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:: Volume 28, Issue 2 (Bimonthly 2024) ::
Feyz Med Sci J 2024, 28(2): 174-182 Back to browse issues page
The effect of high intensity interval training and thyme supplementation on serum levels of omentin 1 and fibroblast growth factor 21 in sedentary young girls
Zahra Mohseni , Bahram Abedi * , Yaser Kazemzadeh
Department of Sports Physiology, Faculty of Humanities, North Tehran Branch, Islamic Azad University, Tehran, Iran , abedi_bahram2000@yahoo.com
Abstract:   (454 Views)
Background and Aim: Various factors in the body, such as omentin-1 (an adipokine of fat tissue) and FGF21 (an endocrine hormone with anti-inflammatory properties), decrease after periods of inactivity. This study aimed to investigate the effects of high-intensity interval training (HIIT) and thyme supplementation on the serum levels of omentin-1 and FGF-21 in sedentary young girls.
Methods: In this clinical trial, 48 young girls were randomly assigned to four groups (n=12 each): HIIT training, thyme supplementation, HIIT + thyme, and control. Serum samples were collected at two time points: pre-test and post-test. Serum levels of omentin-1 and FGF21 were analyzed using specific ELISA kits.
Results: The results showed that there was no significant difference in serum omentin-1 levels before (P=0.505) and after (P=0.542) the test in all four groups. However, post-test FGF-21 levels varied significantly among the groups (P=0.014). Post-test results indicated that FGF-21 levels were significantly higher in the HIIT + Thyme group (P=0.019; effect size=0.465), HIIT group (P=0.049; effect size=0.406), and thyme group (P=0.037; effect size=0.424) compared to the control group. Furthermore, a significant increase in the FGF-21 levels was observed in the thyme (P=0.001), HIIT (P=0.002), and HIIT + thyme (P=0.003) groups after the interventions.
Conclusion: The study suggests that the increase in FGF-21 is a beneficial outcome of HIIT exercises with or without thyme supplementation. Combining HIIT exercises with thyme supplements may lead to a greater increase in FGF-21 levels. However, further research is required to confirm these findings.
Keywords: High-intensity interval training (HIIT), Thyme, FGF-21, Omentin1, Sedentary
Full-Text [PDF 461 kb]   (274 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2024/03/22 | Revised: 2024/08/18 | Accepted: 2024/05/20 | Published: 2024/06/2
References
1. Burini RC, Anderson E, Durstine JL, Carson JA. Inflammation, physical activity, and chronic disease: An evolutionary perspective. Sports Med Health Sci 2020; 2(1): 1-6. doi:10.1016/j.smhs.2020.03.004 PMid:35783338 PMCid:PMC9219305
2. Pechtl SM, Kim LP, Jacobsen KH. Physical inactivity and sedentariness: Languorous behavior among adolescents in 80 countries. J Adolesc Health 2022; 70(6): 950-60. doi:10.1016/j.jadohealth.2021.12.017 PMid:35177343
3. Paroi S, Hasanat MA, Roy BK. Study on the sedentary lifestyle of adolescents in Khulna city. Mediscope 2022;9(2):68-74 doi:10.3329/mediscope.v9i2.61707
4. Fasihi Ramandi E, Khaledi N. High intensity interval training induced changes in the hepatic FGF-21 gene expression and serum TNF-α in diabetic male rats. Res in Sports Med Tech. 2020;18(19):57-68.
