Background: Polycystic ovary syndrome (PCOS), as the most prevalent endocrine disorder in reproductive-aged women, is associated with reproductive and metabolic abnormalities. Despite the large literature on the role of dietary composition in control of the metabolic disease, there is so little research on the mineral nutritional status of PCOS women. Thus, this study aimed to determine the serum concentrations of Chromium (Cr), Zinc (Zn) and Magnesium (Mg) in PCOS women in comparison with the healthy controls.

Materials and Methods: This case-control study was carried out on 50 PCOS women and 50 healthy subjects within the age range of 20-45 years. Serum concentrations of Zn, Cr and Mg were estimated by a flame atomic absorption spectrophotometer.

Results: Subjects with PCOS had significantly lower serum concentrations of Zn, Cr and Mg as compared with the control group (P<0.05). In PCOS subjects, the serum glucose levels were negatively correlated with the serum concentrations of Zn (P<0.01), Cr (P<0.001) and Mg (P<0.02).

Conclusion: Concentrations of the Zn, Cr and Mg serum were significantly lower in PCOS women compared to the healthy controls. Moreover, the altered Zn, Cr and Mg levels were related to the glycemic status.