[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 16, Issue 2 (Bimonthly 2012) ::
Feyz 2012, 16(2): 102-111 Back to browse issues page
Effect of exercise and chronic administration of nandrolone decanoate on expression of rat heart sarcolemmal ATP- sensitive potassium channels
Gholam Reza Bayat, Sohrab Hajizadeh *, Mohammad Javan, Fatemeh Safari, Mahdi Goodarzvand, Saeed Shokri, Khalil Pourkhalili, Firozeh Alavian
Tarbiat Modares University , Hajizads@modares.ac.ir
Abstract:   (5399 Views)

Background: The anabolic androgenic steroids are known to stimulate muscle protein synthesis and hypertrophy. Cardiomyocytes have two types of ATP-sensitive potassium channels in sarcolemma (sarcKATP) and in mitochondria (mitKATP). Activation of the sarcKATP channels has been proposed to protect against ischemia-reperfusion injury. This study aimed to investigate the effect of nandrolone decanoate on the expression of sarcKATP channels in the presence and absence of exercise in rat heart.

Materials and Methods: In this experimental study, 40 adult male rats were divided into five groups: control, vehicle, ND, exercise and exercise-ND group. Rats in the exercise group were submitted to a running program on a treadmill, 5 days a week for 10 weeks. In addition, rats in the ND and exercise-ND groups received a weekly intramuscular injection of ND (10 mg/kg) for 10 weeks. Expression of the KATP channel subunits (Kir6.2 and SUR2) was determined using the Western blotting method.

Results: ND administration had no effect on the expression of sarcKATP channel subunits in the sedentary group, while the chronic exercise significantly increased the expression of KATP channel subunits (P=0.01). Moreover, the ND administration significantly decreased the Kir6.2 (P=0.001) and SUR2 (P=0.05) subunits in the exercised animals.

Conclusion: Chronic exercise and ND increases and decreases the expression of sarcKATP channels, respectively. The ND-induced expression decrement of channels is probably one of the mechanisms involved in the impairment of exercise-induced cardioprotection in rat heart.

Keywords: Exercise, Nandrolone decanoate, KATP sensitive Potassium channels, Rat heart
Full-Text [PDF 308 kb]   (1468 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2012/02/28
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bayat G R, Hajizadeh S, Javan M, Safari F, Goodarzvand M, Shokri S, et al . Effect of exercise and chronic administration of nandrolone decanoate on expression of rat heart sarcolemmal ATP- sensitive potassium channels . Feyz. 2012; 16 (2) :102-111
URL: http://feyz.kaums.ac.ir/article-1-1422-en.html


Volume 16, Issue 2 (Bimonthly 2012) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 3937