5. Wang N, Zhao Tt, Li Sm, Sun X, Li Zc, Li Yh, et al. Fibroblast growth factor 21 exerts its anti‐inflammatory effects on multiple cell types of adipose tissue in obesity. Obesity (Silver Spring) 2019;27(3): 399-408. doi:10.1002/oby.22376 PMid:30703283
6. Liu M, Cao H, Hou Y, Sun G, Li D, Wang W. Liver plays a major role in FGF-21 mediated glucose homeostasis. Cell Physiol Biochem 2018;45(4):1423-33. doi:10.1159/000487568 PMid:29462809
7. Vecchiatto B, de Castro TL, Muller CR, Azevedo-Martins AK, Evangelista FS. Physical exercise-induced FGF-21 to fight obesity: An update review. Obesities 2022;2(4):372-9. doi:10.3390/obesities2040031
8. Tofighi A, Alizadeh R, Tolouei Azar J. The effect of eight weeks high intensity interval training (hiit) on serum amounts of fgf21 and irisin in sedentary obese women. Studies in Med Sci 2017;28(7):453-66. http://umj.umsu.ac.ir/article-1-4064-en.html
9. Castro CAd, Silva KAd, Rocha MC, Sene-Fiorese M, Nonaka KO, Malavazi I, et al. Exercise and omentin: their role in the crosstalk between muscle and adipose tissues in type 2 diabetes mellitus rat models. Front physiol 2019; 9: 1881. doi:10.3389/fphys.2018.01881 PMid:30666216 PMCid:PMC6330355
10. Sun X, Li T, Tian Y, Ren S, Li L, Li P. Omentin as an Independent Predictor of Metabolic Syndrome and Obesity Among Adolescents in Northeast China. Diabetes, Metab Syndr Obes: Targets and Therapy 2022:3913-22. doi:10.2147/DMSO.S388620 PMid:36545293 PMCid:PMC9762766
11. Zabetian-Targhi F, Mirzaei K, Keshavarz SA, Hossein-Nezhad A. Modulatory role of omentin-1 in inflammation: cytokines and dietary intake. J Am Coll Nutr 2016; 35 (8): 670-678. doi:10.1080/07315724.2015.1126207 PMid:27331575
12. Tanimura Y, Aoi W, Takanami Y, Kawai Y, Mizushima K, Naito Y, et al. Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation. Physiol rep 2016;4(12):e12828. doi:10.14814/phy2.12828
13. Gharakhanlou BJ, Bonab SB. The effect of 12 weeks of training in water on serum levels of SIRT1 and FGF-21, glycemic index, and lipid profile in patients with type 2 diabetes. Int J Diabetes in Developing Countries 2022:1-8. doi:10.1007/s13410-021-01032-5
14. Kong Z, Sun S, Liu M, Shi Q. Short-term high-intensity interval training on body composition and blood glucose in overweight and obese young women. J diabetes res 2016; 2016. doi:10.1155/2016/4073618 PMid:27774458 PMCid:PMC5059579
15. Garneau L, Parsons SA, Smith SR, Mulvihill EE, Sparks LM, Aguer C. Plasma myokine concentrations after acute exercise in non-obese and obese sedentary women. Front physiol 2020; 11: 18. doi:10.3389/fphys.2020.00018 PMid:32132925 PMCid:PMC7040180
16. Huang C-J, Slusher AL, Whitehurst M, Wells M, Maharaj A, Shibata Y. The impact of acute aerobic exercise on chitinase 3-like protein 1 and intelectin-1 expression in obesity. Exp Biol Med (Maywood) 2016; 241(2): 216-21. doi:10.1177/1535370215602785 PMid:26316585 PMCid:PMC4935391
17. Faramarzi M, Banitalebi E, Nori S, Farzin S, Taghavian Z. Effects of rhythmic aerobic exercise plus core stability training on serum omentin, chemerin and vaspin levels and insulin resistance of overweight women. J Sports Med Phys Fitness 2015;56(4):476-482.
18. Türk Y, Theel W, Kasteleyn M, Franssen F, Hiemstra P, Rudolphus A, et al. High intensity training in obesity: a Meta‐analysis. Obes Sci Pract 2017;3(3):258-71. doi:10.1002/osp4.109 PMid:29071102 PMCid:PMC5598019
19. Boutcher SH. High-intensity intermittent exercise and fat loss. J Obes 2011;2011. doi:10.1155/2011/868305 PMid:21113312 PMCid:PMC2991639
20. Hammoudi Halat D, Krayem M, Khaled S, Younes S. A focused insight into thyme: Biological, chemical, and therapeutic properties of an indigenous Mediterranean herb. Nutrients 2022; 14(10):2104. doi:10.3390/nu14102104 PMid:35631245 PMCid:PMC9147557
21. Eskandar Pour F, Tofighi A, Tolouei Azar J. Effects of eight-weeks of circuit resistance training with Thyme supplementation on serum FGF-21 in overweight menopausal women. J Appl Health Stud Sport Physiol 2018;5(2):20-7.
