Background: Statins may be effective in reducing the risk of cerebral ischemia. This study aimed to examine the effect of Statins on the short-term prognosis of cerebral ischemia.

Materials and Methods: This cohort study was performed on 230 patients, whose cerebral ischemia had been confirmed by the neurologist. Eighty patients were treated with Statins at least three months before the onset of disease, and 150 patients had no history of Statin treatment. Demographic and background data and motor ability of the patients were evaluated based on the modified ranking scale (MRS). The patient's motor status on admission was compared to that of the discharge time. A case was considered as poor prognosis if the motor condition would not change or become worse and as better, if it would become better on discharge.

Results: Among 230 patients (mean age, 71.59 years), 103 cases were women (44.8%) and 127 men (55.2%). On admission, fifty-five (68.8%) patients in the Statin group and 26 (17.3%) in non-Statin group and on discharge, 70 patients (87.5%) in the Statin group and 43 (28.7%) in non-Statin group had better motor status (MRS<4, P<0.0001). Moreover, 67 patients (83.8%) in the Statin group and 43 (28.7%) in non-Statin group had a good prognosis (P<0.0001).

Conclusion: Short-term prognosis in the Statin group before the onset of disease is better than that in the non-Statin group.