Background: Central beta-noradrenergic system plays an important role in the learning and memory processes. Dorsal hippocampus also has an overlapped distribution of beta-noradrenergic receptors. The aim of this study was to evaluate the possible role of the dorsal hippocampal beta-1 noradrenergic receptors in memory retrieval using a passive avoidance learning task.
Materials and Methods: This experimental study was performed on adult male Wistar rats (weight, 230±20gr). After anaesthetizing, the rats were cannulated into dorsal hippocampus using the stereotaxic surgery. After one week, passive avoidance memory was studied in two phases: training and testing with a 24h interval. The step-through latency to enter dark compartment and the time spent in this compartment was recorded for the evaluation of memory. All animals received drugs or saline, as intra- dorsal hippocampal microinjection, 30 min before testing.
Results: Pre-testing administration of dobutamine (1 μg/rat), a beta-1 noradrenergic receptor agonist, potentiated passive avoidance memory retrieval, while pre-testing injection of betaxolol (0.5μg/rat), a beta-1 noradrenergic receptor antagonist, inhibited passive avoidance memory retrieval. Also, the injection of ineffective and low doses of betaxolol (0.125 and 0.25 μg/rat) inhibited the effect of dobutamine on the memory retrieval.
Conclusion: It seems that beta-1 noradrenergic receptors of the dorsal hippocampus may mediate memory retrieval in a passive avoidance learning model.
Fathinia K, Khajehpour L, Moazedi A A, Bemani-Lirgeshasi S. Involvement of dorsal hippocampal beta-1 noradrenergic receptors in memory retrieval of rats. Feyz 2014; 17 (6) :582-589 URL: http://feyz.kaums.ac.ir/article-1-2111-en.html