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:: Volume 20, Issue 3 (Bimonthly 2016) ::
Feyz 2016, 20(3): 221-227 Back to browse issues page
Effect of hydro-alcoholic extract of Aloe vera L. on polycystic ovary syndrome in rat
Vahid Hemayatkhah-Jahromi , Mahnaz Rahmanian-Koushkaki
Department of Biology, Jahrom Branch, Islamic Azad Unversity, Jahrom, I. R. Iran. , dr.hemayatkhah@yahoo.com
Abstract:   (7465 Views)

Background: Polycystic ovary syndrome (PCOS) that afflicts 10 percent of infertile women   is the most important reason for the cessation of ovulation. So the purpose of this study was to investigate the effect of hydro-alcoholic extract of Aloe vera L. on the treatment of PCOS in rat.

Materials and Methods: This experimental study was carried out on Wistar rats (n=35, weight: 180±20 g) with 2-3 consecutive estrous cycle. Then rats were divided to 5 groups: Control group; PCOS group (Stradiolvalerate 4 mg/kg/im); Experimental 1,2 and 3 groups (Stradiolvalerate 4 mg/kg/im+Aloe vera L. extract 100, 200 and 400 mg/kg/ip, respectively). After 21 days blood samples were taken to measure the concentration of estrogen and progesterone hormones. Findings were analyzed using ANOVA and Duncan statistical tests at the significant level of P<0.05.

Results: The results showed a significant increment in PCOS group and decrement in the Experimental 2 and 3 groups in estrogen concentration compared to the Control group, respectively (P<0.05). The concentration of progesterone hormone in PCOS group and the Experimental groups were significantly decreased compared to the Control group (P<0.05).

Conclusions: The hydro-alcoholic extract of Aloe vera L. decreased and increased the concentration of estrogen and progesterone hormone in rat, respectively. So it appears that the use of Aloe vera L. would be effective in the treatment of infertility disorders and PCOS.

