Background: Diabetic foot ulcers are one of the main health problems in diabetic patients. Nowadays, there are several ways for the treatment of diabetic foot ulcers, but some patients with bone destruction are still forced to amputation. Here, we report a rare case of complete reconstruction of osteomyelitis-induced bone degeneration using ANGIPARS in diabetic foot ulcer.

Case Report: A 59-year-old man with a history of type 2 diabetes mellitus presents to Kashan Shahid-Beheshti hospital, Iran, with a diabetic foot ulcer (3cm × 2cm) in his right thumb. Foot X-ray revealed complete resorption of the distal phalanx. The patient received parenteral broad-spectrum antibiotics including meropenem, vancomycin and ciprofloxacin, with a diagnosis of osteomyelitis. He was discharged after one month with oral antibiotics and topical and oral ANGIPARS. After 2 months follow-up, complete osteogenesis was seen in serial radiographs.

Conclusion: In addition to healing the diabetic foot ulcer, ANGIPARS can also cause to reconstruct the degenerated bone and prevent debility due to limb amputation. Thus, the oral and topical application of ANGIPARS in the treatment of diabetic foot ulcer is recommended and more research is needed to reveal the benefits of ANGIPARS.