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:: Volume 16, Issue 5 (Bimonthly 2012) ::
Feyz 2012, 16(5): 414-419 Back to browse issues page
Comparing the effects of prednisolone and promethazine in the treatment of hyperemesis gravidarum: a double-blind, randomized clinical trial
Zahra Basirat, Shahnaz Barat *, Ali Akbar Moghadamnia
Babol University of Medical Sciences , shahnaz_barat200@yahoo.com
Abstract:   (5720 Views)

Background: Nausea and vomiting during pregnancy is one of the most frequent obstetric problems of unknown etiology and there is no definitive treatment for it. The purpose of this study was to compare the effects of prednisolone and promethazine in the treatment of hyperemesis gravidarum.

Materials and Methods: This double-blind clinical trial study was conducted on 70 pregnant women, with a singleton pregnancy at less than 16 weeks of gestation, with hyperemesis gravidarum. Women were randomly divided into two groups to receive either prednisolone (5mg) or promethazine (25mg) three times daily they received capsules with similar shapes but different codes. The dose of medication was tapered down after the first week and it was discontinued after two weeks. Finally, women were studied for relapse symptoms during the treatment and two weeks post-treatment.

Results: There was a significant difference in the improvement of symptoms between the two groups during the course of treatment and also two weeks post-treatment (P=0.001). Moreover, there was no significant difference between the two groups in the frequency of nausea and vomiting during the first 4 days, in the 14th day of the treatment and 2 weeks post-treatment (P=0.07).

Conclusion: Results show that both prednisolone and promethazine are effective to control hyperemesis gravidarum.

Keywords: Prednisolone, Promethazine, Hyperemesis gravidarum, Nausea and vomiting, Pregnancy
Full-Text [PDF 181 kb]   (3094 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2012/10/14 | Published: 2012/10/15
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Basirat Z, Barat S, Moghadamnia A A. Comparing the effects of prednisolone and promethazine in the treatment of hyperemesis gravidarum: a double-blind, randomized clinical trial . Feyz. 2012; 16 (5) :414-419
URL: http://feyz.kaums.ac.ir/article-1-1630-en.html


Volume 16, Issue 5 (Bimonthly 2012) Back to browse issues page
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