[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 21, Issue 6 (Bimonthly 2017) ::
Feyz 2017, 21(6): 517-524 Back to browse issues page
The effect of hydro-alcoholic extract of Salvia officinalis L. on the electrolytes and serum proteins in adult diabetic male rat
Maryam Mirchenari , Farnaz Tavakoli
Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, I. R. Iran. , maryammir900@gmail.com
Abstract:   (3394 Views)
Background: Diabetes is the result of functional impairment of insulin secretion. The aim of this study was to examine the effect of the Salvia officinalis (SO) extract on serum levels of albumin, total protein and serum sodium and potassium electrolytes.
Materials and Methods: In this experimental study, 50 adult male Wistar rats were divided into 5 groups of 10. The control group received food and water, the diabetic group received 60 mg/kg streptozotocin, the SO-treated control group received 400 mg/kg of SO daily, and the SO-treated diabetic groups received 200 and 400 mg/kg of SO daily. Injections were performed intraperitoneally. After 21 days, the blood sample was taken from the heart to measure the factors.
Results: The serum concentration of potassium in the diabetic group showed a significant increase compared to the control group and showed a significant decrease in the treated diabetic group compared to the diabetic group. The serum concentration of sodium in the diabetic group was significantly lower than the control group. Also, the serum concentrations of albumin and total proteins in the diabetic group significantly decreased compared to the control group and these concentrations significantly increased in the treated diabetic groups compared to the diabetic group. Moreover, the serum levels of albumin and total proteins in the treated control group significantly increased compared to the control group (P≤0.05).
Conclusion: The antioxidant compounds of the SO extract can increase the serum concentrations of total protein, albumin, potassium and sodium and have been proven effective in reducing complications of diabetes.
Keywords: Diabetes, Salvia officinalis L., Albumin, Total protein, Serum electrolytes
Full-Text [PDF 273 kb]   (1449 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/01/9 | Revised: 2018/01/10 | Accepted: 2017/11/12 | Published: 2018/01/7
References
1. Hussain A, Claussen B, Ramachandran A, Williams R. Prevention of type 2 diabetes: areview. Diabetes Res Clin Pract 2007; 76(3): 317-26.
2. Leeds JS, Forman EM, Morley S, Scott AR, Tesfaye S, Sanders DS. Abnormal liver function tests in patients with Type 1 diabetes mellitus: prevalence, clinical correlations and underlying pathologies. Diabet Med 2009; 26(12): 1235-41.
3. Banerjee SK, Dinda AK, Manchanda SC, Maulik SK. Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury. BMC Pharmacol 2002; 2(16): 1471-2210.
4. Grzegorczyk I, Matkowski A, Wysokinska H. Antioxidant activity of extracts from in vitro cultures of SalviaOfficinalis L. Food Chem 2007; 104 (2): 536-41.
5. Glisic SB, Ristic M, Skala DU. The combined extraction of sage (Salvia officinalis L.): ultrasound followed by supercritical CO2 extraction. Ultrason Sonochem 2011; 18(1): 318-26.
6. Generalić I, Skroza D, Ljubenkov I, Katalinić A, BurčulF, Katalinić V, Influence of the phenophase on the phenolic profile and antioxidant properties of Dalmatian sage. Food Chem 2011; 127(2): 427-33.
7. Salkovic-Petrisic M, Amyloid cascade hypothesis: is it true for sporadic Alzheimer's diseases. Period Biol 2008: 110(1); 17-25.
8. Capek P, Machová E, Turjan J. Scavenging and antioxidant activities of immunomodulating polysaccharides isolated from Salvia officinalis L. Int J Biol Macromol 2009; 44(1): 75-80.
9. Lima CF, Carvalho F, Fernandes E, Bastos ML, Santos-Gomes PC, Fernandes-Ferreira M, et al. Evaluation oftoxic/protective effects of the essential oil of Salvia Officinalis on freshly isolated rat hepatocytes. Toxicol In Vitro 2004; 18(4): 457-65.
10. Wang M, Shao Y, Li J, Zhu N, Rangarajan M, LaVoie EJ, et al. Antioxidative phenolic glycosides from sage (Salvia officinalis). J Nat Prod 1999; 62(3): 454-6.
11. Arabi S, Arshami J, Haghparast AR. Effects of Salvia Officinalis L. Extract on Biochemical Blood Parameters in Male Rats. ZUMSJ 2014, 22(94): 34-43.
12. Madar Z, Abel R, Samish S, Arad J. Glucose lowering effect offenugreek non- insulin dependent diabetics. Eur J Clin Nutr 1988; 42(1): 51-54.
13. Richelle M, Enslen M, Hager C, Groux M, Tavazzi I, GodinJP, et al. Both free and esterified plant sterols reduce cholesterol absorption and the bioavailability of beta–carotene and alpha- tocopherol in normocholesterolemic human. Am J Clin Nutr 2004; 80(1): 171-7.
14. Mirchenari M, Mokhtari M, Shariati M. The Effect of Hydroalcoholic Extract of Salvia Officinalis on Gonadotropin, and Sex Steroids in Adult Diabetic Male Rat. JSSU 2016; 23(10): 1018-27.
15. Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: a review. Internationale Pharmaceutica Sciencia 2011; 1(1): 98-106.
16. Eidi M, Eidi A, Bahar M, Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats. Nutrition 2006; 22(3): 321-6
17. Zare T, Mokhtari M, Mohammadi J. The effect of Hydroalcoholic extracts of prangos ferulacea on blood factors of kidney and liver functions in diabetic male wistar rats. J Fasa Univ Med Sci 2012; 2(3): 174-80. [in Persian]
18. Smith JM, Paulson DJ, Solar SM. Na+ /K+ -ATPase activity in vascular smooth muscle from streptozotozin diabetic rat. Cardiovasc Res 1997; 34(1): 137–44.