Keywords: Aloe vera L., Estrogen, Progesterone, Polycystic, Rat
Full-Text [PDF 230 kb]   (1741 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/08/9 | Revised: 2017/08/2 | Accepted: 2016/08/9 | Published: 2016/08/9
References
1. Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005; 352:1223-36.
2. Gibbs RS, Karlan BY, Haney AF, Nygaard I. Danforth Obstetrics and Gynecology, 10th ed. St. Lippincott:Williams & Wilkins; 2008. p. 705-24.
3. Kumkum A, Jasmine K, Shweta G, Pal Ajeshwar N. Hyper prolactinemia and its correlation with hypothyroidism in infertile women. J Obstet Gynecol India 2006; 56(1): 68-71.
4. Novak E, Berek JS. Berek & Novaks Gynecology. 14th ed. St. Philadelphia: Lipplincott Williams & Wilkins Edition; Ghazi Jahani B, Zonuzi A, Bahrani N. 2th ed. Tehran: Golbannashr Co; 2007. p. 1006-7.
5. Forozanfard F. Ovulation step by step. Printing, Publishing Kashan Morsel 2009; 81-105. [in Persian]
6. Adlercreutz H, Mazur W. Phytoestrogens and Western diseases. Ann Med 1997; 29(2): 95-120.
7. Dana N, Haghjoy Javanmardi SH, Asgari S, Asnaashari H, Abdian N. Anti-atherosclerosis effects os Aloe vera gel on rabbit hypercholesterolemia. J Babol Univ Med Sci 2012; 37-44. [in Persian]
8. Ahmadi R, Tavakoli P, Mafi M. The combined effect of Aloe vera extract and immobilization stress on serum levels of LH, FSH and testosterone in male rats. Bimonthly J Med Daneshvar / University shahed 2012; 19(98). [in Persian].
9. Erfanimajd N, Bahrami M, Morovati H. Study the protective effect of Aloe vera and histometrical testicular histopathological changes induced diabetic rats. J Iran Veterinary 2013; 9(2): 78-88. [in Persian]
10. Saks D, Barkaia GR. Aloe vera gel activity against plant pathoyenic fungi. Postharvest Biologyy Technol 1995; 6:(1,2): 159-65.
11. Brakia GR, Phillips D. Postharvest heat treatment of fresh fruit and vegetables for decay control. J Plant Dis 1991; 75: 1085-9.
12. Jafari BM, Khaksar Z, Sharifi A, Mahmoudi R. Effect of Aloe vera extract on ovaries development in during gestationt age of 18 day embryo of diabetic rats. Life Sci J 2013; lo(2S). [in Persian]
13. Ayubi A, Omidi A, Valizade R, Mosaee A. Compare the effect of Aloe vera extract and Teucrium polium lipid metabolism in streptozotocin- induced diabetic rats. J Birjand Univ Med Sci 2013; 20(2): 144-52. [in Persian]
14. Bown D. Encylopedia of herbs. Dorling Kinder selylimted. London 1995; 235.
15. Brawer JR, Munoz M, Farookhi R. Development of the polycystic ovarian condition (PCOS) in the estradiol valerate-terated rate. Biolrepord 1986; 35: 647-55.
16. Schulster A, Farookhi R, Brawer JR. Polycystic ovarian condition in esteradiol valerate treated rate: spontaneous changes in characteristic endocrine features. Biol Repord 1984; 31:587-93.
17. Marx TL, Mehta AE. Polycystic ovary syndrome: pathogenesis and treatment over the short and long term. Cleveland Clin J Med 2003; 70: 31-45.
18. Jelodar GH, Askari K. Effect of Vitex fruit extract on changes of sex hormones in polycystic ovary syndrome (PCOS) induction in the rat. Physiol Pharmacol 2011; 16 (1): 62-9. [in Persian]
19. Jelodar GH, Karami A. Effect of fruit extract five fingers on changes in ovarian tissue in polycystic ovary syndrome (PCOS) induction in the rat. J Babol Univ Med Sci 2012; 15 (3): 96-102. [in Persian]
20. Pourfarid M, Karimijashni HA, Hoshmand F. Effect of Aloe vera plant extract on the serum levels of the hormones estrogen, progesterone and gonadotropins in rats. J Jahrom Univ Med Sci 2012; 10 (4): 7-12. [in Persian]
21. Telefo PB, Moundipa PF, Tchouanguep FM. Inductive effect of the leaf mixture extract of Aloe buettneri, Justicia insularis, Dicliptera verticillata and Hibiscus macranthus on in vitro production of estradiol. J Ethno Pharmacol 2004; 91(2-3): 225-30.
22. Kosif R, Akat G, Oztekin A. Microscopic examination of placenta of rats prenatally exposed to Aloe barbadensis: a preliminary study. Int J Morphol 2008; 26(2): 275-81.
23. Botes L, Van der Westhuizen FH, Loots du T. Phytochemical contents and antioxidant capacities of two Aloe greatheadii var. dayana extracts. Molecules 2008; 13(9): 2169-80.
24. Surjushe A, Vasani R, Saple DG. Aloe vera: a short review. Indian J Dermatol 2008; 53(4): 163-6.
25. Moshtaghi A, Johari H, Shariati M, Amiri J. The effect of palm pollen on estrogen, progesterone and gonadotropin in rats. J Rafsanjan Univ Med Sci 2010; 9(2): 117-24. [in Persian]
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Hemayatkhah-Jahromi V, Rahmanian-Koushkaki M. Effect of hydro-alcoholic extract of Aloe vera L. on polycystic ovary syndrome in rat. Feyz 2016; 20 (3) :221-227
URL: http://feyz.kaums.ac.ir/article-1-3079-en.html


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Volume 20, Issue 3 (Bimonthly 2016) Back to browse issues page
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