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:: Volume 29, Issue 7 (Special Issue 2025) ::
Feyz Med Sci J 2025, 29(7): 673-678 Back to browse issues page
Improving the management of cystic echinococcosis through enhancing the accuracy of serological diagnosis: A policy brief
Mohsen Arbabi * , Amin Moradi Hassan Abad , Abolfazl Masoumi Koushk Mehdi , Yasaman Zare
Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran & Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran , arbabi4.mohsen@yahoo.com
Abstract:   (230 Views)
Cystic Echinococcosis (CE) is a parasitic zoonosis of significant medical and economic importance in Iran, affecting both humans and livestock. The disease causes the loss of approximately 1 million disability-adjusted life years (DALYs). Ultrasonography remains the primary method for diagnosing and staging hepatic hydatid cysts. However, serological assays can provide valuable complementary information, particularly for confirming early infections, detecting inactive cysts, and identifying small or encapsulated lesions that may be difficult to characterize through imaging alone. Diagnostic accuracy is hindered by several persistent challenges, including the widespread use of crude antigens, stage-dependent variability in test sensitivity, the lack of standardized stage-specific diagnostic algorithms, and limited availability of rapid, point-of-care tests. This review aims to outline evidence-based strategies to enhance serological diagnostic capacity for CE. It emphasizes the development of high-specificity recombinant antigens, the establishment of standardized testing protocols, the creation of cyst-stage-adapted diagnostic algorithms, and the integration of rapid diagnostic tools into the primary health-care system.
Keywords: Hydatid cyst, Diagnostic accuracy, Serology, Ultrasound, Policy Brief
Full-Text [PDF 372 kb]   (73 Downloads)    
Type of Study: Policy Brief | Subject: medicine, paraclinic
Received: 2025/11/23 | Revised: 2026/04/8 | Accepted: 2025/12/29 | Published: 2026/03/15
References
1. Kern P, Menezes da Silva A, Akhan O, Müllhaupt B, Vizcaychipi KA, Budke C, et al. The echinococcoses: diagnosis, clinical management and burden of disease. Adv Parasitol. 2017;96:259-369. doi:10.1016/bs.apar.2016.09.006.
2. Nakao M, Yanagida T, Okamoto M, Knapp J, Nkouawa A, Sako Y, et al. State-of-the-art Echinococcus and Taenia: phylogenetic taxonomy of human-pathogenic tapeworms and its application to molecular diagnosis. Infect Genet Evol. 2010; 10: 444-52. doi:10.1016/j.meegid.2010.01.011 PMid:20132907
3. Talafuhan W, Tuoheti K, Lixia Y, Shuang Q, Yeerjiang M, Aizezi G, et al. Trends in incidence, mortality, and DALYs of cystic echinococcosis in Central Asia from 1992 to 2021: an age-period-cohort analysis. Front Public Health. 2025; 12: 1504481. doi:10.3389/fpubh.2024.1504481.PMid:39959907 PMCid:PMC11826808
4. Deplazes P, Rinaldi L, Alvarez Rojas CA, Torgerson PR, Harandi MF, Romig T, et al. Global distribution of alveolar and cystic echinococcosis. Adv Parasitol. 2017; 95:315-493. doi:10.1016/bs.apar.2016.11.001 PMCid:PMC5418818
5. AgudeloHiguita NI, Brunetti E, Cindy McCloskey C. Cystic Echinococcosis. J Clin Microbiol. 2016; 54:518 -523. doi:10.1128/JCM.02420-15. PMid:26677245 PMCid:PMC4767951
6. World Health Organization, WHO guidelines for the treatment of patients with cystic echinococcosis, 2025.
7. Goodfellow SM, Karnaze A, Kim H, Zhou S, Posch LC, Costales C. Diagnosis of cystic echinococcosis within a pediatric hospital setting. ASM Case Rep. 2025;14:e00040-25. doi.10.1128/asmcr.00040-25.PMid:41245669 PMCid:PMC12466015
8. Meng Y, Ren Q, Xiao J, Sun H, Huang Y, Yaqing L, et al. Progress of research on the diagnosis and treatment of bone cystic echinococcosis. Progress of research on the diagnosis and treatment of bone cystic echinococcosis. Front Microbiol. 2023; 14:1-12. doi:10.3389/fmicb.2023.1273870. PMid:37920269 PMCid:PMC10618348
9. Sayek I, Onat D. Diagnosis and treatment of uncomplicated hydatid cyst of the liver. World J Surg. 2001; 25(1):21-7. doi: 10.1007/s002680020004.
