[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 16, Issue 4 (Bimonthly 2012) ::
Feyz 2012, 16(4): 330-336 Back to browse issues page
Evaluation of patients with common variable immunodeficiency and detection of IL-2 as a cell-mediated immune index
Marzieh Heidarzadeh-Arani , Anna Isaeian , Ahmad Piroozmand
Kashan University of Medical Sciences , apiroozmand@kaums.ac.ir
Abstract:   (8951 Views)

Background: Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiencies characterized by impaired antibody responses, defect in T-cell proliferation and secretion of cytokines, especially IL-2. This study aimed to evaluate the function of cellular immune system in CVID patients based on Il-2 level, as a cell-mediated immune index, as well as the clinical and paraclinical evaluation of such patients.

Materials and Methods: This case-control study was conducted on 20 CVID and 10 healthy participants referred to the Immunology and Allergy Department at Children Medical Center in Kashan. The clinical and paraclinical findings of the patients were collected using the questionnaire. The peripheral blood mononuclear cells were cultured with PHA in both groups and then the supernatants were collected for quantification of IL-2 secretion using the ELISA method.

Results: CVID was seen in 85% of the cases hospitalized with infection. The most common infection was respiratory tract infection the opportunistic infections and autoimmunity were seen in 5-10% and 40% of the cases, respectively. Delayed-type hypersensitivity response was negative in 65% of the patients. Moreover, IL-2 level was zero in15 patients and lower than that of the control group in 5 patients (P<0.05).

Conclusion: All patients showed deficiency in T-cell function with decreased IL-2 production. The manifestations of this deficiency are a high incidence of autoimmunity, granulomatosis, bronchiectasis and recurrent infections in the patients in spite of monthly IVIG injections.

Keywords: Common Variable Immunodeficiencies, IL-2, Cell-mediated immune index
Full-Text [PDF 160 kb]   (3255 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2012/07/25 | Revised: 2012/08/7 | Published: 2012/07/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Heidarzadeh-Arani M, Isaeian A, Piroozmand A. Evaluation of patients with common variable immunodeficiency and detection of IL-2 as a cell-mediated immune index . Feyz 2012; 16 (4) :330-336
URL: http://feyz.kaums.ac.ir/article-1-1547-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 16, Issue 4 (Bimonthly 2012) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4645