Background: Concerning the adverse effects of bacterial infections in the lesions due to cutaneous leishmaniasis sush as: diagnosis, treatment and increased cost, duration of treatment and progress of healing in skin lesions, this study was carried out in cutaneus leishmaniasis patients refered to the central laboratory in Kashan, Iran, 2003.

Materials and Methods: A descriptive study was condacted on 117 of 164 patients with skin lesions in the central laboratory of Kashan, Iran, 2003. Speciemens were collected and inoculated in blood agar and cosin-methylen blue agars chioglycolate. Identification of the tsclates was determined baccording to a standard method and antimicrobial susceptibility of the isolated was done by disk diffusion method. The results were analyzed statistically

Results: There was bacterial infection in 32 acses (19.5%). Staphylococcus aureus was the most common pathogen and showed the most rate of antibiotic sensitivity to ceftriaxon and erythromycin.

Conclusion: To treat these lesions by antibiotic, diagnosing the secondary bacterial contamination due to cutaneous leishmaniasis is necessary.