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:: Volume 21, Issue 6 (Bimonthly 2017) ::
Feyz 2017, 21(6): 553-561 Back to browse issues page
The effect of silver nanoparticles covered with the Achillea biebersteinii plant extract on angiogenesis of chick chorioallantoic membrane
Parisa Zamani-Esmati , Javad Baharara *, Alireza Iranbakhsh , Tayebe Ramezani
Research Center for Animal Development Applied Biology and Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, I. R. Iran. , baharara78@gmail.com
Abstract:   (290 Views)
Background: Angiogenesis is a major event in many diseases such as cancer. Today, using silver nanoparticles in industry and medicine has taken into consideration. The Achillea biebersteinii extract has antibacterial, anti-inflammatory and antioxidant effects. The present study aimed at examining the effects of silver nanoparticles coated with the A. biebersteinii extract on angiogenesis of chick chorioallantoic membrane.
Materials and Methods: In this experimental study, 50 fertilized eggs Ross were randomly divided into 5 groups: the sham and experimental groups 1 to 4. In the second day of incubation, the window was opened on eggs and the eggs were treated with 50, 100, 150 and 200 μg/mL silver nanoparticles. At the twelfth day, the samples were photographed and the number and lengths of vessels around the sponges, the length of crown-rump, fetal weight and blood vessels' hemoglobin levels were recorded and compared with the control group.
Results: The results showed that the 50 μg/mL of silver nanoparticles had no significant effect on the angiogenesis process. However, 100,150 and 200 μg/mL of the nanoparticles doses-dependently decreased the number, length and content of hemoglobin in the blood vessels. Also, fetal weight and crown-rump in concentrations 150 and 200 μg/mL showed a significant decrease compared with the control group (P<0.01).
Conclusion: Silver nanoparticles coated with A. biebersteinii extracts can be considered in the studies of diseases associated with angiogenesis such as cancer.
Keywords: Angiogenesis, Chorioalantoic membrane, Silver nanoparticls, Achillea biebersteinii
Full-Text [PDF 516 kb]   (71 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/05/21 | Accepted: 2017/12/5 | Published: 2017/12/12
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Zamani-Esmati P, Baharara J, Iranbakhsh A, Ramezani T. The effect of silver nanoparticles covered with the Achillea biebersteinii plant extract on angiogenesis of chick chorioallantoic membrane . Feyz. 2017; 21 (6) :553-561
URL: http://feyz.kaums.ac.ir/article-1-3002-en.html


Volume 21, Issue 6 (Bimonthly 2017) Back to browse issues page
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