[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 12, Issue 1 (Quarterly 2008) ::
Feyz 2008, 12(1): 76-80 Back to browse issues page
The prevalence of FXIII Val34Leu polymorphism in thrombotic patients referred to coagulation unit of Iranian Blood Transfusion Organization (IBTO)
Seyeyd Mahdi Sajjadi , Shahram Samie , Maryam Kheirandish , Zahra Ataiei , Mahnaz Kavari , Maryam Abdollahi , Samiramis Tootian , Mohammad Reza Tabatabaiei , Reza Meshkani
, shsamie@yahoo.com
Abstract:   (9623 Views)

Background: Coagulation factor XIII is a transglutaminase with a tetrameric structure which consists of two identical pre enzyme subunits (FXIIIA) and two carrier protein subunits (FXIIIB). FXIII Val34Leu polymorphism has a high prevalence in Caucasians. The prevalence of FXIII Val34Leu polymorphism in Iranian patients was investigated in this study by PCR-RFLP method.

Materials and Methods: In this descriptive study blood samples of 213 patients referred to the central laboratory of IBTO were assessed by DNA extraction and polymerase chain reaction (PCR). Then the genotypes of this polymorphism were identified by RFLP method in the presence of restricted enzyme. Data analyzed by SPSS 11.5 software and X2 Test.

Results: The prevalence of Val34Leu polymorphism was 24.4% (22.06% heterozygote and 2.34% homozygote and 13.07% of Leu allele frequency). No relationship was seen between the polymorphism and sex.

Conclusion : The high prevalence of FXIII Val34Leu polymorphism in Iranian thrombotic patients in comparison with reports from other Asian countries confirms the ethnic heterogenecity of this polymorphism which is not influenced by sex.
Keywords: FXIII, PCR-RFLP, Polymorphism, Thrombosis, Val34Leu
Full-Text [PDF 211 kb]   (1964 Downloads)    
Type of Study: Research | Subject: General
Received: 2008/10/22 | Revised: 2008/10/22 | Published: 2008/04/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sajjadi S M, Samie S, Kheirandish M, Ataiei Z, Kavari M, Abdollahi M, et al . The prevalence of FXIII Val34Leu polymorphism in thrombotic patients referred to coagulation unit of Iranian Blood Transfusion Organization (IBTO). Feyz 2008; 12 (1) :76-80
URL: http://feyz.kaums.ac.ir/article-1-21-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 12, Issue 1 (Quarterly 2008) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4645