[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 3 (Bimonthly 2016) ::
Feyz 2016, 20(3): 274-281 Back to browse issues page
Determination of hepatitis B surface antibody and gamma interferon responsiveness in vaccinated personnel reffered to a health network in Dashte-e Azadegan (Khozestan province)
Sori Heidari, Seyedeh Elham Rezatofighi *, Mohammad Roayaei-Ardakani, Mohammad Reza Akhond
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran.
Abstract:   (2520 Views)

Background: Among the preventing measures for hepatitis B is vaccination against the virus. This study aimed to determine the antibody level against the hepatitis B surface antigen (anti-HBs) and its relation to interferon gamma (IFN-γ) level among the vaccinated staffs and also the reasons for the lack of response in such persons.

Materials and Methods: This cross-sectional study was done on vaccinated staff (n=130) referred to Shahid Chamran Hospital. Using ELISA the samples were studied for anti-HBsAb and INF-γ level. Then, the relationship between antibody level and some indexes (e.g. sex, age, BMI, number of vaccine doses, time past after the last dose and   INF-γ level) was considered.

Results: Among the studied participants, 68.5% and 31.5% had a perfect and failure of immunity response (>10 IU/ml and <10 IU/ml, respectively). There was a direct relationship between the INF-γ and anti-HBs titration (R=0.635). In addition, there was a significant relationship (P<0.05) between anti-HBs titer and some indexes (e.g. BMI, the number of doses and the time interval since the last dose of vaccine); however, no significant relationship was observed between the sex and age on one hand and antibody titration on the other hand.

Conclusion: Failure in INF-γ production against the virus can have a role in immunity response. Hence, measuring the anti-HBs level following the vaccination and also 5 years after are suggested for high risk cases; then, upon which a decision can be made on the reminder dosage.

Keywords: Hepatitis B, Vaccination, Gamma interferon, Antibody, Personnel
Full-Text [PDF 279 kb]   (691 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/08/13 | Accepted: 2016/08/13 | Published: 2016/08/13
1. Werner JM, Abdalla A, Gara N, Ghany MG, Rehermann B. The Hepatitis B Vaccine Protects Re-Exposed Healthcare Workers, but Does Not Provide Sterilizing Immunity. Gastroenterology 2013; 145(5): 1-16.
2. Sarmast Shooshtari MH, Makvandi M, Rasti M, Neisi N, Rastegarvand N, Pouremamali A, et al. Evaluation of hepatitis B surface antibody and specific gamma interferon response in health care workers after vaccination. Jundishapur J Microbiol 2014; 8(1): e13801.
3. Momen Heravi M, Sharif A, Moosavi S. Evaluation of Anti HBs antibody in vaccinated personnels of Beheshti hospital in Kashan. Feyz 2006; 10 (1): 11-14. [in Persian]
4. Kazemeini SK, Owlia F. Determination of HBs Antibody Titre in Vaccinated Health Care Workers of Shahid Sadoughi Burn Hospital in Yazd in 2011. Toloo-e-behdasht 2013; 12 (1): 155-63. [in Persian]
5. Davoud-zadeh M, Rajabi poor F, Shafi-zadeh F, Ghorbani vagheie A. Determination of HbsAb level in vaccinized medical students of Lorestan University of Medical Sciences in Autumn 2004. Yafteh 2005; 6(4): 57-61. [in Persian]
6. Shokrgozar MA, Shokri F. HLA- associated antibody response to recombinant hepatitis B vaccine in healthy Iranian adults. Iran J Med Sci 1999; 24(3-4): 98-103.
7. Albarran B, Goncalves L, Salmen S, Borges L, Fields H, Soyano A, et al. Profiles of NK, NKT cell activation and cytokine production following vaccination against hepatitis B. APMIS 2005; 113(7-8): 526-35.
8. Schillie S, Murphy TV, Sawyer M, Ly K, Hughes E, Jiles R, et al. CDC guidance for evaluating health-care personnel for hepatitis B virus protection and for administering post exposure management. MMWR Recomm Rep 2013; 62(RR-10): 1-19.
9. WHO. Hepatitis B, Fact sheet N°204, July 2013, World Health Organization. Available at: http://www.who.int/mediacentre/ factsheets/fs204/en/
10. Sarkari B, Zargar M, Mohammad R, Asgarian S. Prevalence of Hepatitis B Antibodies in Health-Care Workers in Yasuj Hospitals. Armaghane Danesh 2007; 11(4): 97-106. [in Persian]
11. Kazemi H, Yadegarynia D, Rashk H. The relation between hepatitis B antibody and number of hepatits B vaccinations in the personnel of a hospital in Tehran. Res Med 2011; 35(2): 114-8. [in Persian]
12. Nooshiravanpour P, Ramazenkhani A, Gashani M, Khodakarim S, Hatami H. Immunity against hepatitis-B among freshman students at Shahid Beheshti University of Medical Sciences, academic year 2012-2013. Res Med 2014; 38(3): 176-80. [in Persian]
13. Meyguni SS, Mikaeili B, Eskandari M, Momeni M. Determination of anti Hepatitis B surface Antibody Titer in Health Care Workers of Two Hospital in Hamedan in 2011. J Nurse Physician Within War 2011; 0(15 and 16): 5-7. [in Persian]
14. Chen S, Akbar SM, Miyake T, Abe M, Al-Mahtab M, Furukawa S, et al. Diminished immune response to vaccinations in obesity: role of myeloid-derived suppressor and other myeloid cells. Obes Res Clin Pract 2015; 9(1): 35-44.
15. Darvish Moghaddam S, Zahedi MJ, Yazdani R. Persistence of immune response after hepatitis vaccination in medical students and residents. Arch Iran Med 2004; 7(1): 37-40.
16. Izadpanah A, Mashreghy Moghadam H, Ziaee M, Foadaldini M, Ebadian F. Anti HBs level in nursing staff of Birjand University of Medical Sciences. J Birjand Univ Med Sci 2008; 15(2): 80-5. [in Persian]
17. Jafarzadeh A. The Factors Influencing the Immune Response to Hepatitis B Vaccine and Persistence of the Protection. J Rafsanjan Univ Med Sci 2002; 1(2): 126-36. [in Persian]
18. Vingerhoets J, Vanham G, Kestens L, Penne G, Leroux-Roels G, Gigase P. Deficient T-cell response in non-respondrs to hepatitis B vaccination: absence of TH1 cytokine production. Immunol Lett 1994; 39(2): 163-8.
19. Chedid MG, Deulofeut H, Yunis DE, Lara-Marquez ML, Salazar M, Deulofeut R, et al. Defect in Th1- like cells of non- responders to hepatitis B vaccine. Human Immunol 1997; 58(1): 42-7.
20. Larsen CE, Xu J, Lee S, Dubey DP, Uko G, Yunis EJ, Alper CA. Complex cytokine responses to hepatitis B surface antigen and tetanus toxiod in responders, nonresponders and subjects naive to hepatitis B surface antigen. Vaccine 2000; 18(26): 3021-30.
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Heidari S, Rezatofighi S E, Roayaei-Ardakani M, Akhond M R. Determination of hepatitis B surface antibody and gamma interferon responsiveness in vaccinated personnel reffered to a health network in Dashte-e Azadegan (Khozestan province). Feyz. 2016; 20 (3) :274-281
URL: http://feyz.kaums.ac.ir/article-1-3090-en.html

Volume 20, Issue 3 (Bimonthly 2016) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 4162