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:: Volume 9, Issue 1 (Quarterly 2005) ::
Feyz 2005, 9(1): 26-29 Back to browse issues page
Effect of Stress Resulting from Independent and Synergic Morphine Use on Serum Cortisol Level in Rat
Maryam Rad Ahmadi *, Masoud Amini, Mehrafarin Fesharaki, Mohammad Reza Sharifi
Abstract:   (6052 Views)

Background: In this study effects of stress resulted from using independent and co-administration morphine and carbohydrate on serum cortisol levels in rat were investigated to determine the possible causal link between morphine, carbohydrate and serum cortisol level.

Materials and Methods: This experimental study was performed on 24 male Wistar rats (200-250 gr) divided to 3 groups (n=8). Morphine dependency was induced by increasing doses of morphine through intraperitioneal (IP) injection. Animals were injected 10,20,30,40,50,60 mg/kg morphine sulfate on days 1,2,3,4,5,6 respectively and dose of 60 mg/kg was repeated for 20 extra days (Mo group). Another group of animals received the same dose of morphine plus l gr/kg glucose per day through intraperitoneal (IP) injection (Mo+Glu group). Duration of experiment was 26 days.

Results: Significant increase in serum cortisol level was observed after long-term use of both morphine and co-administration of morphine and carbohydrate. However, this increase was higher in Mo+Glu group than morphine group. (16.57% vs. 11.55%, P<0.05)

Conclusion: long-term use of morphine, with or without carbohydrate, may increase serum cortisol level

Keywords: Morphine, Carbohydrate, Cortisol
Full-Text [PDF 194 kb]   (1462 Downloads)    
Type of Study: Research | Subject: General
Received: 2008/11/1 | Published: 2005/04/15
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Rad Ahmadi M, Amini M, Fesharaki M, Sharifi M R. Effect of Stress Resulting from Independent and Synergic Morphine Use on Serum Cortisol Level in Rat. Feyz. 2005; 9 (1) :26-29
URL: http://feyz.kaums.ac.ir/article-1-158-en.html

Volume 9, Issue 1 (Quarterly 2005) Back to browse issues page
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