19. Al-said MS, Abdelsattar EA, Khalifa SI, EI-Feraly FS. Isolationand identification of an anti- inflammatory principle from Capparis spinosa. Pharmazie 1988; 43(9): 640-1.
20. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997; 46(1): 3–10.
21. Oyedemi SO, Bradly G, Afolayan AJ. Beneficial effect of aqueous stem bark extract of strychnos henningsii Gilg in Streptozotocin–nicotinamid induced type 1 diabetic Wistar rats. Int J Pharm 2011; 7(7): 773-81.
22. Mauer SM, Steffes MW, Brown DM. The kidney in diabetes. Am J Med 1981; 70(3): 603-12.
23. Almdal TP, Vilstrup H. Strict insulin therapy normalises organ nitrogen contents and the capacity of urea nitrogen synthesis in experimental diabetes in rats. Diabetologia 1988; 31(2): 114-8.
24. Tuvemo T, Ewald U, Kobboh M, Proos LA. Serum magnesium and protein concentrations during the first five years of insulin dependent diabetes in children. Acta Paediatrica 1997; 86(418): 7-10.
25. JamshidzadehA, Niknahad H. Hepato‌pro‌tective activity of Berberis integerrima Bge extract in rats treated with CCl4: In vitro and in vivo studies. Toxicol Lett 2006; 164: 310.
26. Pyo YH, Lee TC, Logendra L, Rosen RT. Antioxidant activity and phenolic compounds of Swiss chard (Beta vulgaris subspecies cycla) extracts. Food Chem 2004; 85(1): 19-26.
27. Mohammadi J, Naik PR. Evaluation of hypoglycemic effect of Morus alba in an animal model. Indian J Pharmacol 2008; 40(1): 15-8.
28. Soltani band Kh, Kafash Farkhad N, Farokhi F, Togmechi A. Effects of hydro-alcoholic extract of Prangos ferulacea (L.) Lindle on histopathology of pancreas and diabetes treatment in STZ- induced diabetic. JAJP 2012; 2(1): 31-8.
29. El-Ghany MA, Nagib RM, Mamdouh SM anti-Diabetic effect of some herbs and fruit against streptozotocin induced diabetic rats. GlobVet 2014; 12: 541-9.
30. Rashki Kemmak M, Gol A, Dabiri SH. Preventive effects of Garlic juice on renal damages induced by diabetes mellitus in rats. Iran J Endocrinol Metab 2009; 11(3): 331-40.
31. Thomson M, Al-Amin ZM, Al-Qattan KK, Shaban LH, Muslim A. Anti-diabetic and Hypolipidemic properties of garlic (Allium sativum) in streptozotocin-induced diabetic rats. Int J Diabetes & Metabolism 2007: 108-15.
32. Zafar M, Naqvi SN, Ahmed M, Kaimkhani ZA. Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats. Int J Morphol 2009; 27(3): 783-90.
33. Mokhtary M, Sharifi E, Shahamir-Tabatabaee M. The effect of carob extract on liver function test in diabetic male rat. J Shahrekord Univ Med Sci 2013; 15(3): 40-7. [in Persian]
34. Morsy MD, Hassan WN, Zalat SI. Improvement of renal oxidative stress markers after ozone administration in diabetic nephropathy in rats. Diabetol Metab Syndr 2010; 2(1): 29.
35. Wiseman MY, Saunder AJ, Keen H, Viberti G Effectof blood glucose control on increased glomerular filtration rate and kidney size in insulin–dependent diabetes. N Engl J Med 1985; 312: 617-21.
36. Moore RD. Effects of insulin upon ion transport. Biochem Biophys Acta 1983; 737(1): 1-49.
37. Velasco Plaza A, G-Granda T, Cachero MT. Circadian rhythms of food and water intake and urine excretion in diabetic rats. Physiol Behav 1999; 54(4): 665-70.
38. Smith JM, Paulson DJ, Solar SM. Na+/K+-ATPase activity in vascular smooth muscle from streptozotozin diabetic rat. Cardiovasc Res1997; 34(4); 137–44.
39. Greene DA, Lattimer SA, Sima A.A. Sorbitol, phosphoinositides and sodiumpotassium-ATPasein thepathogenesis of diabeticcomplications. N Engl J Med 1987; 316(10): 599–606.
40. Khaki AA, Khaki A, Nouri M, Ahmadi Ashtiani HR, Rastegar H, Rezazadeh Sh, et al. Evaluation effects of induced diabetic rat. JMP 2009, 1(29): 70-8.
41. Huang SS, Zheng RL. Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro. Cancer Lett 2006; 239(2): 271-80.
42. Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and -cell damage in rat páncreas. Pharmacol Res 2005; 51(2): 117–23.
43. Bardy G, Virsolvy A, Quignard JF, Ravier MA, Bertrand G, Dalle S, et al. "Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells. Br J Pharmacol 2013; 169(5): 1102-13.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mirchenari M, Tavakoli F. The effect of hydro-alcoholic extract of Salvia officinalis L. on the electrolytes and serum proteins in adult diabetic male rat. Feyz 2017; 21 (6) :517-524
URL: http://feyz.kaums.ac.ir/article-1-3239-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 21, Issue 6 (Bimonthly 2017) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.06 seconds with 45 queries by YEKTAWEB 4645