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:: Volume 12, Issue 1 (Quarterly 2008) ::
Feyz 2008, 12(1): 21-25 Back to browse issues page
Evaluation of interferon producing cells count in human immunodeficiency virus and hepatitis G co-infected patients
Mostafa Haji-Molla-Hoseini *, Ali akbar Pourfathollah, Soheila Soheili, Shahram Samiee, Reza Mashkani
, Hajimolahoseini@yahoo.com
Abstract:   (8192 Views)

Background: Interferon producing cells have an important role in controlling HIV. The interferon producing cell count was evaluated in order to study the possibility of immune modulating qualification of HGV co-infection in HIV patients’ safety.

Materials and Methods: This descriptive study was performed on 83 HIV positive patients with CD4+ cell count >400 to evaluate the interferon producing cell count. These 83 patients were categorized in 4 groups based on their current infection status. Patients infected with HCV and HGV (HGV+/HCV+), patients infected with HGV but not with HCV (HGV-C+/HCV-), patients infected with HCV but not with HGV (HGV-/HCV+) and patients not infected by HGV and HCV (HGV-/HCV-). Interferon producing cell analysis was performed by flow cytometric method and the presence of -HGV RNA by using RT-PCR and PCR-Elisa.

Results: Interferon producing cell count in HGV co-infected individuals revealed a wider range of numbers however there was no significant difference in the interferon producing cells count between HIV infected patients with and without HGV co-infection.

Conclusion: HGV/HCV co-infection doesn't have an effective role on increasing of production or rotation of interferon producing cell in HIV infected patients with relatively intact immune system.

Keywords: Human immunodeficiency virus, Interferon producing cells, Hepatitis G and co-infection
Full-Text [PDF 220 kb]   (1784 Downloads)    
Type of Study: Research | Subject: General
Received: 2008/10/22
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Haji-Molla-Hoseini M, Pourfathollah A A, Soheili S, Samiee S, Mashkani R. Evaluation of interferon producing cells count in human immunodeficiency virus and hepatitis G co-infected patients. Feyz. 2008; 12 (1) :21-25
URL: http://feyz.kaums.ac.ir/article-1-13-en.html

Volume 12, Issue 1 (Quarterly 2008) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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