Background: Adipolin (CTRP12) is a novel anti-inflammatory adipocytokine secreted from adipose tissue, which improves insulin sensitivity. The aim of this study was to examine the effect of aerobic training on serum adipolin levels and insulin resistance index (HOMA-IR) in overweight men.

Materials and Methods: In this semi experimental study, which was conducted in one of the sport complexes of Khorramabad in spring 2014, 26 sedentary overweight men (body mass index (BMI)>25 Kg/m2, age range 35-50 years) were selected and randomly allocated into the experimental (n=13) and control (n=13) groups. Subjects in the experimental group participated in 10 weeks of aerobic training at 50%-70% of the maximal heart rate, 30-45 minutes per session and three sessions per week. Levels of adipolin, insulin and fasting glucose and anthropometric indices were measured before and 72 hours after the last training session.

Results: Serum levels of adipolin, insulin, fasting glucose and HOMA-IR did not significantly change following 10 weeks of aerobic training (P>0.05). However, weight (P=0.001), BMI (P=0.001) and fat percentage (P=0.001) were decreased significantly. Furthermore, changes in adipolin levels following 10 weeks of aerobic training were significantly correlated with changes in BMI (P=0.028, r=0.606).

Conclusion: A 10-week aerobic training program has no effects on serum levels of adipolin in sedentary overweight men and these findings are in accordance to insulin resistance changes.