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:: Volume 16, Issue 4 (Bimonthly 2012) ::
Feyz 2012, 16(4): 346-352 Back to browse issues page
Antibiotic resistance pattern of Vibrio cholerae strains isolated from the stool of cholerae patients in Kashan during 1998-2009
Hasan Afzali, Ahmad Khorshidi *, Sayyed Alireza Moravveji, Azadeh Baghbani
Kashan University of Medical Sciences , khorshidi_a@kaums.ac.ir
Abstract:   (6239 Views)

Background: Cholera is an acute diarrhoeal disease that can cause severe dehydration and death within the hours of its onset. Considering the importance of the disease, this study was carried out to assess the antibiotic resistance pattern of Vibrio cholerae (V. cholerae) strains isolated from the stool of cholerae patients in Kashan during 1998-2009.

Materials and Methods: This cross-sectional study was carried out on stool specimens obtained from acute diarrhea cases referred to health care centers in Kashan. The samples were identified according to the guidelines established by the National Committee for Clinical Laboratory Standards (NCCLS) and then the biotype and serotype of V. cholerae isolates were identified using the enzymatic method. Finally, antibiotic sensitivity testing was performed using the Kirby-Bauer disk diffusion method.

Results: Resistance to all antibiotics except erythromycin was seen in all isolates of V. cholerae (58 isolates). The highest antibiotic resistance rate was seen for ampicillin (31%) and the lowest ones for doxycycline, ciprofloxacin and tetracycline (7.1%), respectively. Moreover, among different V. cholerae serotypes, the lowest and highest levels of antibiotic resistance were seen for Inaba and Ogawa serotypes, respectively. There was no significant difference in resistance pattern between the different age and gender groups.

Conclusion: According to the results of this study, an increased antibiotic resistance in V. cholerae has been observed which can result in the emergence of multidrug resistance and therapeutic complications.

Keywords: Vibrio cholerae, Cholerae, Antibiotic resistance
Full-Text [PDF 237 kb]   (1180 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2012/07/25
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Afzali H, Khorshidi A, Moravveji S A, Baghbani A. Antibiotic resistance pattern of Vibrio cholerae strains isolated from the stool of cholerae patients in Kashan during 1998-2009. Feyz. 2012; 16 (4) :346-352
URL: http://feyz.kaums.ac.ir/article-1-1555-en.html


Volume 16, Issue 4 (Bimonthly 2012) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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