:: Volume 20, Issue 3 (Bimonthly 2016) ::
Feyz 2016, 20(3): 274-281 Back to browse issues page
Determination of hepatitis B surface antibody and gamma interferon responsiveness in vaccinated personnel reffered to a health network in Dashte-e Azadegan (Khozestan province)
Sori Heidari, Seyedeh Elham Rezatofighi *, Mohammad Roayaei-Ardakani, Mohammad Reza Akhond
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran.
Abstract:   (2517 Views)

Background: Among the preventing measures for hepatitis B is vaccination against the virus. This study aimed to determine the antibody level against the hepatitis B surface antigen (anti-HBs) and its relation to interferon gamma (IFN-γ) level among the vaccinated staffs and also the reasons for the lack of response in such persons.

Materials and Methods: This cross-sectional study was done on vaccinated staff (n=130) referred to Shahid Chamran Hospital. Using ELISA the samples were studied for anti-HBsAb and INF-γ level. Then, the relationship between antibody level and some indexes (e.g. sex, age, BMI, number of vaccine doses, time past after the last dose and   INF-γ level) was considered.

Results: Among the studied participants, 68.5% and 31.5% had a perfect and failure of immunity response (>10 IU/ml and <10 IU/ml, respectively). There was a direct relationship between the INF-γ and anti-HBs titration (R=0.635). In addition, there was a significant relationship (P<0.05) between anti-HBs titer and some indexes (e.g. BMI, the number of doses and the time interval since the last dose of vaccine); however, no significant relationship was observed between the sex and age on one hand and antibody titration on the other hand.

Conclusion: Failure in INF-γ production against the virus can have a role in immunity response. Hence, measuring the anti-HBs level following the vaccination and also 5 years after are suggested for high risk cases; then, upon which a decision can be made on the reminder dosage.

Keywords: Hepatitis B, Vaccination, Gamma interferon, Antibody, Personnel
Full-Text [PDF 279 kb]   (691 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/08/13 | Accepted: 2016/08/13 | Published: 2016/08/13
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