[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 20, Issue 3 (Bimonthly 2016) ::
Feyz 2016, 20(3): 196-204 Back to browse issues page
Effect of hydro-alcholic extract of Pelargonium graveolens L. on serum lipid profile in male rat
Fatemeh Heydari , Naser Mirazi
Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan, I. R. Iran. , mirazi205@gmail.com
Abstract:   (5177 Views)

Background: Hyperlipidemia is considered as the major modifiable risk factor in the process of cardiovascular disorders. Pelargonium graveolens has several medicinal properties. The aim of this study was to investigate the effects of hydro-alcholic extract of Pelargonium graveolens (EPG) on serum lipid profile in male rat.

Materials and Methods: In this experimental study, male Wistar rats (n=35, weight 180-200 gr) were divided in five equal groups: Control (normal diet); Sham1 and 2 [high-fat diet(HFD) and HFDL (HFD + Lovastatin  20 mg/kg)]; Treatment groups 1 and 2 [HFD + EPG (150mg/kg and 300mg/kg), respectively] for 28 days. At the end of experiments, blood samples were collected directly from heart for serum lipid evaluation. All data were expressed as Mean±SE at a statistical significance difference level of P<0.05.

Results: The data of this study showed that when compared to Sham  group the consumption  of EPG in animals   fed by HFD, the serum levels of cholesterol, TG and  LDL were decreased, while HDL was increased significantly (P<0.001).

Conclusion: The use of EPG can play an important role in decreasing serum cholesterol level and other serum lipids compared to Lovastatin. This finding may be attributed to the presence of antioxidants in EPG and their cholesterol synthesis inhibition mechanisms.

