fa اثر هشت هفته تمرین هوازی به‌همراه مصرف عصاره بابونه بر سطوح پروتئین BDNF هایپوکمپ موش‌های دارای دیابت نوع 1 عمومى General پژوهشي Research <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">زمینه و هدف:</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> دیابت موجب کاهش عملکرد شناختی می‌شود، در مقابل، عصاره بابونه و تمرین استقامتی ممکن است بر بهبود عملکرد شناختی مؤثر باشند. بنابراین، هدف مطالعه حاضر بررسی اثر عصاره بابونه در خلال تمرین استقامتی بر سطوح گلوکز خون و پروتئین </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">BDNF</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> هایپوکمپ موش&shy;های دارای دیابت نوع یک بود.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">روش&shy;ها:</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> در این مطالعه تجربی 30 سر موش صحرایی نر بالغ به&shy;طور تصادفی به پنج گروه کنترل (</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">C</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">)، دیابت (</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">D</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">)، دیابت-تمرین استقامتی (</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">DT</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">)، دیابت-عصاره بابونه (</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">DS</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">) و دیابت-عصاره بابونه-تمرین استقامتی (</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">DTS</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">) تقسیم شدند. تمرین استقامتی پنج جلسه در هفته به&shy;مدت هشت هفته انجام شد. عصاره بابونه با دوز ۲۵۰ میلی‌گرم/کیلوگرم به‌صورت خوراکی (گاواژ) روزانه تجویز شد. سطوح گلوکز خون و پروتئین </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">BDNF</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> هایپوکمپ به‌روش الایزا اندازه&shy;گیری شد. برای تحلیل داده&shy;ها از آنالیز واریانس یک&shy;طرفه در سطح معناداری 05/0></span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> استفاده شد.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">یافته‌ها:</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> گلوکز خون در گروه‌های دیابتی بالاتر از گروه </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">C</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> بود (001/0=</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">). تمرین و عصاره بابونه هر دو گلوکز را کاهش دادند، اما اثر ترکیبی آن‌ها معنادارتر بود (001/0=</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">). همچنین، دیابت سطوح پروتئین </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">BDNF</span></span><span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> را به&shy;طور معناداری کاهش داد (05/0></span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">). با این حال، سطوح پروتئین </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">BDNF</span></span><span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> در گروه&shy;های </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">DT</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">DS</span></span><span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> به‌طور یکسان و غیرمعناداری افزایش یافت (36/0</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">p=</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">). اما، سطوح پروتئین </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">BDNF</span></span><span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> در گروه </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">DTS</span></span><span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> به‌طور معناداری افزایش یافت (006/0=</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">).</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">نتیجه&shy;گیری:</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> تعامل عصاره بابونه و تمرین استقامتی اثر مثبتی بر سطوح گلوکز خون و پروتئین </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">BDNF</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> هایپوکمپ در دیابت نوع یک دارد. بنابراین، به‌نظر می‌رسد مصرف عصاره بابونه در خلال تمرین استقامتی راهکاری بسیار مؤثر برای بهبود عملکرد شناختی در دیابت نوع یک است.</span></span></span></span></span></span></span> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background and Aim</span></span></b><b><span lang="EN" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">:</span></span></b> <span lang="EN" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Diabetes causes a decrease in cognitive function, in contrast, chamomile extract and endurance training may be effective in improving cognitive function. Therefore, the aim of the present study was to investigate the effect of chamomile extract during endurance training on blood glucose and hippocampal BDNF protein levels in type 1 diabetic rats.</span></span><span style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Methods:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> In this experimental study, 30 adult male rats were randomly divided into five groups: control (C), diabetes (D), diabetes-endurance training (DT), diabetes-chamomile extract (DS), and diabetes-chamomile extract- endurance training (DTS). Endurance training performed five sessions/w for eight weeks. Chamomile extract was administered orally by gavage at a dose of 250 mg/kg daily. Blood glucose and hippocampal BDNF protein levels were measured using ELISA. To analyze the data, one-way ANOVA was used at the significance level of p< .05.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Blood glucose levels were higher in all diabetic groups compared to the C group (p=0.001). Both endurance training and chamomile extract significantly reduced blood glucose, but their combined effect was more significant (p=0.001). Also, diabetes significantly decreased BDNF protein levels (p<0.05). However, BDNF protein levels increased equally and non-significantly in DT and DS groups (p=0.36). But, BDNF protein levels increased significantly in DTS group (p=0.006).</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> The interaction of chamomile extract and endurance training has a positive effect on blood glucose and hippocampal BDNF protein levels in type 1 diabetes. Therefore, it seems that consuming chamomile extract during endurance training is a very effective strategy to improve cognitive function in type 1 diabetes.</span></span></span></span></span> تمرین استقامتی, دیابت نوع یک, عصاره بابونه, پروتئین BDNF Keywords: Endurance training, Type 1 diabetes, Chamomile extract, BDNF protein 0 0 http://feyz.kaums.ac.ir/browse.php?a_code=A-10-3224-15&slc_lang=fa&sid=1 Mohammad asadi Nik محمد اسدی نیک vahidvalipourdehnou@gmail.com 2900319475328460054175 2900319475328460054175 No Lorestan University دانشگاه لرستان Vahid Valipour Dehnou وحید ولی‌پور ده‌نو valipour.v@lu.ac.ir 2900319475328460054176 2900319475328460054176 Yes Lorestan University دانشگاه لرستان Ali Nazarian علی نظریان valipour114@yahoo.com 2900319475328460054177 2900319475328460054177 No Lorestan University دانشگاه لرستان