Background: Sublingual captopril was shown to be effective to control hypertensive urgencies however, there exist controversies regarding the true dosage. In this study, we have compared 2 dosage (12.5 and 25 mg) of sublingual captopril to find out which is more effective.
Materials and Methods: In a randomized clinical trial subjects with blood pressure of 180/110 mmHg who had no finding compatible with major organ damage were distributed in 2 groups (20 patients in each one) systolic and diastolic blood pressure were determined at minutes 5, 10, 20, 30, 45, 60, 90 and 120 following the drug administration. Data analysis was achieved using chi-square and ANOVA.
Results: There was no significant difference regarding the age, sex, previous history of hypertension, previous history of captopril intake, and systolic and diastolic blood pressure prior to the study. In the group receiving 12.5mg captopril, the mean diastolic and systolic blood pressure dropped from 121±3 and 210±4 mmHg to 97±4 and 163±6 mmHg, respectively, after 120 minutes. For the second these figures dropped form 123±2 and 202±3 to 96±1 and 165±4 mmHg, respectively (P<0.0001). At minutes 60 and 120, 80 and 75% of the first group (Receiving 12.5mg captopril) and 80 and 90% of the second group (Receiving 25mg captopril) had diastolic blood pressure of less than 110 mmHg, (NS). There was no side effect.
Conclusion: Captopril has shown similar therapeutic effect in dosage of 12.5mg and 25mg.