22. Jackson AS, Pollock ML. Practical assessment of body composition. Phys Sportsmed 1985; 13(5):76-90. doi:10.1080/00913847.1985.11708790 PMid:27463295
23. Jokar M, Sherafati Moghadam M, Daryanoosh F. The effect of a period of high-intensity interval training on the content of AMPK and PGC-1α proteins in the heart muscle tissue of rats with type 2 diabetes. Daneshvar Med 2021;29(1):23-34.
24. Khani M, Zolfi HR, Niknam Z. The effect of two-week high intensit interval training (HIIT) with Thyme supplementation on lipid profile, oxidative stress, body composition, and aerobic capacity of the obese and overweight women. J Appl Health Stud Sport Physiol 2023.
25. Group JJW. Guidelines for Rehabilitation in Patients with Cardiovascular Disease (JCS 2012)-Digest Version-. Circ J 2014; 78(8):2022-93. doi:10.1253/circj.CJ-66-0094 PMid:25047729
26. Liu Y, Dong G, Zhao X, Huang Z, Li P, Zhang H. Post-exercise effects and long-term training adaptations of hormone sensitive lipase lipolysis induced by high-intensity interval training in adipose tissue of mice. Front Physiol 2020;11:535722. doi:10.3389/fphys.2020.535722 PMid:33324231 PMCid:PMC7723847
27. Zhan J, Ling R, Guanghua W, Rongping W. Effects of high-intensity interval exercise on obesity. Front Sport Research 2022;4(5). doi:10.25236/FSR.2022.040510
28. Rizwan B. Therapeutic potential of Thymus vulgaris: A Review. doi:10.31219/osf.io/3fzvt
29. Keshavarzi E, Shakerian S. Effect of HIIT Exercises with Thyme Supplement on Plasma Lipoproteins and Liver Enzymes of Men with Fatty Liver: A Semi-experimental Study. Navid No 2020; 23(75):51-61.
30. Chau MD, Gao J, Yang Q, Wu Z, Gromada J. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway. Proc Natl Acad Sci U S A 2010; 107 (28): 12553-8. doi:10.1073/pnas.1006962107 PMid:20616029 PMCid:PMC2906565
31. Lee JS, Yoon ES, Jung SY, Yim KT, Kim DY. Effect of high-intensity circuit training on obesity indices, physical fitness, and browning factors in inactive female college students. J Exerc Rehabil 2021;17(3):207. doi:10.12965/jer.2142260.130 PMid:34285899 PMCid:PMC8257432
32. Taniguchi H, Tanisawa K, Sun X, Kubo T, Higuchi M. Endurance exercise reduces hepatic fat content and serum fibroblast growth factor 21 levels in elderly men. J Clin Endocrinol Metab 2016; 101(1): 191-8. doi:10.1210/jc.2015-3308 PMid:26562755
33. Mohammadi A, Gholamhoseinian A, Fallah H. Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats. Iran J Basic Med Sci 2014; 17(4):263. doi: 10.22038/IJBMS.2014.2584 PMid: 24904719 PMCid: PMC4046234
34. Makiel K, Suder A, Targosz A, Maciejczyk M, Kozioł-Kozakowska A, Haim A. Impact of two types of exercise interventions on leptin and omentin concentrations and indicators of lipid and carbohydrate metabolism in males with metabolic syndrome. J Clin Med 2023;12(8):2822. doi:10.3390/jcm12082822 PMid:37109160 PMCid:PMC10144374
35. Wilms B, Ernst B, Gerig R, Schultes B. Plasma omentin-1 levels are related to exercise performance in obese women and increase upon aerobic endurance training. Exp Clin Endocrinol Diabetes 2015;123(03):187-92 doi:10.1055/s-0034-1398504 PMid:25789872
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Mohseni Z, Abedi B, Kazemzadeh Y. The effect of high intensity interval training and thyme supplementation on serum levels of omentin 1 and fibroblast growth factor 21 in sedentary young girls. Feyz Med Sci J 2024; 28 (2) :174-182
URL: http://feyz.kaums.ac.ir/article-1-5148-en.html


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Volume 28, Issue 2 (Bimonthly 2024) Back to browse issues page
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