fa مقایسه متغیرهای اکوکاردیوگرافیکی قلب، شاخص‌های HRV در بزرگسالان مرد چاق سالم و چاق با سندرم متابولیک عمومى General پژوهشي Research <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="AR-SA" lotus="" style="font-family:">سابقه و هدف:</span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">چاقی و سندرم متابولیک از عوامل اصلی خطر بیماری‌های قلبی-عروقی هستند. این مطالعه با هدف مقایسه شاخص‌های تغییرپذیری ضربان قلب</span></span></span></b><b> </b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">(</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">HRV</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">)، متغیرهای اکوکاردیوگرافیک ساختاری و عملکردی قلب و شاخص مقاومت به انسولین مبتنی بر سندرم متابولیک (</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">METS-IR</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">)</span></span></span></b><b> </b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">در مردان چاق سالم و چاق دارای سندرم متابولیک انجام شد.</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="AR-SA" lotus="" style="font-family:">مواد و روش‌ها:</span></b><b>&nbsp;</b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">در این مطالعه مقطعی مقایسه‌ای، </span></span></span></b><b><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">۴۴</span></span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:"> مرد چاق بدون سابقه بیماری قلبی، بر اساس معیار</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"> NCEP ATP III </span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">در دو گروه چاق سالم (</span></span></span></b><b><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">۲۲</span></span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:"> نفر) و چاق با سندرم متابولیک (</span></span></span></b><b><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">۲۲</span></span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:"> نفر) قرار گرفتند. متغیرهای آنتروپومتریک، متابولیک</span></span></span></b><b> </b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">(</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">FBG</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">TG</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">HDL</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">METS-IR</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">)، قلبی-عروقی (فشار خون، ضربان قلب)، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">HRV </span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">(</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">SDNN</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">RMSSD</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">LF/HF</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">) </span></span></span></b><b>&nbsp;</b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">در سه وضعیت استراحت، حین ورزش و ریکاوری</span></span></span></b><b>&nbsp;</b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">(با هولتر</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"> ECG</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">)</span></span></span></b><b> </b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">و متغیرهای اکوکاردیوگرافیک</span></span></span></b><b> </b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">(</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">LVM</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">LVEDV</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">EF</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">E/A</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">)</span></span></span></b><b> </b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">اندازه‌گیری شدند. تحلیل داده‌ها با آزمون</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"> t-test </span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">مستقل انجام گرفت.</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="AR-SA" lotus="" style="font-family:">نتایج: </span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">گروه چاق با سندرم متابولیک مقادیر بالاتری از</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"> FBG</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">TG</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">METS-IR</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، فشار خون و ضربان قلب</span></span></span></b><b> </b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">(<i>P</i>-value <0.05) </span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">و مقادیر پایین‌تری از</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"> SDNN</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">RMSSD</span></span></b><b><span style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:"> به‌جز</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"> RMSSD_rest </span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">با</span></span></span></b><b> </b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">(</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">P=0.058</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">)</span></span></span></b><b>&nbsp;</b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">و مقادیر بالاتری از نسبت</span></span></span></b><b> </b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">LF/HF&nbsp;</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">در استراحت، ورزش و ریکاوری (</span></span></span></b><b><i><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">P</span></span></i></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">-value <0.05</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">) نشان داد. همچنین تفاوت معنی‌داری در</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"> LVM</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">LVEDV</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">، ضخامت دیواره بطن، </span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">EF </span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">و</span></span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"> E/A </span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">بین دو گروه مشاهده شد</span></span></span></b><b> </b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">(</span></span></span></b><b><i><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">P</span></span></i></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%">-value <0.05</span></span></b><b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">).</span></span></span></b><b> </b><b><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span style="font-family:"B Lotus""></span></span></span></b></span></span></span></span></span><br> <b><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">نتیجه‌گیری:</span></span></span>&nbsp;<span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">سندرم متابولیک در افراد چاق با اختلال بیشتر در تعادل اتونومیک قلب، ساختار و عملکرد قلب همراه است.</span></span></span></b> <span style="font-size:11pt"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Background and Objective</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">:&nbsp;Obesity and metabolic syndrome are major risk factors for cardiovascular diseases. This study compared heart rate variability (HRV) indices, structural and functional echocardiographic variables, and the metabolic syndrome‑based insulin resistance index (METS-IR) in healthy obese men and obese men with metabolic syndrome.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Materials and Methods</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">:&nbsp;In this comparative cross-sectional study, 44 obese men with no history of cardiac diseases were divided into two groups: healthy obese (n=22) and obese with metabolic syndrome (n=22) based on NCEP ATP III criteria. Anthropometric, metabolic (FBG, TG, HDL, METS-IR), cardiovascular (blood pressure, heart rate), HRV (SDNN, RMSSD, LF/HF)&nbsp;at rest, during exercise, and recovery&nbsp;(by Holter ECG), and echocardiographic (LVM, LVEDV, EF, E/A) variables were measured. Data were analyzed using independent t-test.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Results:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">&nbsp;The obese group with metabolic syndrome showed higher FBG, TG, METS-IR, blood pressure, and heart rate (<i>P</i>-value <0.05) and lower SDNN, RMSSD (except RMSSD_rest with P=0.058),&nbsp;and higher LF/HF ratio&nbsp;at rest, during exercise, and recovery (<i>P</i>-value <0.05). Significant differences were also found in LVM, LVEDV, ventricular wall thickness, EF, and E/A (<i>P</i>-value <0.05).</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">&nbsp;Metabolic syndrome in obese individuals is associated with greater impairment in cardiac autonomic balance, cardiac structure, and function.</span></span></span></span></span></span> چاقی, سندرم متابولیک, تغییرپذیری ضربان قلب, اکوکاردیوگرافی, شاخص مقاومت به انسولین (METS-IR), مردان Obesity, Metabolic Syndrome, Heart Rate Variability, Echocardiography, Insulin Resistance Index (METS-IR), Men 0 0 http://feyz.kaums.ac.ir/browse.php?a_code=A-10-5135-1&slc_lang=fa&sid=1 salman lofi سلمان لطفی lotfisalman348@gmail.com 2900319475328460053729 2900319475328460053729 Yes Bu-Ali Sina University دانشگاه بوعلی سینا farzad nazem فرزاد ناظم f.nazem@basu.ir 2900319475328460053730 2900319475328460053730 No Bu-Ali Sina University دانشگاه بوعلی سینا Seyed Kianoosh hosseini سید کیانوش حسینی k.hoseini@gmail.com 2900319475328460053731 2900319475328460053731 No Bu-Ali Sina University دانشگاه بوعلی سینا