[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 18, Issue 1 (Bimonthly 2014) ::
Feyz 2014, 18(1): 60-67 Back to browse issues page
Relationship between antimicrobial resistance and class I integron in Pseudomonas aeruginosa isolated from clinical specimens in Yazd during 2012-2013
Mohadeseh Zarei-Yazdeli , Gilda Eslami , Hengameh Zandi * , Seyyed Morteza Mousavi , Hasan Kosha , Fatemeh Akhavan , Masoumeh Kiani
Asistant Professor Shahid- Sadoughi University of Medical Sciences , hengameh_zandi@yahoo.com
Abstract:   (4055 Views)

Background: Antimicrobial resistance in Pseudomonas aeruginosa has been increasing in recent years. The aim of this study was to investigate the relationship between antimicrobial resistance and class I integron in P. aeruginosa isolated from clinical specimens in Yazd city.

Materials and Methods: This cross-sectional study was carried out on 144 P. aeruginosa strains from April 2012 to April 2013. All clinical samples were initially identified by the biochemical method and the antibiotic resistance test was performed using the disc diffusion method according to CLSI recommendations. PCR was carried out for the detection of class I integron.

Results: Seventy-nine (54.9%) out of 144 patients were male with mean age of 34.9+22.7 years. Resistance rates to various antibiotics were as follows: gentamicin (63.2%), imipenem (62.5%), amikacin (58.3%), ceftazidime (56.9%), ticarcillin (55.6%), tobramycin (55.6%), piperacillin (54.9%) and ciprofloxacin (48.6%) and 75.3% of the isolates were detected as multi-Drug resistant. PCR results showed that 119 (82.6%) P. aeruginosa isolates carried class I integron.

Conclusion: Class I integrons are commonly found in P. aeruginosa isolated from the clinical samples. Therefore, the transfer of antibiotic resistance genes is often related to these integrons and the contribution of integrons in antibiotic resistance should be evaluated.

Keywords: P. aeruginosa, Antimicrobial resistance, Class I integron
Full-Text [PDF 297 kb]   (1052 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2014/02/6 | Accepted: 2014/02/6 | Published: 2014/02/6
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zarei-Yazdeli M, Eslami G, Zandi H, Mousavi S M, Kosha H, Akhavan F et al . Relationship between antimicrobial resistance and class I integron in Pseudomonas aeruginosa isolated from clinical specimens in Yazd during 2012-2013. Feyz. 2014; 18 (1) :60-67
URL: http://feyz.kaums.ac.ir/article-1-2181-en.html


Volume 18, Issue 1 (Bimonthly 2014) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 3752