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:: Volume 20, Issue 1 (Bimonthly 2016) ::
Feyz 2016, 20(1): 96-99 Back to browse issues page
Presenting a case of primary splenic diffuse large B-cell lymphoma
Majid Ehsani *, Masoud Moeeni
Infectious Diseases Research Center , ehsanimajid21@gmail.com
Abstract:   (3805 Views)

Background: Primary splenic lymphoma approximately comprises 2% of all Non-Hodgkin’s lymphomas. Diffuse large B cell lymphoma, a rare disease, is responsible for 33% of primary splenic lymphomas. In this study a case of primary splenic diffuse large B-cell lymphoma is reported.

Case Report: The case is a 57 years old woman admitted because of weakness‚ malaise‚ abdominal fullness‚ early satiety and weight loss and no lymphadenopathy. Except for huge splenomegaly, no significant finding was found on her physical examination.

No positive finding was found for infections and inflammatory diseases in virology and serology tests. Bone marrow aspiration and biopsy were hypercellular. Except for huge spelenomegaly, central lymphadenopathy was not seen in chest and abdominopelvic CT.   The patient had anemia‚ elevated ESR‚ CRP‚ and LDH.

Based on findings, a diagnostic-therapeutic splenectomy was planed. Pathology tests reported a non-hodgkin’s diffuse large B cell lymphoma with a positive CD20 in mmunohistochemistry. Following spelenectomy the patient received chemotherapy (R- CHOP) regimen.

Conclusion: In classical approach to splenomegaly, after ruling out any common causes‚ primary splenic lymphoma must be kept in mind. Splenectomy in these patients is considered not only as a diagnostic‚ but also a therapeutic attempt.

Keywords: Splenic lymphoma, Non-hodgkin’s lymphoma, Diffuse large B cell lymphoma
Full-Text [PDF 143 kb]   (3217 Downloads)    
Type of Study: case report | Subject: medicine, paraclinic
Received: 2016/04/11 | Accepted: 2016/04/11 | Published: 2016/04/11
1. Kashimura M, Noro M, Akikusa B, Okuhara A, Momose S, Miura I, et al. Primary splenicDLBCL manifesting in red pulp. Virchows Arch 2008; 453(5): 501-9.
2. Kattepur AK, Rohith S, Shivaswamy BS, Babu R, Santhosh CS. Primary Splenic Lymphoma: A Case Report. Indian J Surg Oncol 2013; 4(3): 287-90.
3. Doshi K, Stanciu J, Cervantes J, Rodrigues L, Gintautas J, Alwani A. Splenic Non- Hodgkin’s lymphoma presenting as recurrent kidney stones-anincidentaloma. Proc West Pharmacol Soc 2008; 51: 55–7
4. Wu CM, Cheng LC, Lo GH, Lai KH, Cheng CL, Pan WC. Malignant lymphoma ofspleen presenting as acute pancreatitis. World J Gastroenterol 2007; 13(27): 3773-75.
5. Dasgupta T, Coombes B, Brasfield RD. Primary malignant neoplasms of the spleen. Surg Gynecol Obstet 1965; 120: 947–60.
6. Skarin AT, Davey FR, Moloney WC. Lymphosarcoma of the spleen. Arch Intern Med 1971; 127(2): 259-65.
7. Kraemer BB, Osborne BM, Butler JJ. Primary splenic presentation of malignant lymphoma and related disorders- a study of 49 cases. Cancer 1984; 54(8): 1606–19.
8. Pileri SA, Dirnhofer S, Went P, Ascani S, Sabattini E, Marafioti T, et al. Diffuse large B-cell lymphoma: one or more entities? Present controversies and possible tools for its subclassification. Histopathology 2002; 41(6): 482-509.
9. MacGill M. Lymphoma: Causes, Symptoms and Research. 2016.Available at: http://www.medicalnewstoday.com/ articles/146136.php
10. VanVliet J. Primary DLBCL spleen. J Diagnostic Medical Sonography 2010; 26(3): 147–9.
11. Paes F, Kalkanis D, Sideras P, SerafiniA. FDG PET/CT of extra-nodal involvement in Non-Hodgkin lymphoma and Hodgkindisease. Radio Graphics 2010; 30: 269–91.
12. Konstantiadou I, Mastoraki A, Papanikolaou I, Sakorafas G, Safioleas M. Surgical approach of primary splenic lymphoma: Report of a case and review of literature. Indian J Hematol Blood Transfus 2009; 25(3): 120–4.
13. Iannitto E, Tripodo C. How I diagnose and treat spleniclymphomas. Blood 2011; 117(9): 2585–95.
14. Kim JK, Hahn JS, Kim GE, Yang WI. Three cases of diffuselarge B-cell lymphoma presenting as primary splenic lymphoma. Yonsei Med J 2005; 46(5): 703–9.
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Ehsani M, Moeeni M. Presenting a case of primary splenic diffuse large B-cell lymphoma. Feyz. 2016; 20 (1) :96-99
URL: http://feyz.kaums.ac.ir/article-1-2969-en.html

Volume 20, Issue 1 (Bimonthly 2016) Back to browse issues page
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