:: Volume 16, Issue 4 (Bimonthly 2012) ::
Feyz 2012, 16(4): 288-296 Back to browse issues page
Influence of dorsal hippocampal GABA receptors on state-dependent learning induced by CB1 cannabinoid receptors agonist in mice
Kobra Jafari, Shahrbano Oryan, Bahareh Pakpour, Majid Navaeian, Morteza Piri *
Islamic Azad University, Ardabil Branch, , biopiri@iauardabil.ac.ir
Abstract:   (6958 Views)

Background: Cannabinoids exert widespread effects on cognitive functions. An overlapped distribution of GABA receptors and cannabinoid receptors has been reported in some brain structures (e.g. dorsal hippocampus). Thus, the present study was undertaken to examine the possible role of the dorsal hippocampus GABAA receptors on ACPA induced amnesia and ACPA state-dependent memory.

Materials and Methods: This experimental study was conducted on 250 adult male NMRI mice. Muscimol and ACPA were used as agonists of GABAA and the cannabinoid CB1 receptors, respectively. Mice were anaesthetized and cannulae were implanted bilaterally into the CA1 regions of the dorsal hippocampus. Seven days after post-surgery recovery, the behavioral testing was performed using an inhibitory avoidance task and the step-down latency of the animals was used to assess memory retention.

Results: Post-training administration of ACPA (3ng/mouse) impaired the memory retrieval. The memory impairment induced by ACPA was fully reversed by pre-test administration of ACPA or muscimol.

Conclusion: The results suggest that the GABAA receptors of the dorsal hippocampal may play an important role in ACPA-induced amnesia and ACPA state-dependent memory.

Keywords: ACPA, Muscimol, State-dependent memory, Inhibitory avoidance learning, Mouse
Full-Text [PDF 376 kb]   (1648 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2012/07/25 | Published: 2012/07/15


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Volume 16, Issue 4 (Bimonthly 2012) Back to browse issues page