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:: Volume 21, Issue 5 (Bimonthly 2017) ::
Feyz 2017, 21(5): 483-489 Back to browse issues page
Seroepidemiology of Toxoplasma gondii infection in immunodeficiency patients in Kashan and Qom during 2014-2015
Malihe Hassanzadeh , Sima Rasti , Hosein Hooshyar , Mansoreh Momen–Heravi , Alireza Soliemani , Seyyed Gholam Abbas Mousavi
Department of Parasitology and Mycology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I. R. Iran. , Rasti_s@yahoo.com
Abstract:   (586 Views)
Background: Toxoplasma gondii is an opportunistic parasitic protozoon, which is a causative agent of serious complications such as encephalitis in immunodeficiency patients. Considering insufficient data on toxoplasmosis in these patients, the present study was conducted to determine the seroepidemiology of T. gondii among immunodeficiency patients.
Materials and Methods: This cross-sectional study was conducted on cancer, ADIS, hemodialysis and renal transplant patients (case group) and healthy persons (control group) in Kashan and Qom cities. Totally, 317 serum samples were collected from the case group and 120 samples from the control group. The ELISA method was used to determine the anti-T. gondii IgG and IgM antibodies.
Results: Totally, 60.3% of the samples from the case and 33.3% from the control groups were positive for anti-T. gondii IgG (P<0.001). In the case group, only 2 persons (0.6%) were positive for anti-T. gondii IgM. The anti-T. gondii IgG detected in immunodeficiency patients was 55.2% in Kashan and 68% in Qom, which were higher than in the control group (P<0.001, P<0.006, respectively). The highest prevalence of T. gondii were seen in 40-59 years old (49.8%) and illiterate (60%) patients. There was a meaningful correlation between toxoplasmosis and blurry vision and dermal rash (P=0.001 and P=0.003, respectively).
Conclusion: The prevalence of T. gondii was higher in different immunodeficiency patients compared to healthy persons. Screening examinations were recommended for the diagnosis and treatment of patients to prevent serious side-effects and health education.
Keywords: Toxoplasma gondii, Immunodeficiency, Seroepidemiology
Full-Text [PDF 234 kb]   (169 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2017/05/27 | Accepted: 2017/09/10 | Published: 2017/11/20
References
1. Jones JL, Dubey JP. Waterborne Toxoplasmosis–Recent developments. Exp Parasitol 2010; 124(1): 10-25.
2. Robert-Gangneux F, Darde ML. Epidemiology of and diagnostic strategies for Ttoxoplasmosis. Clin Microbiol Rev 2012; 25(2): 264–96.
3. Edrissian Gh, Rezaeian M, Ghorbani M, Keshavarz H, Mohebali M. Medical protozoology. 2 ed. TUMS Pub 2015. [in Persian]
4. Xavier GA, Cademartori BG, Cunha Filho NA, Farias NA. Evaluation of seroepidemiological toxoplasmosis in HIV/AIDS patients in the south of Brazil .Rev Inst Med Trop Sao Paulo 2013; 55(1): 25-30.
5. Yazar S, Yaman O, Eser B, Altuntas F, Kurnaz F, Sahin I. Investigation of anti-Toxoplasma gondii antibodies in patients with neoplasia. J Med Microbiol 2004; 53(Pt 12): 1183-6.
6. Ghasemian M, Maraghi Sh, Saki J, Pedram M. Determination of Antibodies (IgG, IgM) against Toxoplasma gondii in Patients with Cancer. Iran J Parasitol 2007; 2(4): 1-6.
7. Mardani A, Keshavarz H, Hossieni gavanlooei S. Seroprevalence of anti toxoplasma (IgG,IgM) in HIV positive individual in Central prison of Qom province. Iran J Infect Dis Tropical Med 1383; 9(27): 19-22. [in Persian]
8. Rostami A, Keshavarz H, Shojaee S, Mohebali M, Meamar AR. Frequency of Toxoplasma gondii in HIV Positive Patients from West of Iran by ELISA and PCR. Iran J Parasitol 2014; 9(4): 474-81.
9. Saki J, Khademvatan S, Soltani S, Shahbazian H. Detection of toxoplasmosis in patients with end-stage renal disease by enzyme-linked immunosorbent assayand polymerase chain reaction methods. Parasitol Res 2013; 112(1): 163–8.
