxidation improves body composition and insulin sensitivity in patients with themetabolic syndrome. Diabetes Metab 2003; 29(5): 509-18.
79. Taylor R. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia 2008; 51(10): 1781-9.
80. Lavoie JM, Gauthier MS. Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise. Cell Mol Life Sci 2006; 63(12):1393-409.
81. Kobayashi J, Murase Y, Asano A, Nohara A, Kawashiri MA, Inazu A, et al. Effect of walking with a pedometer on serum lipid and adiponectin levels in Japanese middle-aged men. J Atheroscler Thromb 2006; 13(4): 197-201.
82. Polak J, Klimcakova E, Moro C, Viguerie N, Berlan M, Hejnova J, et al. Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women. Metabolism 2006; 55(10): 1375-81.
83. Auerbach P, Nordby P, Bendtsen LQ, Mehlsen JL, Basnet SK, Vestergaard H, et al. Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men. Am J Physiol Regul Integr Comp Physiol 2013; 305(5): R490–8.
84. Kraemer RR, Castracane VD. Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Exp Biol Med (Maywood) 2007; 232(2): 184–94.
85. Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, et al. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab 2005; 90(11): 5970-7.
86. Shahidi F, Pirhadi S. The effect of physical exercise and training on serum leptin levels. RJ MS 2014; 21(1256): 1-14. [in Persian]
87. Tadibi V, Behpour N, Rahimi MA, Rashidi S, Delbari ME, Usefipour P, et al. Comparison of the effect of 8 weeks of aerobic and combined training on serum levels of leptin and glucose in type 2 diabetic men. J Gorgan Univ Med Sci 2015; 17(1): 6-13. [in Persian]
88. Zilaei Bouri Sh, Khedri A, Ahangar pour A, Zilaei Bouri M. Comparing the Effects of Aerobic Exercises of High and Moderate Intensity on Serum Leptin Levels and Capacity of Fat Oxidation among Young Obese Girls. J Fasa Univ Med Sci 2013; 3(1): 81-7. [in Persian]
89. Oh S, Tanaka K, Warabi E, Shoda J. Exercise reduces inflammation and oxidative stress in obesity-related liver diseases. Med Sci Sports Exerc 2013; 45(12): 2214-22.
90. Soltani F, Daryanoosh F, Salesi M, Mohamadi M, Jafari H, Soltani A. The Effect of Eight Weeks of Aerobic Exercises on Visfatin, IL-6 and TNF-α in Female Sprague Dawley Rats. ZUMS J 2014; 21(89): 30-9.[in Persian]
91. Mathur N, Pedersen BK. Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm 2008; 2008: 109502.
92. Jorge ML, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz AL, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism 2011; 60(9): 1244-52.
93. Ogawa K, Sanada K, Machida S, Okutsu M, Suzuki K. Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women. Mediators Inflamm 2010; 2010: 171023.
94. Huffman KM, Slentz CA, Bales CW, Houmard JA, Kraus WE. Relationship between adipose tissue and cytokine responses to a randomized controlled exercise training intervention. Metabolism 2008; 57(4): 577-83.
95. St George A, Bauman A, Johnston A, Farrell G, Chey T, George J. Independent effects of physical activity in patients with nonalcoholic fatty liver disease. Hepatology 2009; 50(1): 68-76.
96. Safarzadeh A, Hajizadeh Rostami M, Talebi Garakani E, Fathi R. The Effect of Progressive Resistance Training on Serum Concentrations of Omentin-1 and Lipid Profile in Male Rats. Sport Biosciences 2014; 6(3): 287-300. [in Persian]
97. Tresierras MA, Balady GJ. Resistance training in the treatment of diabetes and obesity: mechanisms and outcomes. J Cardiopulm Rehabil Prev 2009; 29(2): 67-75.
98. Krisan AD, Collins DE, Crain AM, Kwong CC, Singh MK, Bernard JR, et al. Resistance training enhances components of the insulin signaling cascade in normal and high-fat-fed rodent skeletal muscle. J Appl Physiol (1985) 2004; 96(5):1691-700.
99. Abadi NGB, Marandi SM, Mojtahedi H, Esfrjany F. Effects of Aerobic Exercise Intensity on Serum Leptin Levels in Obese/Overweight Women. Isfahan Med Sch J 2012; 30(183): 393-400. [in Persian]
100. Atashak S, Azrbayjany MA, Sharafi H. Effect of three-months progressive resistance training on leptin and interleukin-6 concentration in obese men. Pejouhandeh 2011; 16(4): 154-61. [in Persian]
101. Safarzade AR, Gharakhanlou R, Hedayati M, Talebi-Garakani E. The Effect of 4 Weeks Resistance Training on Serum Vaspin, Il-6, CRP and TNF-Α Concentrations in Diabetic Rats. Iran J Endocrinol Metab 2012; 14(1): 68-74. [in Persian]
102. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature Rev Immunol 2011; 11(9): 607-15.
103. Abdelkader SM. Aerobic versus resistance exercise training in modulation of insulin resistance, adipocytokines and inflammatory cytokine levels in obese type 2 diabetic patients. J Adv Res 2011; 2(2): 179-83.
104. Ferreira FC, de Medeiros AI, Nicioli C, Nunes JE, Shiguemoto GE, Prestes J, et al. Circuit resistance training in sedentary women: body composition and serum cytokine levels. Appl Physiol Nutr Metab 2010; 35(2): 163–171.
105. Levinger I, Goodman C, Peake J, Garnham A, Hare DL, Jerums G, et al. Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors. Diabet Med 2009; 26(3): 220-7.
106. Vosoughi V, Moradi F, Aghaalinejad H, Peeri M. Effect of Strength Training on CRP, TNF-α, Muscular Strength, and Cardio -Respiratory Function in Inactive Adolescent Girls. Rafsanjan Univ Med Sci 2015; 14(2): 85-98. [in Persian]
107. Bahari S, Faramarzi M, Azamian Jazi A, Cheragh Cheshm M. The Effect of 8Week Resistance Training on Resting Level of Liver Inflammatory Markersand Insulin Resistanceof Type 2Diabetic Women. Armaghane-danesh 2014; 19(5): 450-61. [in Persian]
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moosavi-Sohroforouzani A, Ganbarzadeh M. Reviewing the physiological effects of aerobic and resistance training on insulin resistance and some biomarkers in non-alcoholic fatty liver disease . Feyz. 2016; 20 (3) :282-296
URL: http://feyz.kaums.ac.ir/article-1-3091-en.html

Volume 20, Issue 3 (Bimonthly 2016) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3781