Keywords: Pelargonium, Lovastatin, Rat, Cholesterol
Full-Text [PDF 313 kb]   (2031 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/08/8 | Revised: 2017/08/2 | Accepted: 2016/08/8 | Published: 2016/08/8
References
1. Sengupta A, Ghosh M. Modulation of platelet aggregation, haematological and histological parameters by structured lipids on hypercholesterolemic rats. Lipids 2010; 45(5): 393-400.
2. Lee P, Prasad K. Suppression of oxidative stress as a mechanism of reduction of hypercholesterolemic atherosclerosis by cyclooxygenase inhibitor in rat. Int J Angiol 2003; 12(1): 13-23.
3. Javaheri J, Ahmadlou M. The correlation between serum apo lipoprotein A1 and apo lipoprotein B with coronary artery disease and its severity. Arak Med Univ J 2013; 16(75): 8-14.
4. Tringali G, Vairano M, Dello Russo C, Preziosi P, Navarra P. Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. Neurosci Lett 2004; 354(2): 107-10.
5. Kim HJ, Oh GT, Park YB, Lee MK, Seo HJ, Choi MS. Naringin alters the cholesterol biosynthesis and ntioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. Life Sci 2004; 74(13): 1621-34.
6. Bhardwaj PK, Dasgupta DJ, Prashar BS, Kaushal SS. Control of hyperglycaemia and hyperlipidaemia by plant product. J Assoc Physicians India 1994; 42(1): 33-5.‌
7. Zargari A. Iranian Medicinal Plants. 6th ed. Tehran: Tehran University; 1997. p. 243-5.
8. Duchow S, Blaschek W, Classen B. Reproduction of medicinal plant Pleargonium sidoides via somatic embryogenesis. Planta Med 2015; 81(12-13): 1169-74.
9. Bao Y, Gao Y, Koch E, Pan X, Jin Y, Cui X. Evaluation of pharmacodynamic activities of EPs-7630, a special extract from roots of Pleargonium sidoides, in animal models of cough, seretolytic activity and acute bronchitis. Phytomedicine 2015; 22(4): 504-9.
10. Safavi M, Shams-Ardekani M, Foroumadi A. Medicinal plants in the treatment of Helicobacter pylori infections. Pharm Biol 2015; 53(7): 939-60.
11. ‌Farhadi K, Javadifar A, Farthadi. Effects of Brberis vulgaris extract on blood cholesterol and triglyceride in hyperlipidemic patients. J Semnan Univ Med Sci 2008; 9(3): 211-6. [in Persian]
12. Kabiri N, Asgary S. Effect of hydroalcoholic extracts of Amaranthus caudatus on inflammation markers level in hypercholesterolemic Rat. J Gorgan Univ Med Sci 2012; 13: 20-6. [in Persian]
13. Asha GV, Raja Gopal Reddy M, Mahesh M, Vajreswari A, Jeyakumar SM. Male mice are susceptible to high fat diet-induced hyperglycaemia and display increased circulatory retinol binding protein 4 (RBP4) levels and its expression in visceral adipose depots. Arch Physiol Biochem 2016; 122(1): 19-26.
14. ‌Asgary S, Naderi G, Dashti G, Paknahad Z. Effect of Amirkabiria odorastissima on the development and progression of fatty streaks in hypercholesterolemic rabbits. Phytother Res 2004; 18(5): 370-2.
15. ‌Khalili H, Gholami Kh, Dashti S, Ramezani R. Comparison of Gemfibrozil and lipid effects on reduction of serum levels of triglyceride and cholesterol in hyperlipedimic patients. J Kerman Univ Med Sci 2007; 14: 19-24. [in Persian]
16. ‌Shahrani M, Pilehvarian A, Khayri S, Asgahri A, Farokhi A, Parvin N, et al. Effects of Kelussia odorastissima (KOM) extract on blood lipid in Balb/c mice. Shahrekord Univ Med Sci J 2009; 10(4): 50-6. [in Persian]
17. Isah AB, Ibrahim YK, Abdulrahman EM, Ibrahim MA. The hypoglycaemic activity of the aqueous extract of Stachytarpheta angustifolia (Verbanaceae) in normoglycaemic and alloxan-induced diabetic rats. Pak J Biol Sci 2007; 10: 137-41.
18. ‌Gama MP, Pellegrinello S, Alonso SS, Coelho JF, Martins CF, Biagini GL. High doses statins administration causing rhabdomyolysis: case report. Arq Bras Endocrinol Metabol 2005; 49(4): 604-9.
19. Divband K, Komeyli G, Saidi nik F. Effects of Walnut leaves aqueous extract on blood sugar and serum lipids in diabetic rats. J Birjand Univ Med Sci 2008; 17: 11-8. [in Persian]
20. Falah Hosseini H, Fakhrzadeh H, Larijani B, Shikh Samani AH. Review of anti-diabetic medicinal plant used in traditional medicine. J Med Plants 2006; 15: 85-60. [in Persian]
21. Fathiazad F, Garjani A, Motavallian naini A. Study of hypoglycemic activity of the hydroalcholic extract of Juglans regia in normal and diabetic rats. Pharm Sci 2006; 2: 13-7.
22. Mahboobi M, Shahcheraghi F, Feizabadi M. Bactericidal effects of essential oils from clove، lavender and geranium on multi-drug resistant isolates of Pseudomonas aeruginusa .Iran J Biotechnol 2006; 4: 137-40.
23. Shahrani M, Pilevarian A, Kheyri S, Asgari A, Farokhi E, Parvin N, et al. The effects on blood lipids in mice Kelussia odoratissima. J Shahrekord Univ Med Sci 2007; 1: 50-6. [in Persian]
24. Schick PK, Wojenski CM, Walker J. The effects of olive oil, hydrogenated palm oil, and omega-3 fatty acid-enriched diets on megakaryocytes and platelets. Arterioscler Thromb 1993; 13(1): 84-9.
25. Kishor KS, Jain MK, Kathiravan RS, Shishoo CJ. The biology and chemistry of hyperlipidemia. Bioorg Med Chem 2007; 15(14): 674-820.
26. Mahdavi R, Paknahad Z, Asgari S, Naderi GhA, Mahboob S, Rajabi P, et al. Effect of dietary Olive oil/ Cholesterol on serum lipoproteins, lipid peroxidation and atherosclerosis in rabbits. J Res Med Sci 2003; 8(1): 15-9.
27. Acín S, Navarro M, Perona J, Arbonés-Mainar J, Surra J, Guzmán M, et al. Olive oil preparation determines the atherosclerotic protection in apolipoprotein E knockout mice. J Nutr Biochem 2007; 18(6): 418-24.
28. El-Arab AE, Foheid S, El-said M. Effect of yeast and botanical on serum lipid profile and cecum probiotic bacteria using rats fed cholesterol diet. J Food Nutr Sci 2009; 59(2): 169-74.
29. Maurizio A, Ulisse G, Pierfrancesco A. Plasma levels of oxidized-low-density lipoproteins are higher in patients with unstable angina and correlated with angiographic coronary complex plaques. Atherosclerosis 2006; 185(1): 114-20.
30. ‌ Yasuaki D, Hiroyuki T, Koichi S. Association among C-reactive protein, oxidative stress, and traditional risk factors in healthy Japanese subjects. Intern J Cardiol 2007; 115(1): 63-6.
31. Forghany BM, Goharian V, Kasaeian N, Amini M. Examine the effects of vitamin C supplementation on serum lipoproteins in patients with NIDDM. J Med Council Islamic Republic Iran 2001; 19(2): 95-100. [in Persian]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Heydari F, Mirazi N. Effect of hydro-alcholic extract of Pelargonium graveolens L. on serum lipid profile in male rat. Feyz 2016; 20 (3) :196-204
URL: http://feyz.kaums.ac.ir/article-1-3076-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 20, Issue 3 (Bimonthly 2016) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4645