[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 679-680 Back to browse issues page
The effect of Trientine and flaxseed oil on serum Copper and lipoproteins in diabetic rats
Esfandiar Heidarian , Elham Pournajaf , Ali Rezaei
Shahrekord University of Medical Sciences , heidarian46@yahoo.com
Abstract:   (7579 Views)

Background: Diabetes causes disorders in serum trace elements and lipoprotein metabolism. The aim of this study was to determine the effect of co-administration of trientine (Cu chelator agent) and flaxseed oil on serum copper and lipoproteins in diabetic rats.

Materials and Methods: Rats were divided into five groups. Diabetes was induced in 4 groups. Group I received Trientine plus flaxseed oil, group II the standard diet plus Trientine, Group III flaxseed oil and group IV was a diabetic group without treatment. Group V received the standard diet as a control group. After 2 months, the serum Cu2+, TG, Chol, and HDL-C were determined.

Results: In the Trientine plus flaxseed oil group, the serum TG and LDL significantly decreased (P<0.05) compared to the other groups. Also, the serum Chol in supplemented Trientine plus flaxseed oil group decreased (P<0.05) compared to the group which received the standard diet plus Trientine. HDL-C in group received standard diet plus Trientine significantly increased (P<0.05) compared to the other groups. In the group that received Trientine, the serum Cu2+ significantly decreased (P<0.05) compared to the other groups. Moreover, the serum Cu2+ in group received Trientine plus flaxseed oil significantly decreased (P<0.05) compared to the groups that received flaxseed oil and a diabetic group without treatment. In the flaxseed oil group, the serum Cu2+ significantly elevated (P<0.05) compared to the other groups, but this group showed no salient difference (P>0.05) compared to a diabetic group without treatment.

Conclusion: The usage of Cu2+ chelator such as Trientine may reduce the side effects of Cu2+ in diabetes. Co-administration of flaxseed oil plus Trientine significantly reduced the serum of Cu2+ and biochemical parameters such as TG, TC, LDL-C, and Chol in diabetes.

Keywords: Diabetes, Serum Cu, Flaxseed oil, Serum lipids, Trientine
Full-Text [PDF 122 kb]   (1271 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/03/3 | Published: 2013/03/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Heidarian E, Pournajaf E, Rezaei A. The effect of Trientine and flaxseed oil on serum Copper and lipoproteins in diabetic rats. Feyz 2013; 16 (7) :679-680
URL: http://feyz.kaums.ac.ir/article-1-1805-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4645