10. Manzano-Román R, Sánchez-Ovejero C, Hernández-González A, Casulli A, Siles-Lucas M. Serological diagnosis and follow-up of human cystic echinococcosis: a new hope for the future? Biomed Res Int. 2015;428205. doi:10.1155/2015/428205 PMid:26504805 PMCid:PMC4609352
11. Erganis S, Sarzhanov F, Doğruman Al F, Cağlar K. Comparison of Methods in the Serologic Diagnosis of Cystic Echinococcosis. Acta Parasitol. 2024; 69(2):1122-1131.doi: 10.1007/s11686-024-00840-z. PMid:38551763 PMCid:PMC11182860
12. Darabi E, Motevaseli E, Khorramizadeh MR, Mohebali M, Rokni MB, Zahabiun F, et al. Design and construction of a fusion peptide containing B1, B2, B4, and EPC1 epitopes for diagnosis of human cystic echinococcosis. Iran J Public Health 2019; 48:1671-80.doi:10.18502/ijph.v48i9.3027
13. Fathi S, Jalousian F, Hosseini SH, Najafi A, Darabi E, Koohsar F. Design and construction of a new recombinant fusion protein [2b2t+EPC1) and its assessment for serodiagnosis of cystic echinococcosis. APMIS. 2018;126:428-39. doi:10.1111/apm.12838. PMid:29696723
14. Darabi E, Motevaseli E, Mohebali M, Rokni MB, Khorramizadeh MR, Zahabiun F, et al. Evaluation of a novel Echinococcus granulosus recombinant fusion B-EpC1 antigen for the diagnosis of human cystic echinococcosis using indirect ELISA in comparison with a commercial diagnostic ELISA kit. Exp Parasitol. 2022; 240:108-339. doi:10.1016/j.exppara.2022.108339. PMid:35863520
15. MasoumiKoushk Mehdi A, Moteday H, FasihiHarandi M, Akbari H, Moradi Hasan-Abad A, Arbabi M. Design and evaluation of a novel direct hemagglutination test based on a recombinant protein for diagnosis of cystic echinococcosis. Parasit Vectors. 2025; 18:267. doi: 10.1186/s13071-025-06900-1.
16. Tamarozzi F. Ultrasound diagnosis of cystic echinococcosis: updates and implications for clinical management. J Hel 2024; 98:e34. doi: 10.1017/S0022149X2400021X. PMid:38628145
17. Manzano-RománR, Sánchez-Ovejero C, Hernández-González A, Casulli A, Siles-Lucas M. Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? BioMed Res Int. 2015; 2015: 428205. doi.10.1155/2015/428205. PMid:26504805 PMCid:PMC4609352
18. Tamarozzi F, Silva R, Fittipaldo VA, Buonfrate D, Gottstein B, Siles-Lucas M. Serology for the diagnosis of human hepatic cystic echinococcosis and its relation with cyst staging: A systematic review of the literature with meta-analysis. Meta-Analysis PLoSNegl Trop Dis. 2021; 28: 15(5): e0009370. doi:10.1371/journal.pntd.0009370.PMid:33909640 PMCid:PMC8081258
19. Maleki F, Akhlaghi L, Tabatabaie F. Evaluation of Hydatid Cyst Antigen for Serological Diagnosis. Med J Islam Repub Iran. 2023; 14:37:87. doi: 10.47176/mjiri.37.87.
20. Siles-Lucas M, Uchiumi L, Tamarozzi F. No cyst, no echinococcosis: a scoping review update on the diagnosis of cystic echinococcosis after the issue of the WHO-IWGE Expert Consensus and current perspectives. Curr Opin Infect Dis. 2023; 18; 36(5): 333-40. doi:10.1097/QCO.0000000000000941.PMid:37466103 PMCid:PMC10487401
21. Tamarozzi F, Covini I, Mariconti M, Narra R, Tinelli C, De Silvestri A, et al.Comparison of the Diagnostic Accuracy of Three Rapid Tests for the Serodiagnosis of Hepatic Cystic Echinococcosis in Humans. PLOS Neglected Tropical Dis. 2016; 1-13. doi:10.1371/journal.pntd.0004444. PMid:26871432 PMCid:PMC4752287
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Arbabi M, Moradi Hassan Abad A, Masoumi Koushk Mehdi A, Zare Y. Improving the management of cystic echinococcosis through enhancing the accuracy of serological diagnosis: A policy brief. Feyz Med Sci J 2025; 29 (7) :673-678
URL: http://feyz.kaums.ac.ir/article-1-5444-en.html


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Volume 29, Issue 7 (Special Issue 2025) Back to browse issues page
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