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:: Volume 20, Issue 2 (Bimonthly 2016) ::
Feyz 2016, 20(2): 118-124 Back to browse issues page
Effect of 8 weeks aerobic training on plasma apelin in male rats treated with L-NAME
Asieh Abbassi-Daloii , Ahmad Abdi , Hoda Yazdani-Tapesari , Mojtaba Salehpour , Zahra Rostami-Angasi , Behroz Yahyaei
Department of Exercise Physiology Ayatollah Amoli Branch, Islamic Azad University, Amol, I. R. Iran. , abbasi.daloii@gmail.com
Abstract:   (4398 Views)

Background: Evidence supports the systemic inflammation in obesity and insulin resistance. Apelin is secreted by adipose tissue and plays an important role in the inflammation process. The present study aimed to examine the effect of 8 weeks aerobic training on plasma Apelin in male rats treated with Nitro-L-Arginine-Methyl Ester (L-NAME).

Materials and Methods: In this experimental study male Wistar rats (n=24, age 20 months) were randomly assigned into four groups: Control, Training, TrainingS+L-NAME and L-NAME. An aerobic training protocol was performed for eight weeks, 5 times a week with an intensity of 75-80% of maximal oxygen consumption. The rats were sacrificed 72 hours after the last exercise session and blood samples were collected. Data were analyzed by ANOVA and Tukey post hoc test at P<0.05 significancy level.

Results: The results showed that plasma Apelin level did not change significantly after eight weeks of aerobic training compared to the Control group. However, the results showed that there was a significant difference in plasma Apelin between L-NAME and Control group (P<0.003). In addition, the results showed no significant difference between the insulin level and glucose in four groups.

Conclusion: It seems that with increasing age plasma Apelin level is not affected by aerobic exercise. However, nitric oxide inhibitors can reduce the plasma Apelin level.

Keywords: Aerobic training, L-NAME, Plasma apelin, Rat
Full-Text [PDF 181 kb]   (1692 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/06/16 | Revised: 2017/08/1 | Accepted: 2016/06/16 | Published: 2016/06/16
References
1. Deng Y, Scherer PE. Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann N Y Acad Sci 2010; 1212: 1-19.
2. Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A, et al. Apelin, a newly identified adipokine up- regulated by insulin and obesity. Endocrinology 2005; 146(4): 1764–71.
3. Carpéné C, Dray C, Attané C, Valet P, Portillo MP, Churruca I, et al. Expanding role for the apelin/APJ system in physiopathology. J Physiol Biochem 2007; 63(4): 359-73.
4. Frier BC, Williams DB, Wright DC. The effects of apelin treatment on skeletal muscle mitochondrial content. Am J Physiology-Regulatory, Integrative Comparative Physiol 2009; 297(6): 1761-8.
5. Dray C, Knauf C, Daviaud D, Waget A, Boucher J, Buléon M, et al. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab 2008; 8(5): 437-45.
6. Higaki Y, Hirshman MF, Fujii N, Goodyear LJ. Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle. Diabetes 2001; 50(2): 241–7.
7. Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S, et al. Regulatory Roles for APJ, A Seventransmembrane Receptor Related to Angiotensin-type 1 Receptor in Blood Pressure in Vivo. J Biol Chem 2004; 279(25): 26274-79.
8. Ashley E, Chun HJ, Quertermous T. Opposing cardiovascular roles for the angiotensin and apelin signaling pathways. J Mol Cell Cardiol 2006; 41(5): 778–81.
9. Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin sensitizing adipocytokine in obesity. Proc Natl Acad Sci U S A 2005; 102(30): 10610-5.
10. Mohebbi H, Rhmaninia F, Hedayati Emami MH, Saidi Ziabari T. Effects of 8-week moderate-intensity aerobic training on levels of plasma apelin and insulin resistance in women with type 2 diabetes. Sport Physiol 2014; 5(20): 115-28. [in Persian]
11. Aminilari Z, Daryanoosh F, Kooshki Jahromi M, Mohamadi M. The effect of 12 weeks aerobic exercise on the apelin, omentin and glucose in obese older women with diabetes type 2. Arak Med Univ J 2014; 17(85): 1-10. [in Persian]
12. Zhang J, Cai Xia Ren , Yong Fen Qi , Li Xia Lou , Li Chen , Li Ke Zhang, et al. Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. Life Sci 2006; 79: 1153–9.
13. Ma WY, Yu TY, Wei JN, Chi SH, Mao S L, Ying JL, et al. Plasma apelin: A novel biomarker for predicting diabetes. Clin Chim Acta 2014; 435: 18-23.
14. Saeidi Ziabari T, Mohebbi H, Rahmani nia F, Hedayati MH. Effects of 8-week moderate-intensity aerobic training on levels of plasma apelin and insulin resistance in women with type 2 diabetes. Sport Physiol 2014; 5(20): 115-28. [in Persian]
15. Varady KA, Tussing L, Bhutani S, Braunschweig CL. Degree of weight loss required to improve adipokine concentrations and decrease fat cell size in severely obese women. Metabolism 2009; 58(8): 1096-1.
16. Sheu WH, Chang TM, Lee WJ, Ou HC, Wu CM, Tseng LN, et al. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring) 2008; 16(5): 1033-8.
17. Xu S, Tsao PS, Yue P. Apelin and insulin resistance: another arrow for the quiver? J Diabetes 2011; 3(3): 225-31.
18. Daryanoosh F, Alizadeh Palavani H, Sherafati Moghadam M, Keshtkar Hesam Abadi B. Effects of long-term aerobic activity on plasma levels of apelin and omentin in rats. J Qazvin Univ Med Sci 2015; 19(5): 23-17.
19. Mahmoody SAA, Dabidi-Roshan V, Gharakhanlou R, Hedayati M. Improvement of Kidney Apelin and Apelin Receptor in Nitro-L-Arginine-Methyl Ester Induced Rats. ZJRMS 2015; 17 (2): 31-6.
20. Duparc T, Colom A, Cani PD, Massaly N, Rastrelli S, Drougard A, et al. Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice. Antioxid Redox Signal 2011; 15(6): 1477-96.
21. Baron AD, Zhu JS, Marshall S, Irsula O, Brechtel G, Keech C. Insulin resistance after hypertension induced by the nitric oxide synthesis inhibitor L-NMMA in rats. Am J Physiol 1995; 269(4 Pt 1): E709-15.
22. Balon TW, Nadler JL. Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol 1997; 82(1): 359-63.
23. Cabou C, Campistron G, Marsollier N, Leloup C, Cruciani-Guglielmacci C, Pénicaud L, et al. Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity. Diabetes 2008; 57(10): 2577-87.
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Abbassi-Daloii A, Abdi A, Yazdani-Tapesari H, Salehpour M, Rostami-Angasi Z, Yahyaei B. Effect of 8 weeks aerobic training on plasma apelin in male rats treated with L-NAME. Feyz 2016; 20 (2) :118-124
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Volume 20, Issue 2 (Bimonthly 2016) Back to browse issues page
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