Background: Lifestyle modifications are required to promote the quality of physical and mental health performance in the middle-aged women. Therefore, this study aimed to determine the effect of performing a supportive health promotion program on lifestyle of the premenopause teachers.

Materials and Methods: In this quasi-experimental study, two case (50) and control (41) groups were selected by the convenience sampling. The supportive program for health promotion was performed at the three stages: assessment, supportive planning and evaluation. Data were collected using the demographic data and health promotion lifestyle profile II (HPLP II) questionnaires before and 45 days after the intervention in both groups.

Results: Findings showed that no significant difference was seen between the two groups in the mean numbers of the health-promoting behaviors before the intervention (P= 0.467), while a significant difference was seen after the intervention (P=0.001). Moreover, a significant difference was seen between the mean numbers of the health-promoting behaviors in the case group before and after the intervention (P=0.001).

Conclusion: According to the results of the study, implementing a supportive health promotion program has a positive effect on lifestyle of the teachers. Therefore, such programs should be applied as an effective method to promote lifestyle in the middle-aged women.