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:: Volume 18, Issue 3 (Bimonthly 2014) ::
Feyz 2014, 18(3): 247-252 Back to browse issues page
The association of 1661AG polymorphism for CTLA-4 gene in patients with systemic lupus erythematosus
Mahdieh Shojaa, Mahsa Amoli, Naemeh Javid, Fatemeh Shakeri, Mehrdad Aghaie *, Mostafa Qorbani, Shima Rokn-Sharifi, Zahra Mohammadi, Hajar Haghighi
Golestan University of Medical Sciences , mehrdad1390@gmail.com
Abstract:   (3903 Views)

Background: Cytotoxic lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activation. CTLA-4 gene polymorphism is related to genetic susceptibility to various autoimmune diseases, including systemic lupus erythematosus (SLE). This study aimed to evaluate the role of CTLA-4 polymorphism at positions-1661AG in patients with SLE.

Materials and Methods: This study was performed on 180 SLE patients referred to 5th Azar educational hospital (Gorgan, Iran, during 2010-2011) and 304 ethnically-and age-matched healthy controls. Polymerase chain reaction restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotype and allele frequencies of this polymorphism.

Results: No statistically significant difference was observed between the studied genotypic and allelic frequencies between the SLE patients and healthy controls. Moreover, no significant correlation was found between the different risk factors (e.g., age, ethnicity, history of the disease and the parents' relationship) and the different genotypes.

Conclusion: Results suggest that the -1661AG polymorphism in the promoter region of the CTLA-4 gene has no role in the genetic susceptibility to SLE.

Keywords: CTLA-4 antigen, Lupus polymorphism CTLA-4, Polymorphism, Promoter, 1661AG
Full-Text [PDF 213 kb]   (874 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2014/06/8 | Accepted: 2014/06/8 | Published: 2014/06/8
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Shojaa M, Amoli M, Javid N, Shakeri F, Aghaie M, Qorbani M, et al . The association of 1661AG polymorphism for CTLA-4 gene in patients with systemic lupus erythematosus. Feyz. 2014; 18 (3) :247-252
URL: http://feyz.kaums.ac.ir/article-1-2281-en.html

Volume 18, Issue 3 (Bimonthly 2014) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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