Background: Bear in mind the prevalence of breast cancer and the importance of identifying its risk factors and also with respect to the controversies regarding the positive family history of breast cancer, the present study was carried out to determine the frequency of positive family history of breast cancer in 100 breast cancer sufferers in Kashan, during a 7-year period, 1372-79.

Materials and methods: For this descriptive study, all patients with breast cancer who had biopsies referred to pathology department of Kashan University were enrolled. Patients were interviewed and initial data gathered.

Results: 100 female patients were enrolled. The mean age of subjects was 51±14.3 years (24-82 years). The frequency of breast cancer did not obey a regular pattern during the studied period. Of these, 51% had left-side, 46% had right-side, and 3% had bilateral tumor. Frequency of positive family history of breast cancer was 8% in first degree relatives, 13% in second degree relatives and 21% in total. Invasive ductal carcinoma (IDC) was the most common pathologic findings (88%).

Conclusion: With respect to the high frequency of positive family history, better follow up, and more precise examination are highly recommended in subjects with positive family history of breast cancer.