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:: Volume 19, Issue 6 (Bimonthly 2016) ::
Feyz 2016, 19(6): 486-494 Back to browse issues page
Comparison of the antibacterial effects of Persica, Matrica and chlorhexidine gluconate mouthwashes and normal saline in mechanically ventilated ICU patients: A clinical trial
Abolfazl Firouzian, Hadi Darvishi-Khezri *
Sari Branch, Islamic Azad University , Hadidarvishi@iausari.ac.ir
Abstract:   (2060 Views)

Background: Bacterial colonization in the pharynx is one of the most important risk factors for ventilator-associated pneumonia. The aim of this study was to determine and compare the anti-bacterial effects of different mouthwashes in mechanically ventilated patients.

Materials and Methods: In this double-blind randomized clinical trial, 80 patients were selected from the intensive care units (ICUs) of Imam Khomeini Hospital in Sari City, Iran, during 2010-2011, and were divided into four groups of 20 cases. The first intervention group was administered with chlorhexidine gluconate (CHX) 0.2% mouthwash, the second group Persica herbal 10% mouthwash, the third group was administered with Matrica 10% and finally in the fourth group, normal saline was used. In order to culture Staphylococcus aureus and Streptococcus pneumoniae, oropharynx samples were obtained without any stimulation prior and 6 min following oral rinsing.

Results: Bacterial colonies were decreased significantly after the intervention in all four groups (P<0.001). Chlorhexidine gluconate, Persica and Matrica mouthwashes caused to decrease the Staphylococcus aureus (P<0.001, P<0.008 and P=0.01, respectively) and Streptococcus pneumoniae (P<0.001) positive cultures after the intervention.

Conclusion: Herbal oral mouthwashes including Persica and Matrica are effective in decreasing Staphylococcus aureus and Streptococcus pneumoniae colonized in the oropharynx of mechanically ventilated patients. Therefore, after further investigations, they can serve as suitable alternatives for CHX in ICU settings.

Keywords: Mouthwashes, Chlorhexidine, Persica, Matrica, Normal Saline, Intensive Care Unit, Mechanical ventilation
Full-Text [PDF 297 kb]   (844 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/02/4 | Accepted: 2016/02/4 | Published: 2016/02/4
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Firouzian A, Darvishi-Khezri H. Comparison of the antibacterial effects of Persica, Matrica and chlorhexidine gluconate mouthwashes and normal saline in mechanically ventilated ICU patients: A clinical trial. Feyz. 2016; 19 (6) :486-494
URL: http://feyz.kaums.ac.ir/article-1-2916-en.html


Volume 19, Issue 6 (Bimonthly 2016) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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