10. Soltani S, Khademvatan S, Saki J, Shahbazian H. Detection of Toxoplasmosis in Renal Transplant Recipients by ELISA and PCR Methods in Ahvaz, South-West of Iran. Jundishapur J Microbiol 2013; 6(9): 1-5.e7642.
11. Pereira-Chioccola VL, Ernesto Vidal J, Su C. Toxoplasma gondii infection and cerebral toxoplasmosis in HIV-infected patients. Future Microbiol 2009; 4(10): 1363-79.
12. Yan J, Huang B, Liu G, Wu B, Huang S, Zheng H, et al. Meta-analysis of prevention and treatment of toxoplasmic encephalitis in HIV-infected patients. Acta Tropica 2013; 127(3): 236-44.
13. Collier L, Ballows A, Sussman M. Topley and Wilson's Microbiology and Microbial Infections: Vol 5: Parasitology. 9th ed. Arnold (U.S.A); 1999.
14. Bayani M, Mostafazadeh A, Oliaee F, Kalantari N. The Prevalence of Toxoplasma gondii in Hemodialysis Patients. Iran Red Crescent Med J 2013; 15(10): e5225.
15. Maraghi SH, Yadyad MJ, Sheikhi M, Shamakhteh F, Latifi SM. Study the Anti-Toxoplasma Antibodies (IgG and IgM) in Hemodialysis Pa‌tients of Abadan and Khoramshahr Cities Southwest Iran in 2011 using ELISA. Jundishapur J Microbiol 2013; 6(7): e7113.
16. Fallahi S, Kazemi B, Bandehpour M, Lasjerdi Z, Taghipour N, Zebardast N, et al. Comparison of the RE and B1 gene for detection of Toxoplasma gondii infection in children with cancer. Parasitol Int 2014; 63(1): 37-41.
17. Wang L, He LY, Meng DD, Chen ZW, Wen H, Fang GS, et al. Seroprevalence and genetic characterization of Toxoplasma gondii in cancer patients in Anhui Province, Eastern China. Para Vec 2015; 8(1): 162.1-7.
18. Mohraz M, Mehrkhani F, Jam S, Seyed Alinaghi SA, Sabzvari D, Fattahi F, et al. Seroprevalence of toxoplasmosis in HIV (+)/AIDS patients in Iran. Acta Med Iran 2011; 49(4): 213-8.
19. Rahimi MT, Mahdavi SA, Javadian B, Rezaei R, Moosazadeh M, Khademlou M, et al. High Seroprevalence of Toxoplasma gondii Antibody in HIV/AIDS Individuals from North of Iran. Iran J Parasitol 2015; 10(4): 584-9.
20. Domingos A, Ito LS, Coelho E, Lúcio JM, Matida LH, Ramos AN Jr. Seroprevalence of Toxoplasma gondii IgG antibody in HIV/AIDS-infected individuals.in Maputo, Mozambique. Rev Saude Publica 2013; 47(5): 890-6.
21. Yazar S, Demirtaş F, Yalçin S, Yaman O, Tokgöz B, Utaş C, et al. Anti-Toxoplasma gondii antibodies in haemodialysis patients with chronic renal failure. Yonsei Med J 2003; 44(2): 288-92.
22. Ocak S, Duran N, Eskiocak AF, Aytac H. Anti-Toxoplasma gondii antibodies in hemodialysis patients receiving long-term hemodialysis therapy in Turkey. Saudi Med J 2005; 26(9): 1378-82.
23. Izadi M, Jonaidi Jafari N, Mahmoodzadeh Poornaki A, Sadraei J, Rezavand B, Mirzaei HR, et al. Detection of Toxoplasma gondii from Clinical Specimens of Patients Receiving Renal Transplant Using ELISA and PCR. Nephrourol Mon 2013: 5(5): 983-7.
24. Basavaraju A. Toxoplasmosis in HIV infection: An overview. Trop Parasitol 2016; 6(2): 129–35.
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Hassanzadeh M, Rasti S, Hooshyar H, Momen–Heravi M, Soliemani A, Mousavi S G A. Seroepidemiology of Toxoplasma gondii infection in immunodeficiency patients in Kashan and Qom during 2014-2015. Feyz. 2017; 21 (5) :483-489
URL: http://feyz.kaums.ac.ir/article-1-3354-en.html


Volume 21, Issue 5 (Bimonthly 2017) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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