:: Volume 17, Issue 4 (Bimonthly 2013) ::
Feyz 2013, 17(4): 366-372 Back to browse issues page
Relationship between serum levels of IL-4 and IgE with disease severity in allergic asthma
Mohammad Ali Saba, Hossein Akbari, Seyyedeh Masoomeh Banihashemian, Hoda Jazayeri, Sayyed Alireza Talaei, Sayyed Shahabadin Banihashemian *, Samira Ghaforian
Kashan University of Medical Sciences , shahab_banihashemian@yahoo.com
Abstract:   (6279 Views)

Background: IL-4 is an important mediator of inflammatory cytokine derived from T helper cells and mast cells which triggers IgE synthesis. IL-4 plays an important role in allergic immune response for its ability to prevent apoptosis of T lymphocytes. IL-4 also plays a role in lymphocytes cell differentiation, cytokines and IgE production. This study aimed to evaluate the relation between the serum levels of IL-4 and IgE with disease severity in patients with allergic asthma.

Materials and Methods: In this case-control study, 110 asthmatic patients referred to Asthma and Allergy Clinic in Kashan and 70 healthy controls were randomly selected. Blood sample (5 ml) was taken from all the patients and healthy subjects and the serum levels of IL-4 and IgE were measured using the standard laboratory kits and ELISA method, respectively.

Results: The IL-4 and IgE mean levels were not significantly associated with age and sex. The mean IgE level increased from moderate to severe with increasing asthma severity (P=0.847). Moreover, the IL-4 level in patients with severe asthma was higher than the other patients (P=0.002).

Conclusion: IL-4 level was increased with increasing asthma severity, but this was not the case for IgE.

Keywords: Asthma, Interleukin-4, Immunoglobulin E
Full-Text [PDF 232 kb]   (1585 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2013/08/14 | Accepted: 2013/09/4 | Published: 2013/09/4


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Volume 17, Issue 4 (Bimonthly 2013) Back to browse issues page